Journal of Mitochondria Plastids and Endosymbiosis,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Jan. 31, 2024
Redox
medicine
improvement
could
come
from
integrating
insights
both
the
mitochondria
and
redox
fields.
One-step
further
is
finding
new
clues
with
a
comprehensive
discussion
of
two
fields,
their
relationship,
including
through
reactive
species
interactome
(RSI).
Here,
review
provides
platform
for
future
studies
focusing
on
RSI.
Mitochondria
are
discussed
at
length
focus
mitochondrial
permeability
transition
pore,
regulation
cell
death
types,
protein
quality
control
system,
calcium
homoeostasis,
ionome,
metabolome,
carriers,
organelle
interaction.
Then,
RSI
its
relationship
mitochondria.
Finally,
mitochondria-RSI
axis
proposed
as
brand-new
perspective,
involvement
circadian
clock
bacterial
microbiota,
first
stone
concept
MitoRedox
Medicine.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 9, 2025
Copper,
an
essential
trace
element
and
biochemical
cofactor
in
humans
plays
a
critical
role
maintaining
health.
Recent
studies
have
identified
significant
association
between
copper
levels
the
progression
metastasis
of
cancer.
Copper
is
primarily
absorbed
intestinal
tract,
often
leading
to
imbalance
ions
body.
Colorectal
cancer
(CRC),
most
common
originating
intestines,
thrives
environment
with
elevated
concentrations.
Current
research
focused
on
uncovering
relationship
CRC
which
has
introduced
new
concepts
such
as
cuproplasia
cuproptosis,
significantly
deepening
our
understanding
copper's
influence
cell
proliferation
death.
Cuproplasia
kind
mediated
by
co-regulatory
activities
enzymes
non-enzymatic
factors,
while
cuproptosis
refers
death
induced
excessive
copper,
results
abnormal
oligomerization
lipacylated
proteins
reduction
iron-sulfur
cluster
proteins.
Exploring
opens
avenues
for
treating
CRC.
This
review
aims
summarize
promoting
colorectal
cancer,
dual
effects
tumor
microenvironment
(TME),
strategies
leveraging
this
unique
induce
Understanding
holds
promise
establishing
theoretical
foundation
innovative
therapeutic
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Abstract
Heavy
metals
influence
the
development
of
several
health
conditions,
including
inflammation
and
cancer.
This
study
investigates
relationship
between
heavy
metal
concentrations
in
plasma
urine,
presence
benign
prostatic
hyperplasia
(BPH),
precancerous
lesions
(PL),
prostate
cancer
(PC).
The
age,
total
PSA
levels,
hemoglobin
concentrations,
monocyte-to-lymphocyte
ratio
(MLR)
is
also
analyzed
across
three
groups:
BPH,
PL,
PC.
Our
findings
reveal
significant
differences
vanadium
antimony
plasma,
suggesting
a
potential
role
disease
pathophysiology.
Notably,
lower
are
associated
with
an
increased
risk
PC,
while
significantly
higher
PL
group.
Regression
analysis
further
supports
association
highlighting
copper
as
biomarkers
or
therapeutic
targets
for
health.
explores
impact
lead
exposure
on
risk,
revealing
urine
concentration
These
underscore
complex
interaction
emphasizing
need
research
to
elucidate
underlying
mechanisms
explore
interventions.
Roughly
1.71
billion
people
worldwide
suffer
from
large
bone
abnormalities,
which
are
the
primary
cause
of
disability.
Traditional
grafting
procedures
have
several
drawbacks
that
impair
their
therapeutic
efficacy
and
restrict
use
in
clinical
settings.
A
great
deal
work
has
been
done
to
create
fresh,
more
potent
strategies.
Under
these
circumstances,
a
crucial
technique
for
regeneration
major
lesions
emerged:
tissue
engineering
(BTE).
BTE
involves
biomaterials
can
imitate
natural
design
bone.
To
yet,
no
biological
material
able
fully
meet
parameters
perfect
implantable
material,
even
though
varieties
created
investigated
regeneration.
Against
this
backdrop,
researchers
focused
interest
over
past
few
years
on
subject
nanotechnology
nanostructures
regenerative
medicine.
The
ability
nanoengineered
particles
overcome
current
constraints
strategies─such
as
decreased
cell
proliferation
differentiation,
insufficient
mechanical
strength
materials,
production
extrinsic
factors
required
effective
osteogenesis
revolutionized
field
engineering.
effects
nanoparticles
characteristics
application
materials
main
topics
our
review,
summarizes
most
recent
vitro
vivo
research
context
BTE.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 26, 2025
Oral
squamous
cell
carcinoma
(OSCC)
represents
a
significant
global
health
challenge,
characterized
by
aggressive
progression
and
poor
therapeutic
response
despite
advances
in
treatment
modalities.
This
review
provides
comprehensive
analysis
of
diverse
death
mechanisms
OSCC,
encompassing
traditional
pathways
(apoptosis,
autophagy,
necrosis),
newly
(ferroptosis,
pyroptosis,
necroptosis),
emerging
(cuproptosis,
anoikis,
parthanatos,
entosis).
By
examining
the
molecular
basis
these
pathways,
particularly
crucial
roles
p53
signaling
miRNA
regulation,
we
highlight
how
their
dysregulation
contributes
to
resistance
tumor
progression.
The
synthesizes
recent
evidence
demonstrating
complex
interplay
between
ten
distinct
impact
on
microenvironment
immune
response.
We
evaluate
innovative
approaches
that
target
including
novel
small
molecules,
combination
strategies,
immunomodulatory
treatments
exploit
specific
enhance
efficacy.
Special
attention
is
given
personalized
medicine
strategies
consider
individual
characteristics
pathway
profiles.
integrating
current
challenges
with
future
research
directions,
this
framework
for
developing
more
effective
can
leverage
multiple
overcome
therapy
improve
outcomes
oral
cancer
patients.
