Impact of short and intensive art-based intervention on symptomatology and social interactions among children with autism spectrum disorder

Clinical and Experimental Pediatrics, Journal Year: 2023, Volume and Issue: 66(10), P. 447 - 454

Published: Sept. 14, 2023

Consensus on the effectiveness of art therapy in children with autism spectrum disorders (ASDs) is lacking literature.Here, we examined a short and intensive art-based intervention autistic symptomatology social skills among ASD levels 2 3.This pre- postexperimental investigation included 13 previously diagnosed 3 Kurdistan Region 2019. They completed hours/day for days/week 1 month. The activities cutting pasting squares triangles, coloring black-and-white images, recognizing shapes. Children used wooden aquatic pens scissors under guidance. Symptom severity was measured using Social Responsiveness Scale (SRS-2), validated tool measuring traits symptoms that features subscales awareness, cognition, communication, motivation, mannerisms. level require significant support experience notable difficulties verbal while those extensive have most severe form autism. outcome one day before course commenced week after completion.The mean patient age (n=13) 8.15 years (standard deviation, 1.95; range, 5-11 years). Most patients were male (n=11, 84.62%). SRS-2 score did not change significantly to postexperiment (159 vs. 157, P=0.601). Similarly, found no changes awareness (19 19, P=0.779); cognition (28 27, P=0.199); communication (56 54, P=0.600); motivation (26 24, P=0.684); mannerisms (33 32; P= 0.780), respectively.The improve or interactions 3.

Language: Английский

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The therapeutic effects of probiotics on core and associated behavioral symptoms of autism spectrum disorders: a systematic review and meta-analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

Abstract Background The current study aimed at investigating the efficacies of probiotics in alleviating core and associated symptoms autism spectrum disorder (ASD), which was not adequately addressed literature. Methods Randomized placebo-controlled trials were identified through searching major electronic databases from inception to Nov 2023. outcome interests included improvements total ASD. Outcomes quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95% confidence interval (CI). Results Ten studies 522 participants (mean age: 8.11) this meta-analysis. primary results revealed a significant improvement ASD individuals receiving compared controls (SMD= -0.19, p = 0.03, ten participants) but including repetitive restricted behaviors problems social or communication. Subgroup analyses demonstrated an association between use relative their only that used multiple-strain -0.26, five 288 those using single-strain probiotics. Our secondary outcomes showed significantly greater adaptation (SMD 0.37, three 139 trend anxiety group than control -0.29, CI: -0.60 0.02, 0.07, 163 failed show regarding irritability/aggression, hyperactivity/impulsivity, inattention parental stress. Conclusions supported for overall behavioral ASD, mainly supplements. However, rather perhaps anxiety. Nevertheless, our results, derived limited number available trials, warrant further large-scale clinical investigations verification.

Language: Английский

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An exploration of structural brain differences in Autism Spectrum Disorders: A multi-parcellation and multi-age analysis

Biomedical Signal Processing and Control, Journal Year: 2024, Volume and Issue: 92, P. 106043 - 106043

Published: Feb. 21, 2024

Language: Английский

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Análise da prevalência do Transtorno do Espectro Autista em crianças nos últimos 10 anos

Revista Eletrônica Acervo Saúde, Journal Year: 2024, Volume and Issue: 24(6), P. e15551 - e15551

Published: June 20, 2024

Objetivo: Analisar os dados epidemiológicos disponíveis na literatura científica entre anos de 2013 e 2023, visando compreender o possível aumento da prevalência do Transtorno Espectro Autista (TEA). Revisão bibliográfica: O autismo é um transtorno caracterizado pelo prejuízo interação social, dificuldade comunicação comportamento repetitivo, apresentando diferentes necessidades níveis suporte. Com a leitura dos artigos selecionados, foi construído uma linha raciocínio, buscando compreendendo sua etiologia, sintomatologia diagnóstico. Visto isso, com decorrer estudos foram encontrados números que confirmam no âmbito mundial, entretanto ainda há dúvidas acerca causa, autores conflitam exposição fatores risco, limitação nas pesquisas, falta padrão diagnóstico, outros motivos possam explicar crescente demanda clínica autismo. Considerações finais: Pode se considerar são necessários mais área, para quais as regiões populações maior variáveis levam ao diagnóstico TEA.

