The Molecular Clock and Neurodegenerative Disease: A Stressful Time DOI Creative Commons

Bethany Carter,

Hannah Justin,

Danielle Gulick

et al.

Frontiers in Molecular Biosciences, Journal Year: 2021, Volume and Issue: 8

Published: March 26, 2021

Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This manifests as sleep cycle mistiming, alterations body temperature rhythms, an increase symptomatology during the early evening hours known Sundown Syndrome. Disruption of circadian homeostasis has also been implicated etiology disease. Indeed, individuals exposed to a shifting schedule activity, such health care workers, are at higher risk. Thus, bidirectional relationship exists between system neurodegeneration. At heart this crosstalk is molecular clock, which functions regulate homeostasis. Over past decade, connection become focal point investigation clock offers attractive target combat disease pathogenesis dysfunction, pivotal role for neuroinflammation stress established. review summarizes contributions etiology, well mechanisms by diseases affect clock.

Language: Английский

Acrylamide aggravates cognitive deficits at night period via the gut–brain axis by reprogramming the brain circadian clock DOI
Xintong Tan, Jin Ye, Weiqi Liu

et al.

Archives of Toxicology, Journal Year: 2018, Volume and Issue: 93(2), P. 467 - 486

Published: Oct. 29, 2018

Language: Английский

Citations

52
Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target? DOI Creative Commons
Chao Song, Jia Wang,

Brett Kim

et al.

BioMed Research International, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 11

Published: Sept. 27, 2018

Numerous physiological processes of mammals, including bone metabolism, are regulated by the circadian clock system, which consists a central regulator, suprachiasmatic nucleus (SCN), and peripheral oscillators BMAL1/CLOCK-PERs/CRYs system. Various turnover markers metabolism-regulating hormones such as melatonin parathyroid hormone (PTH) display diurnal rhythmicity. According to previous research, disruption due shift work, sleep restriction, or gene knockout is associated with osteoporosis other abnormal showing importance system for maintaining homeostasis metabolism. Moreover, common causes osteoporosis, postmenopausal status aging, changes in clock. In our we found that agonism regulators REV-ERBs inhibits osteoclast differentiation ameliorates ovariectomy-induced loss mice, suggesting genes may be promising intervention targets interventions at different time points can provide varying degrees protection, accounting rhythms optimal curative effects clinical treatment osteoporosis. this review, summarize current knowledge about

Language: Английский

Citations

49
Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms DOI
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin

et al.

NeuroMolecular Medicine, Journal Year: 2018, Volume and Issue: 20(2), P. 174 - 204

Published: March 23, 2018

Language: Английский

Citations

47
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease DOI Creative Commons
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin

et al.

Cells, Journal Year: 2020, Volume and Issue: 9(2), P. 314 - 314

Published: Jan. 28, 2020

Parkinson’s disease (PD) is one of the main neurodegenerative characterized by a progressive degeneration neurons constituted dopamine in substantia nigra pars compacta. The etiologies PD remain unclear. Aging risk factor for PD. could dysregulate molecular pathways controlling cell homeostatic mechanisms. cells are sites several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures driven circadian rhythms. Biologic rhythms complex systems interacting with environment physiological pathways. Recent findings have shown that dysregulation correlated its dysregulations. This review focused on key role their impact stress disease.

Language: Английский

Citations

41
The Molecular Clock and Neurodegenerative Disease: A Stressful Time DOI Creative Commons

Bethany Carter,

Hannah Justin,

Danielle Gulick

et al.

Frontiers in Molecular Biosciences, Journal Year: 2021, Volume and Issue: 8

Published: March 26, 2021

Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This manifests as sleep cycle mistiming, alterations body temperature rhythms, an increase symptomatology during the early evening hours known Sundown Syndrome. Disruption of circadian homeostasis has also been implicated etiology disease. Indeed, individuals exposed to a shifting schedule activity, such health care workers, are at higher risk. Thus, bidirectional relationship exists between system neurodegeneration. At heart this crosstalk is molecular clock, which functions regulate homeostasis. Over past decade, connection become focal point investigation clock offers attractive target combat disease pathogenesis dysfunction, pivotal role for neuroinflammation stress established. review summarizes contributions etiology, well mechanisms by diseases affect clock.

Language: Английский

Citations

34