Acute compartment syndrome due to skeletal muscle metastases from poorly differentiated upper gastrointestinal adenocarcinoma: a case report DOI Creative Commons

R.P. Gentry,

Prince Mohan,

Ahmed I. Abdelkader

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Background Acute compartment syndrome (ACS) is characterized by increased pressure within the fascial network of any muscle, leading to impaired circulation and potential myonecrosis. Very rarely, soft tissue infiltration metastatic disease can cause localized swelling that increases intercompartmental pressures. We report an unusual case invasive, poorly differentiated upper gastrointestinal adenocarcinoma presented acute lower extremity subsequent kidney injury (AKI) caused skeletal muscle metastasis. Case Presentation A 52-year-old male hospital with rapid onset unilateral right leg pain tense edema accompanied myonecrosis no explicable etiology complicated AKI. Surgical fasciotomy biopsy yielded non-small cell adenocarcinoma. CT imaging identified diffuse adenopathy along abnormal thickening distal esophagus, gastroesophageal (GE) junction, gastric cardia. Further investigation via esophagogastroduodenoscopy (EGD) revealed exophytic mass in esophagus extending into stomach. This lesion was confirmed as primary invasive (UGI) Conclusion highlights need for clinicians implement high-risk screening UGI cancers consider metastasis a nontraumatic ACS. It emphasizes importance interdisciplinary collaboration managing such complex cases role timely surgical oncological intervention preventing long-term complications

Language: Английский

Prognosis and Treatment of Gastric Cancer: A 2024 Update DOI Open Access
Claudia Burz,

Vlad Pop,

Ciprian Silaghi

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1708 - 1708

Published: April 27, 2024

Due to the high death rate associated with gastric cancer, a great deal of research has been conducted on this disease. The goal paper was start trimestral review 2024 for year that had just started. scientific literature from 1 January chosen consideration guidelines European Society Medical Oncology (ESMO), which are updated new findings but not systematically reviewed annually. We used search term “gastric cancer” find most current publications in PubMed database related prognosis and treatment cancer. As previously said, only articles satisfied inclusion criteria were those 2024. Articles case reports eliminated since they nothing do our research. cancer is focus majority primary axes include surgery immunonutrition, immunotherapy Helicobacter pylori, therapeutic targets. Patients GC may experience less psychological, social, financial hardship if recently identified markers discovered circulation better assessed validated. This could be achieved by either including an artificial intelligence-based diagnostic score or using them conjunction traditional methods. rising GC, funding into diagnosis, prognosis, therapy, targets essential.

Language: Английский

Citations

22
Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes DOI Open Access

Xiaochuan Dong,

Yanyan Xie, Wenxi Chen

et al.

Translational Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: 10, P. 7 - 7

Published: Jan. 1, 2025

Gastrointestinal adenocarcinomas (GIACs) are common malignant tumors with poor prognosis in the world. Ferroptosis, characterized by accumulation of intracellular iron and lipid reactive oxygen species, emerges as a pivotal process tumorigenesis cancer advancement. However, implications ferroptosis-related genes GIAC remain to be elucidated. This study aimed at exploring potential role on treatment GIAC. In our study, comprehensive clinical, transcriptomic, and/or genomic data were acquired from The Cancer Genome Atlas (TCGA), Cell Line Encyclopedia (CCLE), Genomics Drug Sensitivity (GDSC), Gene Expression Omnibus (GEO). We formulated ferroptosis-score within TCGA cohort through gene set variation analysis (GSVA) subsequently validated 4 GEO datasets (GSE84437, GSE17536, GSE103479, GSE19417). sensitivity immunotherapy efficacy analyzed GDSC dataset PRJEB25780 cohort, respectively. was significantly associated favorable overall survival both training [TCGA: P=0.003; hazard ratio (HR), 0.67, 95% confidence interval (95% CI): 0.52-0.87] across four validation cohorts (GSE17536: P=0.03; HR, 0.57, CI: 0.34-0.96; GSE19417: P=0.047; 0.53, 0.28-1.01; GSE84437: P=0.004; 0.68, 0.51-0.90; GSE103479: 0.55, 0.32-0.96). Furthermore, correlated activation DNA damage repair pathway resistance cisplatin. Notably, GIACs low ferroptosis-scores exhibited heightened expression immune checkpoint molecules such programmed death-(ligand) 1 cytotoxic T lymphocyte antigen-4, elevated densities tumor-infiltrating CD8+ cells, response pembrolizumab monotherapy. Our findings delineated clinical relevance demonstrated utility predicting effectiveness.