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Understanding heterogeneity within autism spectrum disorder: a scoping review

Advances in Autism, Journal Year: 2024, Volume and Issue: 10(4), P. 314 - 322

Published: Aug. 19, 2024

Purpose In this study, the research question posed was: What are defining characteristics, limitations, and potential opportunities in on heterogeneity within ASD? Design/methodology/approach This scoping review used Preferred Reporting Items for Systematic Reviews Meta-Analyses methodology to address question: “What ASD?” A comprehensive literature search was conducted across databases including MEDLINE/PubMed, SciVerse Scopus Springer Link, with keywords such as autism, autism spectrum disorder (ASD), neurodevelopment. Inclusion criteria covered original research, reviews protocols published since 1990, while irrelevant or out-of-date works were excluded. Thematic analysis applied collected data identify common patterns, trends key leading a narrative synthesis. Ethical board approval not required due nature of review. Findings The underscored multifaceted ASD, emphasizing its clinical, methodological investigational complexities. ASD’s diverse behavioral, social biological characteristics challenged classification uniform entity. To this, examined strategies like stricter clinical criteria, categorization into functional subgroups, larger, sample sizes. Moreover, it highlighted transformative role Big Data machine learning advancing comprehension manifold manifestations. contributed valuable insights innovative approaches addressing intrinsic reshaping understanding complex condition. Research limitations/implications One limitation is that primarily relied existing did involve primary collection. While synthesized analyzed substantial body absence collection may limit depth specific aspects ASD heterogeneity. Future could benefit from incorporating methods, surveys interviews individuals their families, gain more nuanced perspectives condition’s Practical implications reliance highlights need further empirical studies exploring Researchers should consider conducting capture real-world experiences variations population. approach provide context-specific insights, ultimately informing development tailored interventions support families. Originality/value paper offers fresh perspective by examining light inherent Rather than viewing condition, study explores subcategorization based functionality sizes complexity. addition, use deeper contributes new promising directions future challenging conventional singular

Language: Английский

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Harnessing Virtual Reality: Improving Social Skills in Adults with Autism Spectrum Disorder

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6435 - 6435

Published: Oct. 27, 2024

Background and Objectives: Autism Spectrum Disorder (ASD) involves challenges in social communication daily functioning. Emerging research highlights that virtual reality (VR) interventions can significantly improve skills adults with ASD by providing immersive, controlled practice environments. This systematic review will assess the effectiveness of VR-based for improving ASD. Materials Methods: Studies were identified from an online search PubMed, Web Science, Cochrane Library, Embase databases without any time range. was registered on Open OSF (n) P4SM5. Results: Recent studies show VR enhance job interview skills, abilities, practical tasks ASD, improvements confidence, understanding, everyday skills. has been shown to be user-friendly effective adaptable training experiences. Conclusions: The VR’s promising role functioning It emphasizes need broader studies, standardized interventions, exploration integration other therapies long-term address comorbidities like anxiety depression.

Language: Английский

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Beyond Metabolic Messengers: Bile Acids and TGR5 as Pharmacotherapeutic Intervention for Psychiatric Disorders

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107564 - 107564

Published: Dec. 1, 2024

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed current treatments. This review explores emerging role of bile acids TGR5 receptor in pathophysiology psychiatric conditions, emphasizing their signaling within gut-brain axis. We detail synthesis systemic functions acids, transformation gut microbiota, impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety schizophrenia, autism spectrum bipolar disorder. The highlights how dysbiosis altered acid metabolism contribute to development exacerbation these through mechanisms involving inflammation, oxidative stress, neurotransmitter dysregulation. Importantly, we both pharmacological non-pharmacological interventions that modulate signaling, offering potential breakthroughs treatment strategies. These include dietary adjustments enhance beneficial production use specific agonists have shown promise preclinical clinical settings for regulatory effects on critical pathways such as cAMP-PKA, NRF2-mediated antioxidant responses, neuroinflammation. By integrating findings from dynamics metabolism, related events, this underscores cutting-edge therapeutic approaches poised revolutionize management disorders.

Language: Английский

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Global burden and inequality of autism spectrum disorders: Based on data from the 2019 Global Burden of Disease study

Preventive Medicine Reports, Journal Year: 2023, Volume and Issue: 36, P. 102511 - 102511

