miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay – A review

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 242, P. 154316 - 154316

Published: Jan. 20, 2023

Language: Английский

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Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 353 - 353

Published: Feb. 17, 2024

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels, are primary cause death worldwide, with an immense impact on patient quality life and disability. According to World Health Organization, CVD takes estimated 17.9 million lives each year, where more than four out five deaths due attacks strokes. In decades come, increased prevalence age-related CVD, such as atherosclerosis, coronary artery stenosis, myocardial infarction (MI), valvular disease, failure (HF) will contribute even greater health economic burden global average expectancy increases consequently world’s population continues age. Considering this, it is important focus our research efforts understanding fundamental mechanisms underlying CVD. this review, we cellular senescence mitochondrial dysfunction, which have long been established We also assess recent advances in targeting dysfunction including energy starvation oxidative stress, mitochondria dynamics imbalance, cell apoptosis, mitophagy, therapies that influence both therefore perhaps represent strategies most clinical potential, range, utility.

Language: Английский

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Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

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Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 444 - 444

Published: Feb. 10, 2023

Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and increased probability of death. Cellular senescence has been typically considered as anti-proliferative process; however, the chronic accumulation senescent cells contributes tissue dysfunction aging. In this review, we discuss some most important hallmarks biomarkers cellular with special focus on skin biomarkers, reactive oxygen species (ROS), senotherapeutic strategies eliminate or prevent senescence. Although them are not exclusive senescence, expression senescence-associated beta-galactosidase (SA-β-gal) enzyme seems be reliable biomarker for distinguishing from those arrested cell cycle. The presence stable DNA damage response (DDR) secretory phenotype (SASP) mediators ROS representative Senotherapeutics based natural compounds such quercetin, naringenin, apigenin have shown promising results regarding SASP reduction. These seem cells, likely through inhibition pro-survival signaling pathways. studies still required verify their short- long-term effects, these therapies may effective strategy

Language: Английский

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Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders

Cells, Journal Year: 2023, Volume and Issue: 12(5), P. 753 - 753

Published: Feb. 27, 2023

The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On other hand, premature has begun to be a problem, with numbers younger people suffering aging-related symptoms. Advanced caused by combination factors: lifestyle, diet, external internal factors, as well oxidative stress (OS). Although OS most researched factor, it also least understood. important not only in relation but due its strong impact on neurodegenerative diseases such amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s (PD). In this review, we will discuss process OS, function disorders, prospective therapeutics capable relieving symptoms associated pro-oxidative condition.

Language: Английский

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Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 180 - 180

Published: Jan. 12, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive decline. Although substantial research has been conducted to elucidate the complex pathophysiology of AD, therapeutic approach still limited efficacy in clinical practice. Oxidative stress (OS) established as an early driver several age-related diseases, including neurodegeneration. In increased levels reactive oxygen species mediate neuronal lipid, protein, nucleic acid peroxidation, mitochondrial dysfunction, synaptic damage, inflammation. Thus, identification novel antioxidant molecules capable detecting, preventing, counteracting AD onset progression utmost importance. However, although studies have published, comprehensive up-to-date overviews principal anti-AD agents harboring properties remain scarce. this narrative review, we summarize role vitamins, minerals, flavonoids, non-flavonoids, mitochondria-targeting molecules, organosulfur compounds, carotenoids non-enzymatic antioxidants with diagnostic, preventative, potential, thereby offering insights into relationship between OS

Language: Английский

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Single-cell and spatial RNA sequencing reveal the spatiotemporal trajectories of fruit senescence

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 10, 2024

The senescence of fruit is a complex physiological process, with various cell types within the pericarp, making it highly challenging to elucidate their individual roles in senescence. In this study, single-cell expression atlas pericarp pitaya (Hylocereus undatus) constructed, revealing exocarp and mesocarp cells undergoing most significant changes during process. Pseudotime analysis establishes cellular differentiation gene trajectories Early-stage oxidative stress imbalance followed by activation resistance cells, subsequently senescence-associated proteins accumulate at late-stage central role early response factor HuCMB1 unveiled regulatory network. This study provides spatiotemporal perspective for deeper understanding dynamic process plants.

Language: Английский

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Oxidative Stress and Cell Senescence Process

Antioxidants, Journal Year: 2022, Volume and Issue: 11(9), P. 1718 - 1718

Published: Aug. 30, 2022

Oxidative stress due to excessive amounts of reactive oxygen species (ROS) and nitrogen (RNS) plays a leading role in damages macromolecules and, as such, it represents key driver numerous physio-pathological events, including cellular senescence [...].

Language: Английский

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Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5542 - 5542

Published: Aug. 28, 2022

Chronic obstructive pulmonary disease (COPD) is an increasing and major global health problem. COPD also the third leading cause of death worldwide. Oxidative stress (OS) takes place when various reactive species free radicals swamp availability antioxidants. Reactive nitrogen species, oxygen (ROS), their counterpart antioxidants are important for host defense physiological signaling pathways, development progression inflammation. During disturbance normal steady states, imbalances between oxidants might induce pathological mechanisms that can further result in many non-respiratory respiratory diseases including COPD. ROS be either endogenously produced response to infectious pathogens fungi, viruses, or bacteria, exogenously generated from several inhaled particulate gaseous agents some occupational dust, cigarette smoke (CS), air pollutants. Therefore, targeting systemic local OS with therapeutic such as small molecules increase endogenous regulate redox/antioxidants system effective approach treating Various thiol-based fudosteine, erdosteine, carbocysteine, N-acetyl-L-cysteine have capacity thiol content lungs. Many synthetic inhibitors/blockers protein carbonylation lipid peroxidation, catalytic superoxide dismutase mimetics, spin trapping effectively modulate CS-induced its resulting cellular alterations. Several clinical pre-clinical studies demonstrated these decrease affect expressions pro-inflammatory genes involved redox glutathione biosynthesis. In this article, we summarized role pathogenesis. Furthermore, particularly focused on potential numerous chemicals, treatment

Language: Английский

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Enzymatic hydrolysis of soy protein to high moisture textured meat analogue with emphasis on antioxidant effects: As a tool to improve techno-functional property

Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 50, P. 102700 - 102700

Published: May 11, 2023

Language: Английский

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