Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(10), P. 1827 - 1839
Published: May 3, 2024
Abstract
Acute
kidney
injury
(AKI)
is
a
life‐threatening
disease
primarily
caused
by
renal
ischemia‐reperfusion
(I/R)
injury,
which
can
result
in
failure.
Currently,
growth
factor
therapy
considered
promising
and
effective
approach
for
AKI
treatment.
Basic
fibroblast
(bFGF),
an
angiogenic
with
potent
activity,
efficiently
stimulates
angiogenesis
facilitates
regeneration
of
tissue.
However,
the
unrestricted
diffusion
bFGF
restricts
its
clinical
application
Therefore,
developing
novel
sustained
released
system
could
enhance
potential
treating
AKI.
In
this
study,
we
genetically
engineered
multifunctional
recombinant
protein
fusing
specific
peptide
(EBP).
EBP‐bFGF
effectively
binds
to
extracellular
matrix
injured
kidney,
enabling
slow
release
Furthermore,
following
orthotopic
injection
into
I/R
rats'
ischemic
kidneys,
exhibited
stable
retention
within
Additionally,
suppressed
apoptosis
cells,
reduced
fibrosis,
facilitated
recovery
function.
These
findings
suggest
that
delivery
represents
strategy
Cancer Control,
Journal Year:
2024,
Volume and Issue:
31
Published: Jan. 1, 2024
Objective
To
evaluate
the
effectiveness
of
oral
probiotic
supplements
in
patients
undergoing
immune
checkpoint
inhibitors
(ICIs)
for
treatment
advanced
lung
cancer.
Methods
This
prospective
real-world
study
enrolled
with
cancer
who
were
receiving
ICIs
as
part
their
treatment.
The
divided
into
2
groups:
Group
OPS
received
along
ICIs,
while
C
did
not.
primary
endpoint
was
progression-free
survival
(PFS).
secondary
outcome
measure
objective
response
rate
(ORR).
Results
A
total
253
included
study,
71
and
182
control
group
(Group
C).
No
significant
differences
observed
median
PFS
between
groups
all
patients.
However,
small
cell
(SCLC)
patients,
significantly
better
compared
to
(11.1
months
vs
7.0
months,
P
=
.049).
non-small
(NSCLC)
cohort
groups,
but
a
trend
towards
noticed
(16.5
12.3
.56).
ORR
entire
58.0%.
Conclusion
Oral
probiotics
combination
regimen
may
improve
SCLC.
above
points
should
be
proved
by
further
study.
