Risk and Benefit for Basket Trials in Oncology: A Systematic Review and Meta-Analysis DOI Creative Commons
Katarzyna Klaś, Karolina Strzebońska, Łucja Zaborowska

et al.

Targeted Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Oncology research is increasingly adopting new clinical trial models that implement the concept of precision medicine. One these basket design. Basket trials allow treatments to be evaluated across multiple tumor types. Patients recruited share certain molecular characteristics their cancer are predictive benefit from experimental treatment.

Language: Английский

PI3K/AKT/mTOR and PD‑1/CTLA‑4/CD28 pathways as key targets of cancer immunotherapy (Review) DOI Open Access
Shuangcui Wang, Changyu Liu,

Chenxin Yang

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 28(6)

Published: Sept. 26, 2024

T cells play an important role in cancer, and energy metabolism can determine both the proliferation differentiation of cells. The inhibition immune checkpoint molecules programmed cell death protein 1 (PD-1) cytotoxic T-lymphocyte associated 4 (CTLA-4) are a promising cancer treatment. In recent years, research on CD28 has increased. Although numerous reports involve its downstream PI3K/AKT/mTOR signaling mechanisms metabolism, they have not yet been elucidated. A literature search strategy was used for databases PubMed, Scopus, Web Science Cochrane Library to ensure broad coverage medical scientific literature, using combination keywords including, but limited to, 'lung cancer' 'immunotherapy'. Therefore, present study reviewed interaction clinical application PD-1/CTLA-4/CD28 pathways cells, aiming provide theoretical basis immunotherapy patients.

Language: Английский

Citations

5
Association between immune-related adverse events and prognosis in immune checkpoint inhibitor therapy: A bibliometric and visual analysis DOI Creative Commons
Jun Zhao, Xianghua Quan, Liang Yu

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 18, 2025

Language: Английский

Citations

0
Long-term survival in a patient with ruptured advanced hepatocellular carcinoma treated with nutritional therapy combined with apatinib and camrelizumab: a case report DOI Creative Commons

Yaohao Liang,

Tianyu Ruan,

Jiaqian He

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 23, 2025

Spontaneous rupture is a fatal complication of advanced hepatocellular carcinoma (HCC) with an extremely poor prognosis. Although immune checkpoint inhibitors, targeted therapies, and nutritional therapy have shown potential in the treatment HCC, their combined efficacy complex cases high tumor burden complicated by bleeding remains unclear. A 54-year-old male patient was diagnosed Barcelona Clinic Liver Cancer (BCLC) stage C HCC burden, accompanied history chronic hepatitis B moderate malnutrition. After initial apatinib (500 mg/day) therapy, experienced rupture. Following emergency transarterial embolization for hemostasis, regimen adjusted to camrelizumab (200 mg/2 weeks) reduced-dose (250 mg/day), along continued support. 17 months treatment, underwent hepatectomy, pathological examination showing complete remission left liver. Postoperative adjuvant included chemoembolization, individualized immunotherapy. As 4-year follow-up, patients has good quality life not recurrence. This case showcases multimodal strategy complications, integrating immuno-targeted interventional management providing possible approach achieving long-term survival. comprehensive method may offer new insights into improving prognosis HCC.

Language: Английский

Citations

0
Identification of prognostic signatures of ferroptosis and autophagy-dependent lipid metabolism-related genes in hepatocellular carcinoma DOI

Mei-Lv Liang,

Wenqing Liang, Qing Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract The regulatory role of ferroptosis and autophagy in lipid metabolism during hepatocellular carcinoma (HCC) progression remains largely unexplored. Through integrated analysis TCGA, MsigDB, FerrDb, HADb datasets, we identified 33 autophagy-dependent metabolism-related genes (Fer-Aut-LMRGs) with prognostic significance. A novel two-gene (TXNRD1 ALAS1) model was developed using Cox LASSO regression analyses validated the ICGC cohort. risk score emerged as an independent factor, effectively stratifying patients correlating immune microenvironment features, immunotherapy response, drug sensitivity. High-risk exhibited enhanced escape potential reduced response to checkpoint inhibition. Single-cell revealed dynamic evolution tumor cell populations HCC progression. Experimental validation confirmed expression patterns demonstrated ALAS1's functional regulating invasion migration. These findings establish a crucial link between ferroptosis, autophagy, HCC, providing robust tool therapeutic targets for personalized management. study highlights clinical relevance integrating multi-omics approaches cancer research.

Language: Английский

Citations

0
Role for Artificial Intelligence in the Detection of Immune-Related Adverse Events DOI
Mohamed I. Elsaid, Alexa Meara, Dwight H. Owen

et al.

Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Language: Английский

Citations

1
Risk and Benefit for Basket Trials in Oncology: A Systematic Review and Meta-Analysis DOI Creative Commons
Katarzyna Klaś, Karolina Strzebońska, Łucja Zaborowska

et al.

Targeted Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Oncology research is increasingly adopting new clinical trial models that implement the concept of precision medicine. One these basket design. Basket trials allow treatments to be evaluated across multiple tumor types. Patients recruited share certain molecular characteristics their cancer are predictive benefit from experimental treatment.

Language: Английский

Citations

0