Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment DOI

Raffaella Villa,

Ya‐Ping Shiau,

Sohaib Mahri

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: May 7, 2025

Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles shown promise enhancing drug delivery improving activation, with for numerous modifications tailor them specific environments or targets. Integrating nanoplatforms offers a promising avenue overcome these hurdles, treatment outcomes reducing adverse effects. By delivery, targeting, modulation, can unlock full of cancer immunotherapy. This review explores role addressing immunotherapy outcomes, examining various types nanoplatforms. Understanding mechanisms immunomodulation through nanoplatform deliveries is crucial. We discuss how interact tumor microenvironment, modulate tumor-associated macrophages regulatory T cells, activate cells directly, enhance antigen presentation, promote immunological memory. Further benefits include combination approaches integrating chemotherapy, radiotherapy, phototherapy. Immunotherapy relatively new approach, but clinical studies already utilize nanoplatform-based results. aims provide insights into pave way more effective personalized strategies.

Language: Английский

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives DOI Open Access
Sanja Petrović, Bogdan Biță, Marcela Elisabeta Barbinta-Patrascu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

Citations

25
Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration DOI Creative Commons
Zahra Razavi,

Seyed Sina Alizadeh,

F. S. Razavi

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186

Published: Jan. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Language: Английский

Citations

10
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Mahesh Kumar Yadab

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

Citations

2
Biomimetic Nanoparticle Based Targeted mRNA Vaccine Delivery as a Novel Therapy for Glioblastoma Multiforme DOI
Tanvir Ahmed,

Kazi Tasnuva Alam

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: Feb. 21, 2025

Language: Английский

Citations

1
A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential DOI
Raghu Solanki, Laxminarayan Rawat, Saba Tabasum

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

1
Clinical Applications of Targeted Nanomaterials DOI Creative Commons

Ankesh Kumar,

SK Shahvej,

Pankaj Yadav

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 379 - 379

Published: March 17, 2025

Targeted nanomaterials are at the forefront of advancements in nanomedicine due to their unique and versatile properties. These include nanoscale size, shape, surface chemistry, mechanical flexibility, fluorescence, optical behavior, magnetic electronic characteristics, as well biocompatibility biodegradability. attributes enable application across diverse fields, including drug delivery. This review explores fundamental characteristics emphasizes importance clinical applications. It further delves into methodologies for nanoparticle programming alongside discussions on trials case studies. We discussed some promising nanomaterials, such polymeric nanoparticles, carbon-based metallic role biomedical underscores significant translating applications highlights potential these innovative approaches revolutionizing medical field.

Language: Английский

Citations

1
Comprehensive insights of etiological drivers of hepatocellular carcinoma: Fostering targeted nano delivery to anti-cancer regimes DOI
Dipanjan Ghosh, Aharna Guin, Ashok Kumar

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189318 - 189318

Published: April 1, 2025

Language: Английский

Citations

1
Nanocarriers for targeted drug delivery in the vascular system: focus on endothelium DOI Creative Commons

Xiuxiu Cong,

Zebin Zhang, He Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 12, 2024

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics, and modulating inflammatory responses. Nanocarriers hold transformative potential for precise drug delivery within the system, particularly targeting ECs therapeutic purposes. However, complex interactions between nanocarriers present significant challenges development clinical translation of nanotherapeutics. This review assesses recent advancements key strategies employing to ECs. It suggested that through physicochemical design surface modifications, can enhance specificity improve internalization efficiency Additionally, we elaborated on applications specifically designed treatment cardiovascular diseases, cancer metastasis, disorders. Despite these advancements, safety concerns, complexity vivo processes, challenge achieving subcellular remain obstacles effective with nanocarriers. A comprehensive understanding endothelial cell biology its interaction is crucial realizing full targeted systems.

Language: Английский

Citations

9
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach DOI Creative Commons

Ehsan Bitaraf Haghighi,

Samira Sadat Abolmaali, Ali Dehshahri

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation poor cellular uptake, requiring effective delivery systems. Lipid nanoparticles (LNPs) have emerged a leading choice in vivo delivery, offering protection against degradation, enhanced facilitation of endosomal escape. LNPs encounter numerous challenges targeted vivo, demanding advanced particle engineering, surface functionalization with targeting ligands, profound comprehension the biological milieu which they function. This review explores structural physicochemical characteristics LNPs, in-vivo fate, customization therapeutics. We highlight quality-by-design (QbD) approach beyond liver, focusing on biodistribution, immunogenicity, toxicity. In addition, we explored current strategies associated ensuring repeated-dose efficacy, safety, tissue-specific gene delivery. Furthermore, provide insights into clinical applications various classes diseases finally prospects

Language: Английский

Citations

8
Nanomedicine in Bladder Cancer Therapy DOI Open Access
Adrianna Winnicka, Joanna Brzeszczyńska, Joanna Saluk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10388 - 10388

Published: Sept. 26, 2024

Bladder cancer (BC) is one of the most common malignant neoplasms genitourinary system. Traditional BC therapies include chemotherapy, targeted therapy, and immunotherapy. However, limitations such as lack specificity, cytotoxicity, multidrug resistance pose serious challenges to benefits therapies. Consequently, current studies focus on search for new therapeutic solutions. In recent years, there has been a growing interest in using nanotechnology treatment both non-invasive (NMIBC) invasive bladder (MIBC). Nanotechnology based use organic molecules (chitosan, liposomes) inorganic (superparamagnetic iron oxide nanoparticles) carriers active substances. The main aim transport prolonged retention drug target tissue, which increases efficacy substance. This review discusses numerous types nanoparticles (including chitosan, polymeric nanoparticles, liposomes, protein nanoparticles), targeting mechanisms, approved nanotherapeutics with oncological implications treatment. We also present nanoformulation applications phototherapy, gene Moreover, we summarise perspectives, advantages, clinical translation.

Language: Английский

Citations

5