Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1753 - 1753
Published: Oct. 25, 2024
In this study, we aimed to explore the oral bacteria and fungi that can help discern squamous cell carcinoma (OSCC) investigate correlations between multiple key pathogens.
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489
Published: July 27, 2024
Language: Английский
Citations
10
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997
Published: Aug. 28, 2024
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4092 - 4092
Published: April 7, 2024
We explore the possibility that defects in genes associated with response and repair of DNA double strand breaks predispose oral potentially malignant disorders (OPMD) to undergo transformation squamous cell carcinoma (OSCC). Defects homologous recombination/Fanconi anemia (HR/FA), but not non-homologous end joining, causes pathway appear be consistent features familial conditions are predisposed OSCC (FA, Bloom’s syndrome, Ataxia Telangiectasia); this is true for occurs young patients, sometimes little/no exposure classical risk factors. Even Dyskeratosis Congenita, a disorder telomerase complex also OSCC, attempts at maintaining telomere length involve shared HR genes. HR/FA therefore pivotal OSCC. There some evidence abnormalities sporadic cases OPMD provide data showing overexpression cell-cycle-dependent manner series OPMD-derived immortal keratinocyte lines compared their mortal counterparts. The observations study argue strongly an important role HA/FA development
Language: Английский
Citations
4
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: Jan. 27, 2025
The oral microbiota is a diverse and complex community that maintains delicate balance. When this balance disturbed, it can lead to acute chronic infectious diseases such as dental caries periodontitis, significantly affecting people's quality of life. Developing new antimicrobial strategy deal with the increasing microbial variability resistance important. Cold atmospheric plasma (CAP), fourth state matter, has gradually become hot topic in field biomedicine due its good antibacterial, anti-inflammatory, anti-tumor capabilities. It expected major asset regulation microbiota. We conducted search PubMed, Medline, Wiley databases, focusing on studies related CAP pathogenic microorganisms. explored biological effects summarized mechanisms behind it. Numerous articles have shown potent effect against common pathogens, including bacteria, fungi, viruses, primarily synergy various factors, especially reactive oxygen nitrogen species. effective microorganisms, anticipated offer approach treating diseases. future objective precisely adjust parameters ensure safety efficacy, subsequently develop comprehensive treatment protocol. Achieving crucial for clinical application CAP, further research necessary.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 26, 2025
A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106489 - 106489
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3621 - 3621
Published: April 11, 2025
Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix (ECM) remodeling, regulating a wide range of cellular and immune processes both homeostatic pathological conditions. Host–microbiota interactions play critical role maintaining ECM balance; however, during dysbiosis, this regulation is disrupted, leading to compromised barrier integrity, pathogen translocation into circulation, the development systemic diseases cancer. This review highlights bidirectional relationship between MMP expression/activity microbiota emphasizing tissue-specific alterations activity that contribute disease progression. In addition, it integrates interdisciplinary evidence illustrate MMP-dependent mechanisms underlying various pathologies associated with oral gut microbiome including long-range effects through gut–skin gut–brain axes. Thus, introduces emerging field MatrixBiome, which explores complex ECM, microbiota, host tissues. Finally, also outlines therapeutic strategies modulate levels, either indirectly microbiome-targeted approaches (e.g., prebiotics, probiotics, postbiotics) or directly using inhibitors, offering promising avenues for future clinical interventions.
Language: Английский
Citations
0
Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 61, P. 103406 - 103406
Published: Oct. 1, 2024
Language: Английский
Citations
3
Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32259 - e32259
Published: May 31, 2024
An association between periodontal disease and oral squamous cell carcinoma (OSCC) has been recognized. However, there is no causal relationship the two. The polymicrobial etiology of confirmed, so are proven etiological factors for OSCC. Inflammation lies at core pathogenesis induced by putative microbes. OSCC inflammatory overtures in its pathobiology. Bacterial species involved have extensively documented validated. microbial profile explored with specific conclusions. scientific reasoning to link a common signature that connects led many studies but not provided conclusive evidence. Therefore, it would be beneficial know status any plausible microbiota having similarity This brief review attempted clarify existence dysbiotic "fingerprint" may these two diseases. examined literature focused objective identifying profiles could provide insights into pathogen commonality. concluded great diversity association, important bacterial correlate forthcoming.
Language: Английский
Citations
2
Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)
Published: Jan. 1, 2024
Abstract Oral squamous cell carcinoma (OSCC) is the most common malignancy among head and neck carcinomas. Targeted therapy plays a crucial role in treatment of OSCC. However, new more targets are still needed to develop. Stanniocalcin-1 (STC-1) glycoprotein hormone that affects progression cancers. potential STC-1 OSCC remains be explored. Here, we aimed elucidate We revealed was highly expressed tissues correlated with poor patient prognosis. Knockdown significantly suppressed growth cells restrained glycolysis by reducing glucose consumption, ATP production, lactate levels. Mechanistically, ablation inhibited PI3K/Akt pathway, phosphorylation levels PI3K Akt. In conclusion, depletion via pathway has serve as therapeutic target for
Language: Английский
Citations
1