Biomarkers in Medicine,
Journal Year:
2021,
Volume and Issue:
15(14), P. 1261 - 1270
Published: Sept. 7, 2021
Background:
This
study
explored
the
clinical
role
of
lncRNA
MEG3
in
rheumatoid
arthritis
(RA)
management.
Materials
&
methods:
Totally,
191
active
RA
patients
were
enrolled,
and
their
expressions
peripheral
blood
monoclonal
cells
detected.
Results:
LncRNA
expression
was
downregulated,
it
negatively
correlated
with
lesion
joints,
inflammation
disease
activity
patients.
Moreover,
increased
during
treatment;
meanwhile
its
increment
treatment
response
remission.
Conclusion:
may
serve
as
a
potential
biomarker
for
monitoring
efficacy
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 28, 2024
Fibroblast-like
synoviocytes
(FLS)
are
important
components
of
the
synovial
membrane.
They
can
contribute
to
joint
damage
through
crosstalk
with
inflammatory
cells
and
direct
actions
on
tissue
pathways
in
rheumatoid
arthritis
(RA).
Recent
evidence
suggests
that,
compared
FLS
normal
tissue,
RA
exhibits
significant
differences
metabolism.
metabolomic
studies
have
demonstrated
that
metabolic
changes,
including
those
glucose,
lipid,
amino
acid
metabolism,
exist
before
synovitis
onset.
These
changes
may
be
a
result
increased
biosynthesis
energy
requirements
during
early
phases
disease.
Activated
T
some
cytokines
conversion
into
abnormalities
pro-inflammatory
phenotypes.
This
one
potential
mechanisms
behind
altered
Targeting
metabolism
inhibit
proliferation,
providing
relief
patients
RA.
In
this
review,
we
aimed
summarize
RA,
analyze
these
alterations,
assess
their
effect
phenotype.
Finally,
advances
challenges
faced
targeting
as
promising
therapeutic
strategy
for
future.
Hereditas,
Journal Year:
2021,
Volume and Issue:
158(1)
Published: Nov. 10, 2021
Hepatocellular
carcinoma
(HCC)
is
one
of
the
leading
causes
cancer-related
death
worldwide
due
to
its
high
degree
malignancy,
incidence,
and
low
survival
rate.
However,
underlying
mechanisms
hepatocarcinogenesis
remain
unclear.
Long
non
coding
RNA
(lncRNA)
has
been
shown
as
a
novel
type
RNA.
lncRNA
by
acting
ceRNA
can
participate
in
various
biological
processes
HCC
cells,
such
tumor
cell
proliferation,
migration,
invasion,
apoptosis
drug
resistance
regulating
downstream
target
gene
expression
signaling
pathways.
Meanwhile,
predict
efficacy
treatment
strategies
for
serve
potential
diagnosis
HCC.
Therefore,
serving
may
become
vital
candidate
biomarker
clinical
treatment.
In
this
review,
epidemiology
HCC,
including
morbidity,
mortality,
regional
distribution,
risk
factors,
current
advances,
was
briefly
discussed,
some
functions
were
summarized
with
emphasis
on
molecular
mechanism
application
lncRNA-mediated
regulatory
network
This
paper
contribute
better
understanding
influence
networks
(ceRNETs)
provide
directions
future
studies.
Non-Coding RNA,
Journal Year:
2021,
Volume and Issue:
7(3), P. 54 - 54
Published: Aug. 31, 2021
The
highly
infectious
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
emerged
as
the
causative
agent
of
disease
2019
(COVID-19)
in
late
2019,
igniting
an
unprecedented
pandemic.
A
mechanistic
picture
characterising
immunopathological
COVID-19
is
developing.
Non-coding
RNAs
(ncRNAs)
constitute
transcribed
but
un-translated
portion
genome
and,
until
recent
decades,
have
been
undiscovered
or
overlooked.
growing
body
research
continues
to
demonstrate
their
interconnected
involvement
immune
response
SARS-CoV-2
and
development
by
regulating
several
its
pathological
hallmarks:
cytokine
storm
syndrome,
haemostatic
alterations,
cell
recruitment,
vascular
dysregulation.
There
also
keen
interest
exploring
possibility
host–virus
RNA–RNA
RNA–RBP
interactions.
