Journal of Functional Foods,
Journal Year:
2022,
Volume and Issue:
92, P. 105076 - 105076
Published: April 16, 2022
Elastin
peptides
display
a
wide
range
of
biological
activities.
This
study
aimed
to
investigate
the
ameliorative
effect
tuna
elastin
on
adjuvant-induced
arthritis
(AIA).
The
daily
administration
markedly
downregulated
levels
proinflammatory
cytokines
and
upregulated
immunosuppressive
in
serum,
bone,
colon
AIA
model.
16S
rRNA
sequencing
showed
that
peptide-treated
mice
exhibited
reversed
gut
microbiota
dysbiosis
increased
abundance
Lactobacillus
Clostridium.
Additionally,
metabolomics
indicated
short-chain
fatty
acid
(SCFAs)
production
was
mice.
ameliorating
effects
were
transmitted
by
transplanting
fecal
from
treated
with
high
peptides.
These
results
indicate
potential
as
beneficial
functional
food
ameliorates
rheumatoid
arthritis.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2022,
Volume and Issue:
21(5), P. 3931 - 3962
Published: Aug. 29, 2022
Abstract
A
large
number
of
epidemiological
studies
have
shown
that
consumption
fruits,
vegetables,
and
beverages
rich
in
(poly)phenols
promote
numerous
health
benefits
from
cardiovascular
to
neurological
diseases.
Evidence
on
has
been
applied
mainly
flavonoids,
yet
the
role
phenolic
acids
largely
overlooked.
Such
phenolics
present
food
combine
with
those
resulting
gut
microbiota
catabolism
flavonoids
chlorogenic
produced
by
endogenous
pathways,
concentrations
low
molecular
weight
metabolites
human
circulation.
Independently
origin,
intervention
using
diets
(poly)phenols,
a
total
137
detected
quantified
circulation
unknown
biological
function.
In
this
review,
we
will
pinpoint
two
main
aspects
metabolites:
(i)
responsible
for
their
generation,
(ii)
analysis
(quali‐
quantitative)
respective
pharmacokinetics.
doing
so,
aim
drive
scientific
advances
regarding
ubiquitous
roles
physiologically
relevant
under
(patho)physiologically
conditions
humans.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(8), P. e18991 - e18991
Published: Aug. 1, 2023
Chronic
kidney
disease
(CKD)
refers
to
a
range
of
various
pathophysiological
processes
correlated
with
abnormal
renal
function
and
progressive
loss
in
GFR.
Just
as
dysbiosis
altered
pathology
the
gut
are
accompanied
hypertension,
which
is
significant
CKD
risk
factor.
Gut
patients
associated
an
elevated
levels
uremic
toxins,
turn
increases
progression.
According
research
results,
gut-kidney
axis
has
role
formation
stones,
also
IgAN.
A
number
researchers
have
categorized
microbiota
enterotypes,
others,
skeptical
theory
suggested
biomarkers
describe
taxa
that
related
lifestyle,
nutrition,
status.
Metabolome-microbiome
studies
been
used
investigate
interactions
host-gut
terms
involvement
metabolites
these
yielded
promising
results.
The
correlation
between
requires
further
multi-omic
researches.
Also,
regard
systems
biology,
on
communication
network
proteins
transporters
such
SLC
ABC,
can
help
us
achieve
deeper
understanding
gut-liver-kidney
thus
provide
new
horizons
treatment
patients.
Probiotic-based
approach
reduce
poisoning,
accomplished
by
swallowing
microbes
those
catalyze
URS
gut.
If
comprehensive
carried
out,
we
will
know
about
probiotics
impact
slowing
failure
progression
reducing
inflammatory
markers.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1138 - 1138
Published: Feb. 24, 2023
Hippuric
acid
(HA)
is
a
metabolite
resulting
from
the
hepatic
glycine
conjugation
of
benzoic
(BA)
or
gut
bacterial
metabolism
phenylalanine.
BA
generally
produced
by
microbial
metabolic
pathways
after
ingestion
foods
vegetal
origin
rich
in
polyphenolic
compounds,
namely,
chlorogenic
acids
epicatechins.
It
can
also
be
present
foods,
either
naturally
artificially
added
as
preservative.
The
plasma
and
urine
HA
levels
have
been
used
nutritional
research
for
estimating
habitual
fruit
vegetable
intake,
especially
children
patients
with
diseases.
has
proposed
biomarker
aging,
since
its
influenced
presence
several
age-related
conditions,
including
frailty,
sarcopenia
cognitive
impairment.
Subjects
physical
frailty
exhibit
reduced
HA,
despite
fact
that
excretion
tends
to
increase
aging.
Conversely,
subjects
chronic
kidney
disease
clearance,
retention
may
exert
toxic
effects
on
circulation,
brain
kidneys.
With
regard
older
multimorbidity,
interpreting
result
particularly
challenging
because
at
crossroads
between
diet,
microbiota,
liver
function.
Although
these
considerations
not
make
ideal
aging
trajectories,
study
clearance
provide
valuable
information
disentangling
complex
interaction
multimorbidity.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 27, 2023
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes,
which
increases
the
risk
renal
failure
and
causes
high
global
disease
burden.
Due
to
lack
sustainable
treatment,
DN
has
become
primary
cause
end-stage
worldwide.
