The
prevalence
of
autism
spectrum
disorder
(ASD)
is
increasing
worldwide.
Youngsters
with
ASD
demonstrate
higher
rates
intellectual
disabilities
(IDs),
comorbid
psychopathology
and
psychiatric
hospitalizations,
compared
to
children
in
the
general
population.
This
study
characterizes
demographics
clinical
parameters
adolescent
inpatients
without
ASD,
all
hospitalized
during
period.
Additionally,
within
group,
those
ID
were
without.
rate
males
among
participants
was
significantly
than
duration
hospitalization
longer.
In
contrast,
cigarette
smoking,
major
depressive
suicidal
thoughts
lower.
One-third
had
moderate
severe
ID,
about
10%
epilepsy,
half
them
demonstrated
aggressive
behavior.
Most
patients
showed
significant
improvement
upon
discharge,
although
extent
more
prominent
no
ID.
Our
findings,
consistent
previous
research,
indicate
that
beneficial
youths
both
Further
studies
include
long-term
follow-up
are
needed.
Current Neuropharmacology,
Journal Year:
2023,
Volume and Issue:
22(2), P. 260 - 289
Published: Oct. 17, 2023
Autism
Spectrum
Disorder
(ASD)
is
a
neurodevelopmental
disorder
with
increased
prevalence
and
incidence
in
recent
decades.
Its
etiology
remains
largely
unclear,
but
it
seems
to
involve
strong
genetic
component
environmental
factors
that,
turn,
induce
epigenetic
changes
during
embryonic
postnatal
brain
development.
In
decades,
clinical
studies
have
shown
that
inutero
exposure
valproic
acid
(VPA),
commonly
prescribed
antiepileptic
drug,
an
factor
associated
risk
of
ASD.
Subsequently,
prenatal
VPA
rodents
has
been
established
as
reliable
translational
model
study
the
pathophysiology
ASD,
which
helped
demonstrate
neurobiological
rodents,
non-human
primates,
organoids
from
human
pluripotent
stem
cells.
This
evidence
supports
notion
valid
current
replicate
idiopathic
ASD-like
experimental
animals.
review
summarizes
describes
features
reported
this
animal
autism
main
findings
correlates
help
elucidate
Finally,
we
discuss
general
framework
comparison
other
ASD
models.
Behavioral Sciences,
Journal Year:
2024,
Volume and Issue:
14(1), P. 46 - 46
Published: Jan. 10, 2024
Mothers
of
children
with
autism
spectrum
disorder
(ASD)
face
considerable
psychological
distress.
Cognitive
behavioral
therapy
(CBT)
has
shown
promise
in
reducing
caregiver
burden,
but
evidence
the
Arab
world
is
lacking.
Problem-solving
appraisal
training
may
optimize
CBT's
benefits.
This
study
evaluated
a
tailored
CBT
program
emphasizing
role
problem-solving
managing
distress
through
process
CBT.
Sixty
mothers
were
randomly
allocated
1:1
ratio
to
either
intervention
group
or
control
group.
The
received
3-month
sessions
incorporating
within
curriculum
from
October
2022
April
2023.
techniques
are
focused
on
equipping
individuals
skills
identify,
approach,
and
effectively
resolve
problems,
leading
reduction
stress
levels
an
improved
capacity
cope
difficult
situations.
All
completed
assessments
socio-demographics
such
as
age,
level
education,
marital
status,
occupation,
adequacy
family
income,
Depression
Anxiety
Stress
Scale
(DASS-21)
Problem-Solving
Inventory
(PSI)
before
after
program.
showed
significant
pre-to-post
reductions
depression,
anxiety,
stress,
general
compared
controls
(all
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 9, 2023
Exposure
to
endocrine-disrupting
chemicals
(EDCs)
during
critical
neurodevelopmental
windows
has
been
associated
with
the
risk
of
autistic
traits.
This
systematic
review
epidemiological
studies
examined
association
between
maternal
exposure
EDCs
pregnancy
and
autism
spectrum
disorder
(ASD)
in
offspring.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14898 - 14898
Published: Oct. 4, 2023
Neurological
diseases,
including
neurodegenerative
and
neurodevelopmental
disorders,
affect
nearly
one
in
six
of
the
world’s
population.
