Rates of Positive M-CHAT-R Screenings by Pandemic Birth and Prenatal SARS-CoV-2 Exposure DOI
Morgan R. Firestein, Angela Gigliotti Manessis, Jennifer M. Warmingham

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Abstract Maternal stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Children born the COVID-19 pandemic, including those exposed prenatally to maternal SARS-CoV-2 infections, reaching developmental age for assessment of risk conditions. We examined associations between birth prenatal exposure infection, rates positive screenings on Modified Checklist Autism Toddlers-Revised (M-CHAT-R). Data were drawn from Mother Baby Outcomes (COMBO) Initiative. Participants completed M-CHAT-R as part routine clinical care (COMBO-EHR cohort) or research purposes (COMBO-RSCH cohort). status was determined through electronic health records. The COMBO-EHR cohort includes n=1664 children (n=442 historical cohort, n=1222 pandemic cohort; n=997 unexposed prenatally, n=130 prenatally) who at affiliated hospitals 2018-2023 had a valid score their record. COMBO-RSCH consists n=359 (n=268 n=91 same enrolled into prospective study that included administration 18-months. Birth not greater likelihood screen cohort. lower screening adjusted models (OR=0.40, 95% CI=0.22 - 0.68, p =0.001), while analyses yielded similar but non-significant results (OR=0.67, CI=0.31-1.37, =0.29).These suggest first 18 months infection M-CHAT-R.

Language: Английский

Maternal-fetal cytokine profiles in acute SARS-CoV-2 “breakthrough” infection after COVID-19 vaccination DOI Creative Commons
Claire H. Packer,

Olyvia Jasset,

Nikolina Hanniford

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Vaccination is protective against severe COVID-19 disease, yet whether vaccination reduces COVID-19-associated inflammation in pregnancy has not been established. The objective of this study to characterize maternal and cord cytokine profiles acute SARS-CoV-2 "breakthrough" infection (BTI) after vaccination, compared with unvaccinated uninfected controls. 66 pregnant individuals enrolled the MGH biorepository (March 2020-April 2022) were included. Maternal sera collected from 26 21 vaccinated infection. Cord at delivery. 19 term dyads without current or prior analyzed as Cytokines quantified using Human Inflammation 20-Plex ProcartaPlex assay. There was a significantly higher incidence severe/critical illness (10/26 (38%) vs. 0/21 (0%), p<0.01). Significantly levels TNFα CD62P observed BTI (p<0.05). Network correlation analyses revealed distinct response vs individuals. Neither nor resulted elevated cytokines Multivariate demonstrate setting associated during infection, which may reflect vaccine-mediated priming immune system. A fetal inflammatory specific observed.

Language: Английский

Citations

0
From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment DOI
Daniele Mattei, Dilansu Güneykaya, Bilge Ugursu

et al.

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 269 - 285

Published: Jan. 1, 2025

Language: Английский

Citations

0
SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort DOI Creative Commons
Frederieke Gigase, Rebecca H. Jessel, Elianna Kaplowitz

et al.

Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 163, P. 104243 - 104243

Published: March 18, 2024

Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting the role of immune system is currently unclear. This prospective cohort study investigated interaction infection, changes in cytokine HS-CRP levels, birthweight gestational age at birth. 2,352 pregnant participants from New York City (2020-2022) were included. Plasma levels interleukin (IL)-1β, IL-6, IL-17A high-sensitivity C-reactive protein (HS-CRP) quantified blood specimens obtained across pregnancy. Quantile linear regression models conducted to 1) assess impact overall by timing detection positivity (< 20 weeks versus ≥ weeks), on delivery; 2) examine relationship maternal during All adjusted for demographic obstetric factors pandemic timing. Birthweight additionally delivery fetal sex. Immune marker also specimen collection multiplex assay batch. 371 (15.8%) infected with pregnancy, which 98 (26.4%) < gestation. Neither general nor early or late was associated lower earlier delivery. Further, we did not observe response thus found no evidence support a potential association dysregulation diversity following infection.