Here,
we
discuss
evaluate
evidence
demonstrating
short
long
ncRNAs
use
this
information
propose
hypotheses
for
future
clinical
studies.
Autoimmunity,
Journal Year:
2024,
Volume and Issue:
57(1)
Published: Jan. 22, 2024
Our
previous
study
found
that
Cullin
4B
(CUL4B)
inhibited
rheumatoid
arthritis
(RA)
pathology
through
glycogen
synthase
kinase-3beta
(GSK3β)/canonical
Wnt
signalling
pathway.
In
this
work,
pre-experiment
and
bioinformatics
analysis
suggested
circ_0011058
may
lead
to
the
up-regulation
of
CUL4B
expression
by
inhibiting
miR-335-5p.
Therefore,
we
studied
whether
can
promote
sponging
miR-335-5p
further
pathological
development
RA.
Bioinformatics
prediction,
real-time
quantitative
PCR
(RT-qPCR),
western
blot
(WB),
double
luciferase
reporter
gene
other
relevant
methods
were
used
inhibition
on
RA
its
molecular
mechanism.
Results
showed
was
significantly
increased
in
adjuvant
(AA)
rats
fibroblast-like
synoviocytes
(FLS).
The
knockout
proliferation
AA
FLS
FLS,
decreased
levels
interleukin-1
beta
(IL-1β),
interleukin
6
(IL-6),
8
(IL-8),
matrix
metalloproteinase
3
(MMP3),
fibronectin,
which
had
a
strong
role
promoting
pathology.
Furthermore,
reduced
FLS.
highly
expressed
directly
sponged
miR-335-5p,
led
increase
promoted
activation
GSK3β/canonical
Finally,
confirmed
mediated
roles
development,
circ_0011058/miR-335-5p/CUL4B
signal
axis
involved
This
work
great
significance
for
clarifying
pathology,
needed
establish
potential
therapeutic
target
or
diagnostic
marker
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
12
Published: March 13, 2025
LncRNAs
are
RNA
molecules
of
more
than
200
nucleotides
in
length
and
participate
cellular
metabolism
responses
through
their
diverse
interactomedespite
having
no
protein-coding
capabilities.
Such
significant
interactions
also
implicate
the
presence
lncRNAs
complex
pathobiological
pathways
various
diseases,
affecting
survival
by
modulating
autophagy,
inflammation
apoptosis.
Proliferating
cells
harbour
a
microenvironment
that
mainly
stimulate
growth-specific
activities
such
as
DNA
replication,
repair,
protein
synthesis.
They
recognise
damages
at
macromolecular
level,
preventing
them
from
reaching
next-generation.
have
shown
association
with
events
occurring
towards
proliferation,
regulating
key
dividing
cells,
dysregulation
lncRNA
transcriptome
affects
normal
life-cycle,
promoting
development
cancer.
Furthermore,
demonstrated
an
cancer
growth
progression
governing
cell
growth,
epithelial-mesenchymal
transition
metastasis.
This
makes
attractive
target
for
treatment
can
be
used
marker
diagnosis
prognosis
diseases
due
to
differential
expression
diseased
samples.
review
delves
into
correlation
fundamental
signalling
how
this
crosstalk
shapes
complexity
oncogenic
microhabitat.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 28, 2025
Breast
cancer
(BC)
is
a
malignant
tumor
that
has
the
highest
morbidity
and
mortality
rates
in
female
population,
its
high
tendency
to
metastasize
main
cause
of
poor
clinical
prognosis.
Long
non-coding
RNAs
(lncRNAs)
have
been
extensively
documented
exhibit
aberrant
expression
various
cancers
influence
progression
via
multiple
molecular
pathways.
These
lncRNAs
not
only
modulate
numerous
aspects
gene
cells,
such
as
transcription,
translation,
post-translational
modifications,
but
also
play
crucial
role
reprogramming
energy
metabolism
by
regulating
metabolic
regulators,
which
particularly
significant
advanced
BC.
This
review
examines
characteristics
mechanisms
BC
both
intracellularly
(e.g.,
cell
cycle,
autophagy)
extracellularly
microenvironment).
Furthermore,
we
explore
potential
specific
their
regulatory
factors
markers
therapeutic
targets.
Lastly,
summarize
application
treatment
BC,
aiming
offer
novel
personalized
options
for
patients.