The
burden
resulting
deaths
disability
is
set
to
rise
during
next
few
decades
as
a
consequence
an
aging
To
address
this,
zebrafish
have
become
increasingly
prominent
model
for
studying
human
neurological
diseases
exploring
potential
therapies.
Zebrafish
offer
numerous
benefits,
such
genetic
homology
brain
similarities,
complementing
traditional
mammalian
models
serving
valuable
tool
screening
drug
discovery.
In
this
comprehensive
review,
we
highlight
various
delivery
techniques
systems
employed
therapeutic
interventions
zebrafish,
evaluate
their
suitability.
We
also
discuss
challenges
encountered
process
present
advancements
innovative
techniques.
Journal of Autism and Developmental Disorders,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
There
is
a
gap
in
autism
research
from
Low-
and
Middle-Income
Countries
(LMIC)
where
most
children
with
live.
This
has
contributed
to
lack
of
culturally
validated
diagnostic
instruments
for
major
barrier
early
diagnosis,
intervention,
research.
The
Arabic
Language
Autism
Diagnostic
Inventory
(ALADIN)
was
developed
based
on
the
DSM-5
criteria
adapted
language
culture
using
primary
source
data.
aim
this
study
validate
evaluation
autism.
A
case–control
design
used
test
instrument
sensitivity
specificity
diagnosis
2–5
years
age.
Parents
48
152
neurotypical
Jordan
completed
ALADIN.
Demographic
information
participants
each
group
summarized,
Receiver
Operating
Curve
(ROC)
fit
total
score
24
ALADIN
had
77%
98%
area
under
curve
(AUC)
0.976,
indicating
strong
performance
identifying
first
created
specifically
Arab
populations
informed
by
cultural
linguistic
data
target
population.
Initial
validation
shows
it
high
Culturally
can
improve
access
intervention
enhance
care
outcomes
global
populations.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(4), P. 213 - 213
Published: March 21, 2025
Background/Objectives:
Currently,
the
diagnosis
of
autism
spectrum
disorder
(ASD)
relies
on
behavioral
observations,
frequently
causing
delays
in
early
identification.
Prognostic
markers
are
essential
for
customizing
therapy
and
monitoring
progress.
However,
there
currently
no
recognized
biomarkers
ASD.
The
current
systematic
review
aims
to
analyze
studies
intestinal
metabolome
children
(both
autistic
non-autistic)
identify
potential
metabolites
diagnostic
prognostic
purposes.
Methods:
We
searched
Medline,
Scopus,
Embase,
Web
Science
relevant
publications.
Results:
identified
11
examining
gut
that
distinguished
between
non-autistic
children.
These
also
revealed
connections
metabolites,
developmental
scores,
symptoms.
substances
were
associated
with
metabolic
pathways
such
as
amino
acids,
vitamins,
lipids,
oxidative
stress,
glycans,
xenobiotics,
nucleotides.
Conclusions:
findings
suggest
changes
may
be
linked
causes
or
development
autism.
Although
these
observations
came
from
a
few
reports,
only
high-quality
included
this
review.
Further
research
is
confirm
biomarkers.
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: March 8, 2023
Autistic
men
and
women
are
more
likely
to
experience
health
issues
than
the
general
population,
although
available
epidemiological
studies
addressing
co-occurrence
conditions
limited.
This
is
first
Spanish
epidemiologic
study
profile
poor-health
exacerbating
factors
in
individuals
of
all
ages
with
autism
spectrum
disorder
(ASD).We
analyzed
2,629
registries
extracted
from
Autism
Spain's
sociodemographic
registry
(November
2017-May
2020).
A
descriptive
data
analysis
was
conducted
assess
prevalence
other
associated
ASD
population.
Nervous
system
disorders
(12.9%),
mental
diagnoses
(17.8%),
comorbidities
(25.4%)
were
reported.
Men-to-women
ratio
4:1.Women,
elder
those
intellectual
disability
(ID)
at
an
increased
risk
psychopharmacological
exposure.
Women
also
prone
severe
functional
impairment.
Nearly
had
difficulties
their
adaptative
functioning,
especially
ID
(50%
population).
Almost
half
sample
received
treatments
starting
infancy
early
childhood,
mostly
antipsychotics
anticonvulsants.This
represents
important
approach
status
autistic
people
Spain
can
contribute
development
public
policies
innovative
strategies.
