Exploration of Targeted Anti-tumor Therapy,
Journal Year:
2024,
Volume and Issue:
5(6), P. 1223 - 1246
Published: Sept. 29, 2024
Oral
squamous
cell
carcinoma
(OSCC)
is
a
highly
malignant
and
invasive
tumor
with
significant
mortality
morbidity.
Current
treatment
modalities
such
as
surgery,
radiotherapy,
chemotherapy
encounter
limitations,
poor
targeting,
systemic
toxicity,
drug
resistance.
There
an
urgent
need
for
novel
therapeutic
strategies
that
offer
targeted
delivery,
enhanced
efficacy,
reduced
side
effects.
The
advent
of
lipid-based
nanoparticles
(LNPs)
offers
promising
tool
OSCC
therapy,
potentially
overcoming
the
limitations
current
approaches.
LNPs
are
composed
biodegradable
biocompatible
lipids,
which
minimize
risk
toxicity
adverse
can
encapsulate
hydrophobic
drugs,
improving
their
solubility
stability
in
biological
environment,
thereby
enhancing
bioavailability.
demonstrate
significantly
higher
ability
to
lipophilic
drugs
than
other
nanoparticle
types.
excellent
storage
stability,
minimal
leakage,
controlled
release,
making
them
effective
nanoplatforms
delivery
chemotherapeutic
agents.
Additionally,
be
modified
by
complexing
specific
target
ligands
on
surface.
This
surface
modification
allows
active
targeting
tumors
addition
passive
mechanism.
Furthermore,
PEGylation
improves
hydrophilicity
enhances
half-life
reducing
clearance
reticuloendothelial
system.
review
aims
discuss
approaches
well
recent
advancements
better
management
OSCC.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
670, P. 125186 - 125186
Published: Jan. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
RNA
therapeutics,
such
as
mRNA,
siRNA,
and
CRISPR–Cas9,
present
exciting
avenues
for
treating
diverse
diseases.
However,
their
potential
is
commonly
hindered
by
vulnerability
to
degradation
poor
cellular
uptake,
requiring
effective
delivery
systems.
Lipid
nanoparticles
(LNPs)
have
emerged
a
leading
choice
in
vivo
delivery,
offering
protection
against
degradation,
enhanced
facilitation
of
endosomal
escape.
LNPs
encounter
numerous
challenges
targeted
vivo,
demanding
advanced
particle
engineering,
surface
functionalization
with
targeting
ligands,
profound
comprehension
the
biological
milieu
which
they
function.
This
review
explores
structural
physicochemical
characteristics
LNPs,
in-vivo
fate,
customization
therapeutics.
We
highlight
quality-by-design
(QbD)
approach
beyond
liver,
focusing
on
biodistribution,
immunogenicity,
toxicity.
In
addition,
we
explored
current
strategies
associated
ensuring
repeated-dose
efficacy,
safety,
tissue-specific
gene
delivery.
Furthermore,
provide
insights
into
clinical
applications
various
classes
diseases
finally
prospects
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10388 - 10388
Published: Sept. 26, 2024
Bladder
cancer
(BC)
is
one
of
the
most
common
malignant
neoplasms
genitourinary
system.
Traditional
BC
therapies
include
chemotherapy,
targeted
therapy,
and
immunotherapy.
However,
limitations
such
as
lack
specificity,
cytotoxicity,
multidrug
resistance
pose
serious
challenges
to
benefits
therapies.
Consequently,
current
studies
focus
on
search
for
new
therapeutic
solutions.
In
recent
years,
there
has
been
a
growing
interest
in
using
nanotechnology
treatment
both
non-invasive
(NMIBC)
invasive
bladder
(MIBC).
Nanotechnology
based
use
organic
molecules
(chitosan,
liposomes)
inorganic
(superparamagnetic
iron
oxide
nanoparticles)
carriers
active
substances.
The
main
aim
transport
prolonged
retention
drug
target
tissue,
which
increases
efficacy
substance.
This
review
discusses
numerous
types
nanoparticles
(including
chitosan,
polymeric
nanoparticles,
liposomes,
protein
nanoparticles),
targeting
mechanisms,
approved
nanotherapeutics
with
oncological
implications
treatment.
We
also
present
nanoformulation
applications
phototherapy,
gene
Moreover,
we
summarise
perspectives,
advantages,
clinical
translation.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 72 - 72
Published: Jan. 7, 2025
Liver
cancer
is
a
prevalent
form
of
carcinoma
worldwide.
A
novel
chitosan-coated
optimized
formulation
capped
with
irradiated
silver
nanoparticles
(INops)
was
fabricated
to
boost
the
anti-malignant
impact
rosuvastatin
calcium
(RC).
Using
23-factorial
design,
eight
formulations
were
produced
using
solvent
evaporation
process.
The
characterized
in
vitro
identify
optimal
(Nop).
FTIR
spectra
showed
that
fingerprint
region
not
superimposed
drug;
DSC
thermal
analysis
depicted
negligible
peak
shift;
and
XRPD
diffractograms
revealed
disappearance
typical
drug
peaks.
Nop
had
an
entrapment
efficiency
percent
(EE%)
86.2%,
polydispersity
index
(PDI)
0.254,
zeta
potential
(ZP)
−35.3
mV,
release
after
12
h
(Q12)
55.6%.
(CS.Nop)
significant
mucoadhesive
strength
1.7-fold
greater
than
Nop.
Physical
stability
CS.Nop
alterations
VS,
ZP,
PDI,
retention
(DR)
at
4
°C.
highest
inhibition
effect
on
cells
(97.12%)
compared
(CS.Nop;
81.64)
(CS.Nop.AgNPs;
92.41).
bioavailability
CS-Nop
4.95-fold
RC,
residence
time
about
twice
free
drug.
has
displayed
strong
vitro–in
vivo
correlation
R2
0.9887.
authors
could
propose
INop
serve
as
advanced
platform
improve
oral
enhance
hepatic
recovery.
