Age-associated modulation of TREM1/2- expressing macrophages promotes melanoma progression and metastasis DOI Open Access
Marzia Scortegagna, Rabi Murad, Parinaz Bina

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Aging is a known risk factor for melanoma, yet mechanisms underlying melanoma progression and metastasis in older populations remain largely unexplored. Among the current knowledge gaps how aging alters phenotypes of cells microenvironment. Here we demonstrate that age enriches immunosuppressor tumor microenvironment, which linked to associated with metastasis. cellular enriched by were macrophages tolerogenic phenotype expressing TREM2 dysfunctional CD8-positive an exhausted phenotype, while profibrotic TREM1 depleted. Notably, inhibition decreased growth young but not old mice, whereas prevented lung aged mice. These data identify novel targets may guide aged-dependent immunotherapies.

Language: Английский

Innate immune cells link dietary cues to normal and abnormal metabolic regulation DOI
Peng Zhang, Kosuke Watari, Michael Karin

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: 26(1), P. 29 - 41

Published: Jan. 1, 2025

Language: Английский

Citations

1
TREM2 promotes the proliferation and invasion of renal cell carcinoma cells by inhibiting the P53 signaling pathway DOI Open Access
Liang Zhang,

Zhong Lv,

Qin‐Yu Xu

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(5)

Published: Sept. 6, 2024

Renal cell carcinoma (RCC) is a prevalent malignancy characterized by poor prognosis and high mortality. The role of triggering receptor expressed on myeloid cells-2 (TREM2) in RCC progression has been increasingly recognized, yet its underlying mechanisms remain to be fully elucidated. aim the present study was assess effects TREM2 cells potential mechanisms. Lentiviral transfection used knockdown overexpress cells, expression level evaluated using reverse transcription-quantitative PCR. Cell Counting Kit-8 (CCK-8) 5-ethynyl-2'-deoxyuridine (EdU) assays were proliferation cells. migration invasion wound healing assay Transwell assay, respectively. Western blotting levels TREM2, P53, p-P53, P21 p-P21 or overexpression results demonstrated that significantly higher cancer tissues compared with adjacent normal tissues. CCK-8 EdU inhibited whilst enhanced revealed that, control group, increased whereas decreased In addition, western phosphorylation P53 proteins after conclusion, highly promotes inhibiting signaling pathway. provides new insights into regulatory effect further reveals as therapeutic target for RCC.

Language: Английский

Citations

0
TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives DOI Creative Commons
Alexander B. Sigalov

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

TREM-1 and TREM-2 as Therapeutic Targets: Clinical Challenges Perspectives.

Language: Английский

Citations

0
Age-associated modulation of TREM1/2- expressing macrophages promotes melanoma progression and metastasis DOI Open Access
Marzia Scortegagna, Rabi Murad, Parinaz Bina

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Aging is a known risk factor for melanoma, yet mechanisms underlying melanoma progression and metastasis in older populations remain largely unexplored. Among the current knowledge gaps how aging alters phenotypes of cells microenvironment. Here we demonstrate that age enriches immunosuppressor tumor microenvironment, which linked to associated with metastasis. cellular enriched by were macrophages tolerogenic phenotype expressing TREM2 dysfunctional CD8-positive an exhausted phenotype, while profibrotic TREM1 depleted. Notably, inhibition decreased growth young but not old mice, whereas prevented lung aged mice. These data identify novel targets may guide aged-dependent immunotherapies.

Language: Английский

Citations

0