Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

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PROTACs coupled with oligonucleotides to tackle the undruggable

Bioanalysis, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Feb. 3, 2025

Undruggable targets account for roughly 85% of human disease-related and represent a category therapeutic that are difficult to tackle with traditional methods, but their considerable clinical importance. These generally defined by planar functional interfaces the absence efficient ligand-binding pockets, making them unattainable conventional pharmaceutical strategies. The advent oligonucleotide-based proteolysis-targeting chimeras (PROTACs) has instilled renewed optimism in addressing these challenges. PROTACs facilitate targeted degradation undruggable entities, including transcription factors (TFs) RNA-binding proteins (RBPs), via proteasome-dependent mechanisms, thereby presenting novel approaches diseases linked targets. This review offers an in-depth examination recent progress integration PROTAC technology oligonucleotides target traditionally proteins, emphasizing design principles mechanisms action innovative PROTACs.

Language: Английский

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Delivery of nanocarriers with dissolvable microneedles for skin treatments: approaches and challenges

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106836 - 106836

Published: March 1, 2025

Language: Английский

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CRISPR-Cas System: Novel Experimental Therapeutic and Diagnostic Approaches for Chronic Liver Diseases

Published: April 8, 2025

Review CRISPR-Cas System: Novel Experimental Therapeutic and Diagnostic Approaches for Chronic Liver Diseases Teja Naveen Sata Senthil Kumar Venugopal * Faculty of Life Sciences Biotechnology, South Asian University, New Delhi 110068, India Correspondence: [email protected]; Tel.: +91-1135656620; Fax: +91-1124122511 Received: 7 February 2025; Accepted: 26 Published: 8 April 2025 Abstract: liver disease (CLD), a significant ailment, contributes to nearly two million deaths annually. CLD can be caused by alcohol consumption, fat, viral infections, genetic disorders. Accurate diagnosis application therapeutics are crucial strategies enhancing the management CLD. The system, originally prokaryotic innate immunity mechanism, has evolved into current-generation tool therapeutic diagnostic applications. cis-cleavage feature system involves crRNA-guided specific target cleavage. This mechanism is utilized development therapeutics. Few systems possess additional trans-cleavage, which non-specific cleavage, also known as collateral unique exploited generate diagnostics. In hepatitis, CRIPSR-Cas have been concurrently applied reported genome-targeted detection systems. Research on alcoholic non-alcoholic fatty diseases mainly focuses targeting progression factors. Also, CRISPR-Cas-based gene editing used manage hepatocellular carcinoma, oncogene-targeted therapies biomarker Various non-viral delivery proposed developing Despite limited progress, potential broader in review describes comprehensive use experimental approaches

Language: Английский

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CircTADA2A stabilizes p53 via interacting with TRIM28 and suppresses the maintenance of FLT3-ITD acute myeloid leukemia

Leukemia, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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The Protein Corona Paradox: Challenges in Achieving True Biomimetics in Nanomedicines

Biomimetics, Journal Year: 2025, Volume and Issue: 10(5), P. 276 - 276

Published: April 29, 2025

Nanoparticles introduced into biological environments rapidly acquire a coating of biomolecules, forming biocorona that dictates their fate. Among these proteins play key role, but interaction with nanoparticles during the adsorption process often leads to unfolding and functional loss. Evidence suggests protein denaturation within alters cellular recognition, signaling pathways, immune responses, significant implications for nanomedicine nanotoxicology. This review explores dynamic nature corona, emphasizing influence local milieu on its stability. We synthesize findings from studies examining physicochemical properties nanoparticles—such as surface charge, hydrophobicity, curvature—that contribute structural perturbations. Understanding factors governing stability nanoparticle surfaces is essential designing nanomaterials improved targeting, biocompatibility, controlled interactions. underscores importance preserving conformational integrity in development biomedical applications.

Language: Английский

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From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

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Preparation of atorvastatin calcium-loaded liposomes using thin-film hydration and coaxial micromixing methods: A comparative study

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100309 - 100309

Published: Nov. 29, 2024

Language: Английский

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