Published: Nov. 11, 2023

It is unclear whether the health equity of autism spectrum disorders (ASDs) has changed in different years, regions, and gender. The aims this study were to provide a comprehensive description ASDs burden evidence for improvement policies regarding inequality. This population-based cross-sectional based on Global Burden Disease datasets 1990-2019. We collected detailed information between 1990 2019 204 countries worldwide, derived from 2019. was calculated terms incidence, prevalence years lived with disability (YLDs). Concentration curves concentration indices used summarize degree income-related inequality ASDs. overall age-standardized incidence rate (ASIR), (ASPR) YLDs (ASYR) 9.3 (95 %UI 7.7-11.1), 369.4 305.9-441.2), 56.3 36.8-81.5) per 100,000 people, respectively. ASIR, ASPR ASYR affected three times as many males females. changing trends rates showed that ASIR slow growing trend globally. However, decreasing All below line equality statistically significant. There no significant difference socio-demographic index-related happened over 29 (p > 0.05). global remained higher pro-rich, tended not change

Language: Английский

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Sleep problems in children with autism spectrum disorder in Hong Kong: a cross-sectional study

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: April 17, 2023

Background Autism spectrum disorder (ASD) is a neurodevelopmental with growing prevalence of sleep problems associated significant behavioral and more severe autism clinical presentation. Little known about the relationships between traits in Hong Kong. Therefore, this study aimed to examine whether children have increased than non-autistic The secondary objective was factors an sample. Methods This cross-sectional recruited 135 102 same age range children, aged 6 12 years. Both groups were screened compared on their behaviors using Children's Sleep Habits Questionnaire (CSHQ). Results Children had significantly [ t (226.73) = 6.20, p < 0.001]. Bed -sharing [beta 0.25, (165) 2.75, 0.07] maternal at birth 0.15, 2.05, 0.043] CSHQ score top traits. Stepwise linear regression modeling identified that only separation anxiety ( beta 4.83, 2.40, 0.019) best-predicted CSHQ. Conclusion In summary, autistic suffered from co-occurring brings greater as children. Clinicians should be aware provide effective treatments autism.

Language: Английский

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[Association between maternal gestational diabetes mellitus and the risk of autism spectrum disorder in offspring].

PubMed, Journal Year: 2023, Volume and Issue: 25(8), P. 818 - 823

Published: Aug. 15, 2023

To explore the association between maternal gestational diabetes mellitus (GDM) exposure and development of autism spectrum disorder (ASD) in offspring.A case-control study was conducted, recruiting 221 children with ASD 400 healthy as controls. Questionnaires interviews were used to collect information on general characteristics children, socio-economic family, pregnancy history, disease during pregnancy. Multivariate logistic regression analysis investigate GDM offspring. The potential interaction offspring gender explored.The proportion significantly higher group compared control (16.3% vs 9.4%, P=0.014). After adjusting for variables such gender, age, mode delivery, parity, education level, a risk factor (OR=2.18, 95%CI: 1.04-4.54, P=0.038). On basis above variables, after further including prenatal intake multivitamins, folic acid first three months pregnancy, assisted reproduction result trend did not change, but no statistical significance observed (OR=1.94, 0.74-5.11, P=0.183). There an (P<0.001). Gender stratified showed that only male mothers GDM, increased (OR=3.67, 1.16-11.65, P=0.027).Maternal might increase is offspring.目的: 探讨母亲妊娠糖尿病暴露与子代孤独症谱系障碍（autism disorder，ASD）发生的关联。方法: 采用病例对照研究方法，招募221例ASD儿童与400例健康儿童纳入研究。采用问卷调查及访谈形式收集儿童一般情况、家庭社会经济学特征、母亲孕产史、母亲孕期疾病暴露等情况，采用多因素logistic回归分析探讨母亲妊娠糖尿病暴露与子代ASD发生的关联，并探讨子代性别和妊娠糖尿病暴露对子代ASD的发生是否存在交互作用。结果: ASD组母亲妊娠糖尿病患病比例显著高于对照组（16.3% 9.4%，P=0.014）。校正性别、胎龄情况、出生方式、产次、母亲文化程度等变量后，母亲妊娠糖尿病暴露是子代ASD发生的危险因素（OR=2.18，95%CI：1.04~4.54，P=0.038）；在校正以上变量的基础上，进一步校正孕早期复合维生素服用、孕前3个月叶酸服用和辅助生殖等变量后，结果趋势未发生改变，但未见统计学意义（OR=1.94，95%CI：0.74~5.11，P=0.183）。妊娠糖尿病暴露与子代性别对子代ASD的发生存在交互作用（P<0.001）；性别分层分析显示，仅在妊娠糖尿病母亲的男性子代中ASD发病风险显著增加（OR=3.67，95%CI：1.16~11.65，P=0.027）。结论: 母亲妊娠糖尿病暴露可能增加子代ASD的发生风险；妊娠糖尿病暴露和子代性别对子代ASD的发生存在交互作用。.

Language: Английский

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