Language: Английский

Citations

0
Astaxanthin in cancer therapy and prevention (Review) DOI Open Access
Chiara Copat, Claudia Favara, Marianna Flora Tomasello

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(4)

Published: Feb. 14, 2025

Astaxanthin (AXT), a carotenoid primarily derived from marine organisms such as shrimp, krill and the microalga Haematococcus pluvialis, has gained significant attention for its potent antioxidant, anti‑inflammatory anti‑proliferative properties. The present comprehensive review explored role of AXT in cancer prevention treatment, emphasizing cytotoxic mechanisms modulation key molecular pathways involved progression. demonstrated efficacy across variety types, including nervous system, breast gastrointestinal cancers, through ability to induce apoptosis, inhibit metastasis disrupt cell growth. detailed both in vitro vivo studies highlighting effectiveness sensitizing cells chemotherapy, thereby enhancing therapeutic outcomes potentially reducing treatment‑related side effects. incorporation nanoparticle‑based delivery systems further improved bioavailability targeted action, showcasing potential advanced therapies. However, despite promising experimental results, more clinical trials are necessary validate safety human populations. Such research would help standardize dosing, confirm interactions with conventional treatments support integration into oncology natural, complementary approach existing treatments.

Language: Английский

Citations

0
Acute compartment syndrome due to skeletal muscle metastases from poorly differentiated upper gastrointestinal adenocarcinoma: a case report DOI Creative Commons

R.P. Gentry,

Prince Mohan, Ahmed Kamal

et al.

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

Abstract Background Acute compartment syndrome (ACS) is characterized by increased pressure within the fascial network of any muscle, leading to impaired circulation and potential myonecrosis. Very rarely, soft tissue infiltration metastatic disease can cause localized swelling that increases intercompartmental pressures. We report an unusual case invasive, poorly differentiated upper gastrointestinal adenocarcinoma presented acute lower extremity subsequent kidney injury (AKI) caused myonecrosis-induced cast nephropathy. Case Presentation A 52-year-old male hospital with rapid onset unilateral right leg pain tense edema accompanied myonecrosis no explicable etiology complicated AKI. Surgical fasciotomy muscle biopsy yielded non-small cell adenocarcinoma. CT imaging identified diffuse adenopathy along abnormal thickening distal esophagus, gastroesophageal (GE) junction, gastric cardia. Further investigation via esophagogastroduodenoscopy (EGD) revealed exophytic mass in esophagus extending into stomach. This lesion was confirmed as primary invasive (UGI) Conclusion highlights need for clinicians implement high-risk screening UGI cancers consider skeletal metastasis a nontraumatic ACS. It emphasizes importance interdisciplinary collaboration managing such complex cases role timely surgical oncological intervention preventing long-term complications Furthermore, it use more efficient specific MR techniques diagnose ambiguous

Language: Английский

Citations

0
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation DOI
Yan Niu, Chunyu Liu, Lizhou Jia

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 8, 2025

Language: Английский

Citations

0
ChatGPT-4o outperforms Gemini Advanced in Assisting Multidisciplinary Decision-Making for Advanced Gastric Cancer DOI
Huizi Li,

Chang‐Ming Huang,

Kuntang Liu

et al.

European Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 51(8), P. 110096 - 110096

Published: April 24, 2025

Language: Английский

Citations

0
Pathologic complete response after Sintilimab combined with FOLFOX therapy in MSI-H type patients with locally advanced GC: a case report DOI Creative Commons
Peijian Wang,

Yuanhui Gu,

Yi Lin

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

As one of the most common gastrointestinal tumors, Gastric Cancer (GC) poses a serious threat to human health due its high morbidity and mortality. The current treatment strategy is comprehensive program mainly based on surgery, especially for advanced GC patients. emergence immune checkpoint inhibitors has completely changed this status quo, synergistic effect neoadjuvant immunotherapy combined with chemotherapy significantly improved resection radical rate overall survival patients local GC. We present case locally (cT4N0Mx) microsatellite instability (MSI-H) PD-L1 Combined Positive Score (CPS)=2. patient received therapy Sintilimab FOLFOX (folinic acid (leucovorin), 5-fluorouracil (5-FU), oxaliplatin), reduced tumor volume after 3 cycles treatment. Then she underwent subtotal gastrectomy gastrojejunostomy D2 lymph node dissection. postoperative pathological results showed that no cancerous tissue remained in tissue, pathologic complete response (pCR) was achieved. first cycle adjuvant same protocol surgery. During therapy, experienced side effects such as dyspepsia, nausea mild myelosuppression. Therefore, potential be an effective option resectable MSI-H

Language: Английский

Citations

0
Prognostic Influence of Galectin-1 in Gastric Adenocarcinoma DOI Creative Commons
Cristina Díaz del Arco, Lourdes Estrada Muñoz, Mercedes Nieto

