A comprehensive analysis of the expression and prognostic significance of signal transducers and activators of transcription family in gastric cancer patients DOI Creative Commons
Denggang Fu, Biyu Zhang, Jinghui Sun

et al.

Egyptian Journal of Medical Human Genetics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 23, 2024

Abstract Background Understanding the role of STAT family in gastric cancer (GC) is essential for developing targeted therapies and improving patient outcomes. However, comprehensive analysis expression its prognostic significance GC limited. This study aims to address this gap by examining normal tissues evaluating value across clinical subgroups. Methods mRNA levels were compared between tumor using fold change analysis. Kaplan–Meier curves assessed correlation outcomes, with statistical determined Log-rank test hazard ratios (HR) 95% confidence intervals. Subset analyses evaluated subtypes value, including patients oncogenic mutations. Results Most members, except STAT4, showed increased tissues, consistent various subgroups, suggesting a pathogenesis. revealed STATs GC. High STAT1 was associated improved overall survival (OS), first progression (FP), post-progression (PPS), indicating favorable prognosis. In contrast, elevated STAT5A, STAT5B, STAT6 correlated poor Subgroup highlighted different histological subtypes, particularly intestinal-type Additionally, had differential implications based on HER2 status. HER2-positive high worse OS FP rates, while HER2-negative better Conclusions provides valuable insights into patterns their The upregulation STATs, suggests involvement oncogenesis. Notably, marker, correlates These findings underscore potential as markers GC, guiding personalized treatment strategies

Language: Английский

Hydrogels with Essential Oils: Recent Advances in Designs and Applications DOI Creative Commons
Mariana Chelu

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 636 - 636

Published: Sept. 30, 2024

The innovative fusion of essential oils with hydrogel engineering offers an optimistic perspective for the design and development next-generation materials incorporating natural bioactive compounds. This review provides a comprehensive overview latest advances in use hydrogels containing biomedical, dental, cosmetic, food, food packaging, restoration cultural heritage applications. Polymeric sources, methods obtaining, cross-linking techniques, functional properties are discussed. unique characteristics polymer agents highlighted. These include biocompatibility, nontoxicity, effective antibacterial activity, control sustained prolonged release active substances, optimal porosity, outstanding cytocompatibility. Additionally, specific distinctive explored, along their extraction encapsulation methods. advantages disadvantages these also We have considered limitations due to volatility, solubility, environmental factors, stability. importance loading hydrogels, stability, biological activity is analyzed. highlights through in-depth analysis, recent innovations, challenges, future prospects encapsulated potential multiple applications including biomedicine, dentistry, cosmetics, conservation.

Language: Английский

Citations

11
The Importance of Extracellular Vesicle Screening in Gastric Cancer: A 2024 Update DOI Open Access
Vasile Bințințan, Claudia Burz,

Irena Pintea

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2574 - 2574

Published: July 18, 2024

Extracellular vesicles, or EVs, are membrane-bound nanocompartments produced by tumor cells. EVs carry proteins and nucleic acids from host cells to target cells, where they can transfer lipids, proteomes, genetic material change the function of serve as reservoirs for mobile cellular signals. The collection using less invasive processes has piqued interest many researchers. Exosomes substances that suppress immune system. If results exosome screening negative, immunotherapy will be beneficial GC patients. In this study, we provide an update on based ongoing review papers clinical trials.

Language: Английский

Citations

5
Astaxanthin in cancer therapy and prevention (Review) DOI Open Access
Chiara Copat, Claudia Favara, Marianna Flora Tomasello

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(4)

Published: Feb. 14, 2025

Astaxanthin (AXT), a carotenoid primarily derived from marine organisms such as shrimp, krill and the microalga Haematococcus pluvialis, has gained significant attention for its potent antioxidant, anti‑inflammatory anti‑proliferative properties. The present comprehensive review explored role of AXT in cancer prevention treatment, emphasizing cytotoxic mechanisms modulation key molecular pathways involved progression. demonstrated efficacy across variety types, including nervous system, breast gastrointestinal cancers, through ability to induce apoptosis, inhibit metastasis disrupt cell growth. detailed both in vitro vivo studies highlighting effectiveness sensitizing cells chemotherapy, thereby enhancing therapeutic outcomes potentially reducing treatment‑related side effects. incorporation nanoparticle‑based delivery systems further improved bioavailability targeted action, showcasing potential advanced therapies. However, despite promising experimental results, more clinical trials are necessary validate safety human populations. Such research would help standardize dosing, confirm interactions with conventional treatments support integration into oncology natural, complementary approach existing treatments.

