Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 25, 2022
Coronavirus
disease
2019
(COVID-19)
can
disrupt
the
gut
microbiota
balance,
and
patients
usually
have
intestinal
disorders.
The
intestine
is
largest
immune
organ
of
human
body,
microbes
affect
function
lungs
through
gut-lung
axis.
Many
lines
evidence
support
role
beneficial
bacteria
in
enhancing
immunity,
preventing
pathogen
colonization,
thereby
reducing
incidence
severity
infection.
In
this
article,
we
review
possible
approach
modulating
to
help
prevent
treat
respiratory
tract
infections,
including
COVID-19,
discuss
possibility
using
probiotics
prebiotics
for
purpose.
We
also
mechanism
by
which
micro-flora
regulate
immunity
effects
on
micro-ecological
balance.
Based
understanding,
propose
use
modulate
prevention
or
alleviation
COVID-19
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(2), P. 164 - 164
Published: Feb. 12, 2024
COVID-19
is
a
global
health
threat
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
and
associated
with
significant
increase
in
morbidity
mortality.
The
present
review
discusses
nuclear
factor-kappa
B
(NF-κB)
activation
its
potential
therapeutical
role
treating
COVID-19.
pathogenesis,
the
major
NF-κB
pathways,
involvement
of
SARS-CoV-2
have
been
detailed.
Specifically,
impact
on
managing
has
discussed.
As
central
player
immune
inflammatory
responses,
modulating
could
offer
strategic
avenue
for
infection.
Understanding
pathway’s
aid
developing
treatments
against
SARS-CoV-2.
Further
investigations
into
intricacies
are
required
to
reveal
effective
therapeutic
strategies
combating
infection
Nutrition Research Reviews,
Journal Year:
2021,
Volume and Issue:
36(2), P. 181 - 198
Published: Oct. 20, 2021
Scientists
are
working
to
identify
prevention/treatment
methods
and
clinical
outcomes
of
coronavirus
disease
2019
(COVID-19).
Nutritional
status
diet
have
a
major
impact
on
the
COVID-19
process,
mainly
because
bidirectional
interaction
between
gut
microbiota
lung,
that
is,
gut-lung
axis.
Individuals
with
inadequate
nutritional
pre-existing
imbalance
in
immunity
as
seen
obesity,
diabetes,
hypertension
other
chronic
diseases.
Communication
lungs
or
organs
systems
may
trigger
worse
viral
respiratory
infections.
Thus,
this
review
addresses
new
insights
into
use
probiotics
prebiotics
preventive
strategy
managing
infections
such
highlighting
their
anti-inflammatory
effects
against
main
signs
symptoms
associated
COVID-19.
Literature
search
was
performed
through
PubMed,
Cochrane
Library,
Scopus
Web
Science
databases;
relevant
articles
were
included.
Significant
randomised
trials
suggest
specific
and/or
reduce
diarrhoea,
abdominal
pain,
vomiting,
headache,
cough,
sore
throat,
fever,
infection
complications
acute
distress
syndrome.
These
beneficial
linked
modulation
microbiota,
products
microbial
metabolism
antiviral
activity,
immune-regulatory
properties
Treg
cell
production
function.
There
is
need
conduct
pre-clinical
assess
combined
effect
consuming
these
components
undergoing
current
therapies
for
Heliyon,
Journal Year:
2022,
Volume and Issue:
8(9), P. e10702 - e10702
Published: Sept. 1, 2022
The
COVID-19
pandemic
caused
by
SARS-CoV-2
remains
an
international
concern.
Although
there
are
drugs
to
fight
it,
new
natural
alternatives
such
as
polyphenols
essential
due
their
antioxidant
activity
and
high
antiviral
potential.
In
this
context,
review
reports
the
main
findings
on
effect
of
phenolic
compounds
(PCs)
against
virus.
First,
proven
PCs
different
human
viruses
is
briefly
detailed,
which
serves
a
starting
point
study
anti-COVID-19
targets
(its
proteins)
defined.
Findings
from
in
silico,
vitro
vivo
studies
wide
variety
shown,
emphasizing
mechanism
action,
fundamental
for
drug
design.
Furthermore,
clinical
trials
have
demonstrated
effectiveness
prevention
possible
therapeutic
management
COVID-19.
results
were
complemented
with
information
influence
strengthening/modulating
immune
system.
It
recommended
investigate
vitamins,
minerals,
alkaloids,
triterpenes
fatty
acids,
synergistic
use
PCs,
many
been
successful
SARS-CoV-2.
Based
other
viruses,
evaluation
accepted
also
suggested.
Other
recommendations
limitations
useful
professionals
involved
development
efficient,
safe
low-cost
strategies
based
plant
matrices
rich
PCs.
To
authors'
knowledge,
manuscript
first
evaluate
relationship
between
immunomodulatory
(including
anti-inflammatory
effects)
underlying
mechanisms
relation
interest
general
population
be
informed
about
importance
consuming
foods
bioactive
health
benefits.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 25, 2022
Coronavirus
disease
2019
(COVID-19)
can
disrupt
the
gut
microbiota
balance,
and
patients
usually
have
intestinal
disorders.
The
intestine
is
largest
immune
organ
of
human
body,
microbes
affect
function
lungs
through
gut-lung
axis.
Many
lines
evidence
support
role
beneficial
bacteria
in
enhancing
immunity,
preventing
pathogen
colonization,
thereby
reducing
incidence
severity
infection.
In
this
article,
we
review
possible
approach
modulating
to
help
prevent
treat
respiratory
tract
infections,
including
COVID-19,
discuss
possibility
using
probiotics
prebiotics
for
purpose.
We
also
mechanism
by
which
micro-flora
regulate
immunity
effects
on
micro-ecological
balance.
Based
understanding,
propose
use
modulate
prevention
or
alleviation
COVID-19