Gut
microbiota
its
metabolites
exert
critical
regulatory
functions
in
maintaining
host
health
are
associated
with
many
pathogenesis
aging-related
chronic
diseases.
Currently,
theory
gut–kidney
axis
opened
novel
angle
understand
relationship
between
gut
multiple
kidney
In
recent
years,
accumulating
evidence
revealed
that
their
play
an
essential
role
pathophysiologic
processes
through
axis.
this
review,
we
summarize
current
investigations
microbial
involvement
progression
DN,
further
discuss
potential
microbiota-targeted
therapeutic
approaches
for
DN.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 19, 2023
Diabetic
kidney
disease
(DKD)
is
one
of
the
major
microvascular
complications
diabetes
mellitus
and
also
serious
risk
factors
in
cardiovascular
events,
end-stage
renal
disease,
mortality.
DKD
associated
with
diversified,
compositional,
functional
alterations
gut
microbiota.
The
interaction
between
microbiota
host
mainly
achieved
through
metabolites,
which
are
small
molecules
produced
by
microbial
metabolism
from
exogenous
dietary
substrates
endogenous
compounds.
plays
a
critical
role
pathogenesis
producing
multitudinous
metabolites.
Nevertheless,
detailed
mechanisms
its
metabolites
involved
occurrence
development
have
not
been
completely
elucidated.
This
review
summarizes
specific
classes
microbiota-derived
aims
to
explore
molecular
pathophysiology
progression,
recognizes
biomarkers
for
screening,
diagnosis,
prognosis
DKD,
as
well
provides
novel
therapeutic
strategies
DKD.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 14, 2022
Disturbance
of
circulating
metabolites
and
disorders
the
gut
microbiota
are
involved
in
progression
diabetic
kidney
disease
(DKD).
However,
there
is
limited
research
on
relationship
between
serum
microbiota,
their
involvement
DKD.
In
this
study,
using
an
experimental
DKD
rat
model
induced
by
combining
streptozotocin
injection
unilateral
nephrectomy,
we
employed
untargeted
metabolomics
16S
rRNA
gene
sequencing
to
explore
metabolic
profile
structure
function
microbiota.
Striking
alterations
took
place
140
metabolites,
as
well
composition
These
changes
were
mainly
associated
with
carbohydrate,
lipid,
amino
acid
metabolism.
these
pathways,
isomaltose,
D-mannose,
galactonic
acid,
citramalic
prostaglandin
B2
significantly
upregulated.
3-(2-Hydroxyethyl)indole,
3-methylindole,
indoleacrylic
downregulated
critical
model.
Furthermore,
levels
three
indoles
restored
after
treatment
traditional
Chinese
herbal
medicine
Tangshen
Formula.
At
genera
level,
g_Eubacterium_nodatum_
group,
g_Lactobacillus
,
g_Faecalibaculum
most
Notably,
lipid
had
a
strong
DKD-related
parameters
especially
negatively
related
mesangial
matrix
area.
Serum
indices
(TG
TC)
UACR
directly
certain
microbial
genera.
conclusion,
present
verified
anomalous
progression.
We
also
identified
potential
targets
for
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 18, 2022
Type
2
diabetes
mellitus
(T2DM)
and
T2DM-related
complications
[such
as
retinopathy,
nephropathy,
cardiovascular
diseases
(CVDs)]
are
the
most
prevalent
metabolic
diseases.
Intriguingly,
overwhelming
findings
have
shown
a
strong
association
of
gut
microbiome
with
etiology
these
diseases,
including
role
aberrant
bacterial
metabolites,
increased
intestinal
permeability,
pathogenic
immune
function
affecting
host
metabolism.
Thus,
deciphering
specific
microbiota,
related
mechanisms
to
by
combined
analyses
metagenomics
metabolomics
data
can
lead
an
innovative
strategy
for
treatment
Accordingly,
this
review
highlights
advanced
knowledge
about
characteristics
microbiota
in
how
it
be
associated
pathogenesis
Also,
recent
studies
providing
new
perspective
on
microbiota-targeted
therapies
included.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115395 - 115395
Published: Aug. 31, 2023
In
recent
years,
the
incidence
rate
of
diabetes
mellitus
(DM),
including
type
1
mellitus(T1DM),
2
mellitus(T2DM),
and
gestational
(GDM),
has
increased
year
by
become
a
major
global
health
problem.
DM
can
lead
to
serious
complications
macrovascular
microvascular.
Tryptophan
(Trp)
is
an
essential
amino
acid
for
human
body.
Trp
metabolized
in
body
through
indole
pathway,
kynurenine
(Kyn)
pathway
serotonin
(5-HT)
regulated
intestinal
microorganisms
varying
degrees.
These
three
metabolic
pathways
have
extensive
regulatory
effects
on
immune,
endocrine,
neural,
energy
metabolism
systems
body,
are
related
physiological
pathological
processes
various
diseases.
The
key
enzymes
metabolites
also
deeply
involved
pathogenesis
DM,
playing
important
role
pancreatic
function,
insulin
resistance
(IR),
barrier,
angiogenesis.
its
complications,
there
disruption
balance.
Several
therapy
approaches
been
proven
modify
tryptophan
metabolism.
becoming
new
area
focus
prevention
care.
This
paper
reviews
impact
alterations
these
diseases,
expecting
provide
entry
points
treatment
complications.
