Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 200, P. 104407 - 104407
Published: June 2, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 31, 2025
Primary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in initiation progression. However, the specific characteristics of immune clinical significance remain poorly understood. This study included 93 paraffin-embedded tissue samples from 90 patients diagnosed with CNS GCTs. Immunohistochemistry immunofluorescence staining were used to assess infiltration patterns T subsets (CD3+, CD4+, CD8+, Foxp3+) expression levels checkpoints (CTLA-4, PD-1, PD-L1). Additionally, explored relationship between these features patient's prognosis. The revealed that germinomas exhibited significantly higher CD4+ Foxp3+ cells compared non-germinomatous GCTs (NGGCTs). CTLA-4 was detected 58.06% cases, while PD-1 PD-L1 expressed over 90%, elevated NGGCTs. positively correlated checkpoint expression, particularly germinomas. results also highlighted strong immunosuppressive nature GCTs' microenvironment. Furthermore, closely associated Notably, identified as an independent prognostic factor for progression-free survival (PFS) recurrence-free (RFS). Our distinct significant GCTs, revealing highly heterogeneous predictor, offering foundation enhancing risk stratification GCT patients. These findings support potential future applications inhibitors, such monoclonal antibodies.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 908 - 908
Published: July 25, 2024
Post-translational modifications (PTMs) influence protein functionality by modulating stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development progression, especially hepatocellular carcinoma (HCC). This review outlines the of progression HCC. Moreover, we delve into underlying mechanisms HCC highlight compounds that target O-GlcNAc transferase (OGT) O-GlcNAcase (OGA) improve treatment outcomes. Understanding will offer insights potential therapeutic strategies targeting OGT OGA, which could for patients
Language: Английский
Citations
3
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177554 - 177554
Published: March 1, 2025
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 573, P. 120293 - 120293
Published: April 10, 2025
Language: Английский
Citations
0
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge due to its high mortality rate. Hepatocellular and intrahepatic cholangiocarcinoma (ICC) are the two main types of primary liver cancer (PLC), each with own set complexities. Secondary or metastatic is more common than PLC. It frequently observed in malignancies such as colorectal, pancreatic, melanoma, lung, breast cancer. often diagnosed at an advanced stage, making it difficult treat. This highlights need for focused research on early detection effective treatment strategies. review explores epidemiology, risk factors, diagnostic techniques HCC. The development HCC involves various including chronic diseases, hepatitis B C infections, alcohol consumption, obesity, smoking, genetic predispositions. Various invasive non-invasive techniques, biopsy, liquid imaging modalities like ultrasonography, computed tomography scans (CT scans), magnetic resonance (MRI), positron emission (PET) scans, utilized monitoring. Advances technology biomarker have led accurate sensitive methods detection. We also reviewed emerging next-generation sequencing, metabolomics, epigenetic biomarkers, microbiome analysis, which show great potential advancing diagnosis personalized literature provides insights into current state promising future advancements. Ongoing innovation these areas essential improving reducing burden
Language: Английский
Citations
1
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 200, P. 104407 - 104407
Published: June 2, 2024
Language: Английский
Citations
0