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1508 - 1508

Published: July 7, 2024

Galectin-1 (Gal-1), a member of the human lectin family, has garnered attention for its association with aggressive behavior in tumors, prompting research into development targeted drugs. This study aims to assess staining pattern and prognostic significance Gal-1 immunohistochemical expression homogeneous cohort Western patients gastric cancer (GC). A total 149 cases were included tissue microarrays constructed. Stromal was observed some extent most displaying cytoplasmic pattern. Cases stromal overexpression showed significantly more necrosis, lymphovascular invasion, advanced pTNM stages, recurrences, cancer-related deaths. Epithelial present 63.8% cases, primarily exhibiting pattern, associated peritumoral lymphocytic infiltration, tumor-related death. Kaplan/Meier curves cancer-specific survival (CSS) revealed worse prognosis tumors or epithelial overexpression. Furthermore, stratified stage III distinct subgroups. In multivariable analysis, increased emerged as an independent factor CSS. These findings underscore relevance suggest potential target drug GC.

Language: Английский

Citations

1
Análise dos Indicadores de Neoplasia Maligna de Estômago no Brasil, no Período entre 2013 e 2023 DOI Creative Commons

Igor Gabriel Mendes Costa,

João Gabriel Siqueira Mendes,

Elkjaer Liniker Lourenço

et al.

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(8), P. 47 - 58

Published: Aug. 1, 2024

INTRODUÇÃO: A neoplasia maligna de estômago, ou câncer gástrico, refere-se ao crescimento desordenado células malignas no revestimento do resultando em um tumor que pode invadir tecidos adjacentes e se disseminar para outras partes corpo. Considerada uma das principais causas mortalidade por mundialmente, essa condição é especialmente prevalente países desenvolvimento. Este artigo analisará as internações, óbitos taxa associados a condição, destacando importância diagnóstico precoce intervenções terapêuticas avançadas. OBJETIVO: estudo visa quantificar analisar taxas estômago Brasil. METODOLOGIA: Trata-se retrospectivo com abordagem quantitativa, realizado partir coleta dados pelo Sistema Informações Hospitalares SUS (SIH/SUS), disponibilizados pela base secundária Departamento Informática Único Saúde (TABNET/DATASUS). Os estudados referiam-se às aos à Brasil período entre janeiro 2013 dezembro 2023. análise foi realizada estatística descritiva, tabulação planilha eletrônica programa Microsoft Excel 2016 disposta tabelas Word 10. RESULTADOS: No 2023, foram registradas 316.228 internações Região Sudeste apresentou maior porcentagem (43,25%), seguida Sul (24,02%). mesmo período, ocorreram 48.785 óbitos, concentração também na (48,28%). variou 12,16 22,39 Norte. CONCLUSÃO: Portanto, evidencia disparidades regionais significativas manejo da Brasil, necessidade urgente políticas públicas melhorar o acesso tratamento, nas regiões altas mortalidade, como Estratégias específicas são cruciais reduzir desigualdades cuidado tratamento dessa promovendo distribuição mais equitativa dos recursos saúde melhorando os resultados pacientes todo país.

Citations

0
Acute compartment syndrome due to skeletal muscle metastases from poorly differentiated upper gastrointestinal adenocarcinoma: a case report DOI Creative Commons

R.P. Gentry,

Prince Mohan,

Ahmed I. Abdelkader

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Background Acute compartment syndrome (ACS) is characterized by increased pressure within the fascial network of any muscle, leading to impaired circulation and potential myonecrosis. Very rarely, soft tissue infiltration metastatic disease can cause localized swelling that increases intercompartmental pressures. We report an unusual case invasive, poorly differentiated upper gastrointestinal adenocarcinoma presented acute lower extremity subsequent kidney injury (AKI) caused skeletal muscle metastasis. Case Presentation A 52-year-old male hospital with rapid onset unilateral right leg pain tense edema accompanied myonecrosis no explicable etiology complicated AKI. Surgical fasciotomy biopsy yielded non-small cell adenocarcinoma. CT imaging identified diffuse adenopathy along abnormal thickening distal esophagus, gastroesophageal (GE) junction, gastric cardia. Further investigation via esophagogastroduodenoscopy (EGD) revealed exophytic mass in esophagus extending into stomach. This lesion was confirmed as primary invasive (UGI) Conclusion highlights need for clinicians implement high-risk screening UGI cancers consider metastasis a nontraumatic ACS. It emphasizes importance interdisciplinary collaboration managing such complex cases role timely surgical oncological intervention preventing long-term complications

Language: Английский

Citations

0