Language: Английский

Citations

0
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation DOI
Yan Niu, Chunyu Liu, Lizhou Jia

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 8, 2025

Language: Английский

Citations

0
Gastrointestinal cancer: Current status of preclinical research DOI
Nariman Shahid, Sana Hanif,

Muhammad Ali Syed

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 317 - 348

Published: Jan. 1, 2025

Language: Английский

Citations

0
Prognostic Impact of Klintrup–Mäkinen (KM) Score in Gastric Cancer and Its Association with Pathological Parameters DOI Creative Commons

Andreea-Raluca Cozac-Szőke,

Georgian-Nicolae Radu,

Anca Negovan

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 715 - 715

Published: April 13, 2025

Background and Objectives: Gastric cancer (GC) remains a significant global health challenge with poor prognosis. This study aimed to evaluate the association between Klintrup–Mäkinen (KM) inflammatory infiltrate grading clinicopathological features in gastric patients, investigating its potential as prognostic marker. Material Methods: retrospective analyzed 133 adenocarcinoma patients diagnosed 2020 2021 at County Clinical Hospital Târgu Mureș, Romania. Patients were divided into two groups based on KM grades: low (grades 0–1, n = 62) high 2–3, 71). Clinicopathological characteristics survival outcomes compared groups. Results: Demographic similar grades demonstrated significantly more aggressive tumor features, including higher prevalence of Borrmann classification types III-IV (75.8% vs. 54.9%, p 0.01), poorly differentiated histology (74.1% 33.8%, < 0.0001), advanced T stage (93.5% 80.2%, 0.04), lymph node involvement (87% 60.5%, 0.0008). group also exhibited rates lymphatic invasion (79% 50.7%, 0.001), venous (51.6% 30.9%, 0.02), perineural (50% 22.5%, positive surgical margins (32.2% 15.4%, 0.02). Survival analysis revealed hazard ratio 1.642 (95% CI: 1.02–2.62) for those grades. Conclusions: Low are associated poorer prognosis GC patients. The score may serve valuable, cost-effective histological marker assessing aggressiveness could aid risk stratification when applied routine H&E-stained slides. While it does not replace immunohistochemical or molecular analyses, integrating pathological assessment enhance accuracy support identifying who might benefit from immunotherapy.

Language: Английский

Citations

0
Portrayal of the Complex Molecular Landscape of Multidrug Resistance in Gastric Cancer: Unveiling the Potential Targets DOI

S. Biswas,

Riya Kanodia,

Suman Seervi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114580 - 114580

Published: April 1, 2025

Language: Английский

Citations

0
Helicobacter pylori Infection in Patients with Gastric Cancer: A 2024 Update DOI Open Access
Claudia Burz,

Vlad Pop,

Ciprian Silaghi

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(11), P. 1958 - 1958

Published: May 22, 2024

Numerous studies have been performed on Helicobacter pylori infection because of the high death rate linked to this illness and gastric cancer. An update key developments in recent years investigation cancer is goal review. Using search term “Helicobacter pylori, cancer”, PubMed database was searched. Only papers published 2024 fulfilled inclusion criteria. Because case report were not part our investigation, they satisfied exclusion Most research variable genes guided by genetics determine potential treatments. Studies clinical treatments for eradication H. with promising therapeutic options are needed. We found fewest related immunopathology infection, which still unknown. In conclusion, priority should be given kind research.

Language: Английский

Citations

2
Targeting LINC00665/miR-199b-5p/SERPINE1 axis to inhibit trastuzumab resistance and tumorigenesis of gastric cancer via PI3K/AKt pathway DOI Creative Commons
Bingyu Wang, Wenbo Liu,

Buyun Song

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 153 - 162

Published: July 31, 2024

Long noncoding RNAs (lncRNAs) serve as critical mediators of tumor progression and drug resistance in cancer. Herein, we identified a lncRNA, LINC00665, associated with trastuzumab development gastric cancer (GC). LINC00665 was highly expressed GC tissues high expression correlated poor prognosis. knockdown verified to suppress migration, invasion, GC. Furthermore, found that participates the infiltration naive B cells, mast T follicular helper (Tfh) cells. Mechanistically, confirmed regulate tumorigenesis by activating PI3K/AKt pathway. sponged miR-199b-5p interact SERPINE1 expression, resulting increase phosphorylation AKt, thus participating To summarize, facilitated sponging promoting which further activated signaling; this finding reveals new mechanism modulates

Language: Английский

Citations

2
Predictive Factors of Immunotherapy in Gastric Cancer: A 2024 Update DOI Creative Commons
Vasile Bințințan, Claudia Burz,

Irena Pintea

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(12), P. 1247 - 1247

Published: June 13, 2024

Many studies on gastric cancer treatment have identified predictors of immunotherapy benefits. This article provides an update the major developments in research related to predictive factors for cancer. We used search term “predictive factors, immunotherapy, cancer” find most current publications PubMed database Programmed cell death, genetic, and immunological are main study topics immunotherapy’s Other preventive were also found, including clinical tumor microenvironment imaging extracellular factors. Since there is currently no effective cancer, we strongly propose that these be prioritized.

Language: Английский

Citations

1