Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 543 - 543

Published: Feb. 28, 2022

Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease preparation, as well large variety structural properties, liposomes have been employed in a nanomedicine biomedical applications, including nanocarriers for drug delivery, nutraceutical fields, immunoassays, clinical diagnostics, tissue engineering, theranostics formulations. Particularly important is the role drug-delivery they improve performance encapsulated drugs, reducing side effects toxicity enhancing its vitro- vivo-controlled delivery activity. These applications stimulated great effort scale-up formation processes view suitable industrial development. Despite improvements conventional approaches development novel routes liposome intrinsic sensitivity mechanical actions responsible some critical issues connected with limited colloidal stability reduced entrapment efficiency cargo molecules. This article analyzes main features fabrication techniques nanocarriers, special focus on structure, parameters, factors that influence stable formulation. Recent developments new methods preparation also discussed, objective updating reader providing future directions research

Language: Английский

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Analytical characterization of liposomes and other lipid nanoparticles for drug delivery

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2020, Volume and Issue: 192, P. 113642 - 113642

Published: Sept. 19, 2020

Language: Английский

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Engineered algae: A novel oxygen-generating system for effective treatment of hypoxic cancer

Science Advances, Journal Year: 2020, Volume and Issue: 6(21)

Published: May 20, 2020

Microalgae, a naturally present unicellular microorganism, can undergo light photosynthesis and have been used in biofuels, nutrition, etc. Here, we report that engineered live microalgae be delivered to hypoxic tumor regions increase local oxygen levels resensitize resistant cancer cells both radio- phototherapies. We demonstrate the environment tumors is markedly improved by situ-generated through microalgae-mediated photosynthesis, resulting notably radiotherapeutic efficacy. Furthermore, chlorophyll from produces reactive species during laser irradiation, further augmenting photosensitizing effect enhancing cell apoptosis. Thus, sequential combination of oxygen-generating algae system with phototherapies has potential create an innovative treatment strategy improve outcome management. Together, our findings novel approach leverages products for provide proof-of-concept evidence future development algae-enhanced photodynamic therapy.

Language: Английский

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ZnO nanomaterials: Green synthesis, toxicity evaluation and new insights in biomedical applications

Journal of Alloys and Compounds, Journal Year: 2021, Volume and Issue: 876, P. 160175 - 160175

Published: May 4, 2021

Language: Английский

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<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 2439 - 2483

Published: April 1, 2020

Abstract: Many types of research have distinctly addressed the efficacy natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these vitro vivo effects not been able to be translated clinical use because several factors such as inefficient systemic delivery bioavailability promising agents that significantly contribute this disconnection. Over past decades, extraordinary advances made successfully on development novel drug systems encapsulation active including organic, inorganic hybrid nanoparticles. The advanced formulas are confirmed benefits over conventional previously manner solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, physical chemical degradation. current review highlights nanocarrier compounds, their method preparation, type ingredients, biomedical applications. Keywords: nanomedicine, metabolite, application, carrier formulation,

Language: Английский

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Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13936 - 13995

Published: May 3, 2021

This Review focuses on the establishment and development of self-assemblies governed by supramolecular interactions between cyclic peptides. The first describes type peptides able to assemble into tubular structures form peptide nanotubes. A range have been identified such properties, including α-peptides, β-peptides, α,γ-peptides, based δ- ε-amino acids. covers design functionalization these expands a recent advance in application materials through their conjugation polymer chains generate peptide–polymer conjugates nanostructures. Review, then, concentrates challenges characterizing systems presents an overview various analytical characterization techniques used date. concludes with critical survey applications nanomaterials obtained from nanotubes, focus biological medical applications, ranging ion channels membrane insertion antibacterial materials, anticancer drug delivery, gene antiviral applications.

Language: Английский

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Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1091 - 1091

Published: May 19, 2022

Plant-based medicines have received a lot of attention in recent years. Such been employed to treat medical conditions since ancient times, and those times only the observed symptoms were used determine dose accuracy, efficacy, therapy. Rather than novel formulations, current research work on plant-based has mostly concentrated medicinal active phytoconstituents. In past decades, however, researchers made significant progress developing “new drug delivery systems” (NDDS) enhance therapeutic efficacy reduce unwanted effects bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, other innovative formulations all created using compounds plant extracts. The can improve solubility, bioavailability, stability, tissue distribution, protection from physical chemical damage, prolonged targeted administration, name few. study summarizes existing development new with focus herbal components.

Language: Английский

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Synthetic Biology: Bottom-Up Assembly of Molecular Systems

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(21), P. 16294 - 16328

Published: Sept. 30, 2022

The bottom-up assembly of biological and chemical components opens exciting opportunities to engineer artificial vesicular systems for applications with previously unmet requirements. modular combination scaffolds functional building blocks enables the engineering complex biomimetic or new-to-nature functionalities. Inspired by compartmentalized organization cells organelles, lipid polymer vesicles are widely used as model membrane investigate translocation solutes transduction signals proteins. functionalization such compartments full control over their composition can thus provide specifically optimized environments synthetic processes. This review aims inspire future endeavors providing a diverse toolbox molecular modules, methodologies, different approaches assemble systems. Important technical practical aspects addressed selected presented, highlighting particular achievements limitations approach. Complementing cutting-edge technological achievements, fundamental also discussed cater inherently background target audience, which results from interdisciplinary nature biology. proteins modules use lipids block copolymers scaffold functionalized explored in detail. Particular emphasis is placed on ensuring controlled these into increasingly Finally, all descriptions presented greater context valuable biocatalysis, biosensing, bioremediation, targeted drug delivery.

Language: Английский

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Skin drug delivery using lipid vesicles: A starting guideline for their development

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 624 - 654

Published: Feb. 17, 2023

Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It an important challenge to design the ideal vesicle, since their properties and features are related, as changes in one affect others. Here, we review main components, preparation characterization methods commonly used, key that lead highly efficient for transdermal delivery purposes. We stand by size, deformability degree loading, most determine further absorption. The interest this technology increasing, demonstrated exponential growth publications on topic. Although long-term preservation scalability issues have limited commercialization lipid products, freeze-drying modern escalation overcome these difficulties, thus predicting higher use technologies market clinical practice.

Language: Английский

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In vivo Biodistribution and Clearance of Magnetic Iron Oxide Nanoparticles for Medical Applications

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4067 - 4100

Published: July 1, 2023

Abstract: Magnetic iron oxide nanoparticles (magnetite and maghemite) are intensively studied due to their broad potential applications in medical biological sciences. Their unique properties, such as nanometric size, large specific surface area, superparamagnetism, allow them be used targeted drug delivery internal radiotherapy by targeting an external magnetic field. In addition, they successfully resonance imaging (MRI), hyperthermia, radiolabelling. The appropriate design of allows delivered the desired tissues organs. biodistribution nanoparticles, eg, cancerous tumors, is increased using Thus, knowledge these essential for applications. It determining whether captured organs or accumulated other tissues, which may lead toxicity. This review article presents main where accumulate. sites first uptake usually liver, spleen, lymph nodes, but with can also lungs, heart, brain. describes factors affecting including shape, charge, coating molecules, route administration. Modern techniques nanoparticle accumulation concentration isolated body vivo presented. Graphical Keywords: biodistribution, biodegradation

Language: Английский

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