Language: Английский

Citations

3
Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis DOI Creative Commons
Samhita Jain, Isabel Elaine Allen, Dongli Song

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 17, 2023

Background The COVID-19 pandemic has affected a significant number of pregnant women worldwide, but studies on immune responses have presented conflicting results. This study aims to systematically review cytokine profiles in with SARS-CoV-2 infection and their infants evaluate potential transplacental transfer cytokines. Materials methods A comprehensive search 4 databases was conducted identify relevant studies. Inclusion criteria included measuring individual cytokines and/or neonates. Studies were evaluated for quality, data extracted analysis. Meta-analyses performed using the random-effects model. Results Seventeen met inclusion criteria, including from 748 287 infants. More than three these 20 maternal serum, 10 available cord blood samples. Only serum level CXCL10 significantly up-regulated positive ( n = 339) compared negative 409). Subset analysis samples 183) collected during acute phase showed elevated IFN-γ. No differences levels found between born mothers 97) without 190) gestation. limited by insufficient data. heterogeneity among substantial. Conclusion findings suggest that pregnancy are not dysregulated, except IFN-γ illness. evidence increased observed, although this could be impacted time period initial collection. These results provide some reassurance parents healthcare providers should interpreted cautiously due variations limitations.

Language: Английский

Citations

7
Maternal immunity shapes biomarkers of germinal center development in HIV‐exposed uninfected infants DOI Creative Commons
Li Yin,

Guglielmo M. Venturi,

Richard Barfield

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 12, 2024

HIV-exposed uninfected (HEU) infants exhibit elevated pro-inflammatory biomarkers that persist after birth. However, comprehensive assessments of bioprofiles associated with immune regulation and development in pregnant women HIV (PWH) HEU has not been performed. Maternal immunity PWH may be imprinted on their newborns, altering during early development.

Language: Английский

Citations

2
Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic DOI Creative Commons
Morgan R. Firestein, Angela Gigliotti Manessis, Jennifer M. Warmingham

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(9), P. e2435005 - e2435005

Published: Sept. 23, 2024

Importance Stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Autism screening positivity for children born the pandemic remains unknown. Objective To examine associations between prenatal exposure to milieu maternal SARS-CoV-2 infection rates of positive Modified Checklist Toddlers, Revised (M-CHAT-R) screenings. Design, Setting, Participants Data this cohort study were drawn from COVID-19 Mother Baby Outcomes (COMBO) Initiative. M-CHAT-R scores obtained aged 16 30 months routine clinical care at Columbia University Irving Medical Center New York City abstracted electronic health records (EHRs) January 2018 September 2021 (COMBO-EHR cohort). Separately, was administered 18 February 2020 through a prospective longitudinal (COMBO-RSCH Prenatal (birth after March 1, 2020) status determined EHRs. analyzed 2022 June 2024. Exposures exposures infection. Main Measures The primary outcome rate For all analyses, unadjusted χ 2 tests adjusted logistic regression models performed. Results COMBO-EHR included 1664 (442 before 1222 pandemic; 997 unexposed, 130 exposed, 95 unknown status), whom 266 (16.0%) Black, 991 (59.6%) Hispanic, 400 (24.0%) White, 1245 (74.8%) insured Medicaid, 880 (52.9%) male, 204 (12.3%) prematurely. COMBO-RSCH 385 (74 311 201 101 9 39 (10.1%) 168 (43.6%) 157 (40.8%) 161 (41.8%) 222 (57.7%) 38 (9.9%) not higher either or cohort. lower (12.3% [16 children] vs 24.0% [239 children]; odds ratio, 0.40; 95% CI, 0.22-0.68; P = .001), but no association found (12.9% [13 19.9% [40 0.51; 0.24-1.04; .07). Conclusions Relevance In groups and/or infection, neither greater positivity.

Language: Английский

Citations

1
Rates of Positive M-CHAT-R Screenings by Pandemic Birth and Prenatal SARS-CoV-2 Exposure DOI
Morgan R. Firestein, Angela Gigliotti Manessis, Jennifer M. Warmingham

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Abstract Maternal stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Children born the COVID-19 pandemic, including those exposed prenatally to maternal SARS-CoV-2 infections, reaching developmental age for assessment of risk conditions. We examined associations between birth prenatal exposure infection, rates positive screenings on Modified Checklist Autism Toddlers-Revised (M-CHAT-R). Data were drawn from Mother Baby Outcomes (COMBO) Initiative. Participants completed M-CHAT-R as part routine clinical care (COMBO-EHR cohort) or research purposes (COMBO-RSCH cohort). status was determined through electronic health records. The COMBO-EHR cohort includes n=1664 children (n=442 historical cohort, n=1222 pandemic cohort; n=997 unexposed prenatally, n=130 prenatally) who at affiliated hospitals 2018-2023 had a valid score their record. COMBO-RSCH consists n=359 (n=268 n=91 same enrolled into prospective study that included administration 18-months. Birth not greater likelihood screen cohort. lower screening adjusted models (OR=0.40, 95% CI=0.22 - 0.68, p =0.001), while analyses yielded similar but non-significant results (OR=0.67, CI=0.31-1.37, =0.29).These suggest first 18 months infection M-CHAT-R.

Language: Английский

Citations

0