Oral and Oropharyngeal Microbiome – Characteristics, Significance, and Potential Therapeutic Interventions DOI

Laura Ziuzia-Januszewska,

Jakub Zygało,

Eliza Brożek-Mądry

et al.

Polski Przegląd Otorynolaryngologiczny, Journal Year: 2024, Volume and Issue: 13(4), P. 19 - 30

Published: Dec. 19, 2024

The proper functioning of the human body largely depends on microorganisms it hosts. ecosystem formed by these microorganisms, along with their genome, metabolites they produce, and conditions in environment, constitutes microbiome. microbiome plays a crucial role regulating host’s physiological, immunological, metabolic functions. Changes composition can affect occurrence progression both local oral cavity oropharynx, as well systemic diseases. Therefore, is essential to explore methods for modifying microbiome’s preventing negative consequences dysbiosis. Current research focuses probiotics, prebiotics, dietary supplements, antibiotics, chemotherapeutics. This review aims summarize knowledge regarding oropharyngeal microbiome, its significance health, potential therapeutic approaches influence this complex ecosystem.

Language: Английский

Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review DOI Creative Commons
Myrto Papamentzelopoulou, Vassiliki Pitiriga

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 293 - 293

Published: March 18, 2025

The human microbiome plays a vital role in maintaining homeostasis, acting as key regulator of host immunity and defense mechanisms. However, dysbiotic microbial communities may cause disruption the symbiotic relationship between local microbiota, leading to pathogenesis various diseases, including viral infections cancers. One most common infectious agents causing cancer is papilloma virus (HPV), which accounts for more than 90% cervical In cases, immune system activated clears HPV, whereas some infection persists can lead precancerous lesions. Over last two decades, advent next-generation sequencing (NGS) technology bioinformatics has allowed thorough in-depth analysis composition anatomical niches, allowing researchers unveil interactions underlying mechanisms through microbiota could affect HPV establishment, persistence, progression. Accordingly, present narrative review aims shed light on our understanding context its progression, mainly cancer. Furthermore, we explore by balance exert potential pathogenic or protective effects, either persistence disease outcomes clearance. Special interest given how modulate infection. Lastly, summarize latest findings therapeutic efficacy probiotics prebiotics preventing and/or treating vaginal transplantation while highlighting significance personalized medicine approaches emerging from NGS-based profiling artificial intelligence (AI) optimal management HPV-related diseases.

Language: Английский

Citations

0
Investigation of Immune-Related Hub Genes as Prognostic Biomarkers in HPV-Positive Oropharyngeal Cancer DOI

Chin-Hsuan Yeh,

Tsung-Ming Chang,

Chia-Yu Wu

et al.

Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Human Papilloma Virus (HPV) Detection in Oral Rinse vs. Oral Sponge: A Preliminary Accuracy Report in Oral Cancer Patients DOI Open Access
Vera Panzarella, Michela Buttà, Fortunato Buttacavoli

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3256 - 3256

Published: Sept. 24, 2024

Background/Objectives: Human Papillomavirus (HPV) is a significant etiological factor in the development of oropharyngeal carcinogenesis. The detection HPV oral squamous cell carcinoma (OSCC) could be also crucial for diagnosis, prognosis, and treatment planning. This study compares efficacy accuracy two non-invasive sampling methods, rinse, sponge, detecting DNA patients with OSCC. Methods: Twenty-six histologically confirmed OSCCs were recruited (M/F = 15/11; mean age 68.6). From each patient, self-collected specimens, form an rinse salivary sponge (i.e., LolliSponge), collected, subsequently processed, utilizing INNO-LiPA Genotyping Extra II detection; Results: Oral showed high specificity (100%), sensitivity (85.7%), (96.2%) compared to sampling, demonstrating area AUC its diagnostic performance significantly greater than 0.5 (0.93 vs. 0.5, p < 0.0001). Conclusions: supports that offers valuable alternatives OSCC, potentiality facilitate saliva may exhibit functional deficit due Further research recommended validate these findings larger cohorts explore integration methods into routine clinical practice management HPV-related

Language: Английский

Citations

1
Oral and Oropharyngeal Microbiome – Characteristics, Significance, and Potential Therapeutic Interventions DOI

Laura Ziuzia-Januszewska,

Jakub Zygało,

Eliza Brożek-Mądry

et al.

Polski Przegląd Otorynolaryngologiczny, Journal Year: 2024, Volume and Issue: 13(4), P. 19 - 30

Published: Dec. 19, 2024

The proper functioning of the human body largely depends on microorganisms it hosts. ecosystem formed by these microorganisms, along with their genome, metabolites they produce, and conditions in environment, constitutes microbiome. microbiome plays a crucial role regulating host’s physiological, immunological, metabolic functions. Changes composition can affect occurrence progression both local oral cavity oropharynx, as well systemic diseases. Therefore, is essential to explore methods for modifying microbiome’s preventing negative consequences dysbiosis. Current research focuses probiotics, prebiotics, dietary supplements, antibiotics, chemotherapeutics. This review aims summarize knowledge regarding oropharyngeal microbiome, its significance health, potential therapeutic approaches influence this complex ecosystem.

Language: Английский

Citations

0