International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 155 - 169
Published: Jan. 1, 2024
Background:
Targeted
delivery
systems
have
been
developed
to
improve
cancer
treatment
by
reducing
side
effects
and
enhancing
drug
efficacy.
Geraniol,
a
natural
product,
has
demonstrated
promising
anti-cancer
in
various
types,
including
prostate
cancer,
which
is
the
most
commonly
diagnosed
men.
Hyaluronic
acid
(HA),
carrier
targeting
CD44-positive
cells,
can
be
utilized
targeted
system.
Purpose:
This
study
investigated
efficacy
of
conjugate
HA
geraniol
linked
via
disulfide
bond
linker
(HA-SS-Geraniol)
cancer.
Materials
Methods:
The
cytotoxicity
HA-SS-Geraniol
was
evaluated
on
human
PC-3
cells.
Flow
cytometry
used
assess
its
mitochondrial
membrane
potential,
apoptosis,
cell
cycle
arrest.
Additionally,
proteomic
analysis
conducted
explore
underlying
mechanism
action
induced
treatment.
A
subcutaneous
xenograft
tumor
model
established
nude
mice
evaluate
toxicity
vivo.
Results:
results
that
exhibited
potent
against
cells
inducing
potential
loss
apoptosis
vitro.
further
supported
hypothesis
induces
death
through
mitochondria-mediated
as
evidenced
differential
protein
expression.
vivo
mouse
confirmed
safety
ability
inhibit
growth.
Conclusion:
holds
promise
biologically
safe
potentially
effective
therapeutic
agent
for
Its
system
utilizing
shows
improving
therapy.
Keywords:
geraniol,
hyaluronic
acid,
nanoparticle,
proteomics
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2615 - 2615
Published: Jan. 30, 2023
The
marine
polysaccharide
fucoidan
(FUC)
is
a
promising
polymer
for
pharmaceutical
research
and
development
of
novel
drug
delivery
systems
with
modified
release
targeted
delivery.
presence
sulfate
group
in
the
makes
FUC
an
excellent
candidate
formation
interpolyelectrolyte
complexes
(PECs)
various
polycations.
However,
due
to
structural
diversity
FUC,
design
FUC-based
nanoformulations
challenging.
This
review
describes
main
strategies
use
PECs
develop
improved
biopharmaceutical
properties,
including
nanocarriers
form
FUC-chitosan
pH-sensitive
oral
delivery,
systems,
polymeric
nanoparticles
hydrophobic
(e.g.,
FUC-zein
PECs,
core-shell
structures
obtained
by
layer-by-layer
self-assembly
method,
self-assembled
hydrophobically
particles).
importance
complex
study
structure,
process
based
on
it
obtaining
reproducible
desired
also
discussed.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 4, 2024
Abstract
The
multifaceted
chemo-immune
resistance
is
the
principal
barrier
to
achieving
cure
in
cancer
patients.
Identifying
a
target
that
critically
involved
chemo-immune-resistance
represents
an
attractive
strategy
improve
treatment.
iRhom1
plays
role
cell
proliferation
and
its
expression
negatively
correlated
with
immune
infiltration.
Here
we
show
decreases
chemotherapy
sensitivity
by
regulating
MAPK14-HSP27
axis.
In
addition,
inhibits
cytotoxic
T-cell
response
reducing
stability
of
ERAP1
protein
ERAP1-mediated
antigen
processing
presentation.
To
facilitate
therapeutic
translation
these
findings,
develop
biodegradable
nanocarrier
effective
codelivery
iRhom
pre-siRNA
(pre-siiRhom)
chemotherapeutic
drugs.
This
tumor
targeting
penetration
through
both
enhanced
permeability
retention
effect
CD44-mediated
transcytosis
endothelial
cells
as
well
cells.
Inhibition
further
facilitates
uptake
inhibition
CD44
cleavage.
Co-delivery
pre-siiRhom
agent
leads
antitumor
efficacy
activated
microenvironment
multiple
models
female
mice.
Targeting
together
could
represent
overcome
Future Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Jan. 5, 2024
Abstract
Background
Medical
fraternity
are
continuously
pitching
toward
the
development
of
novel
mechanisms
to
combat
menace
cancer
and
enhance
efficacy
prevailing
molecules.
During
drug
phase,
majority
new
molecular
entity
pose
a
threat
due
hydrophobic
nature,
that
compromises
its
bioavailability
upon
administration.
These
suboptimal
accumulation
low
loading
hampers
clinical
translation
in
therapy.
Main
body
abstract
Nanotechnology
with
valuable
advantages
create
possibilities
accelerate
treatment.
Compared
matrix-based
formulations,
nanocrystals
(NCs)
smaller
size,
high
loading,
active
targeting,
extended
circulation,
great
structural
stability,
tailored
dissolution,
being
carrier
free
have
sparked
lot
interest
delivery.
Many
drugs
were
explored
as
NCs
such
as—doxorubicin,
paclitaxel,
campothecin
so
on.
However,
premature
leakage
clearance
by
mononuclear
phagocytosis
system
lead
some
obstacles
applications
NCs.
Conclusion
In
recent
years,
strategies
leading
surface
modification
applied
improve
uncontrolled
release
targeting
efficiency
tumor
cells.
The
current
review
sheds
light
on
various
properties
nanocrystals,
brief
insights
fabricating
techniques,
approaches
for
NCs,
their
imaging
therapeutics.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 28, 2025
This
project
aims
to
construct
cRGD
functionalized
mesoporous
silica
nanoparticles
and
modified
for
the
diagnosis
treatment
of
tumors,
providing
new
ideas
targeted
therapy
tumors.
The
were
doped
with
gadolinium
in
situ
provide
excellent
imaging;
was
coupled
on
particle
surface
confer
targeting;
hyaluronic
acid
loaded
onto
particles
by
electrostatic
adsorption,
thereby
improving
biocompatibility
prolonging
their
vivo
circulation
time.Taking
pancreatic
cancer
as
a
model,
we
studied
its
targeting
ability
phagocytosis
cells;
Using
methods
such
cell
growth
experiments
flow
cytometry,
anti-cancer
effect
pro
apoptotic
system
studied.
In
distribution,
tumor
therapeutic
efficacy
evaluated
mouse
model
tumors.Evaluate
bioavailability
enrichment
tissue
using
MRI
technology.
Evaluate
safety
through
changes
volume,
histopathological
examination,
prognosis.
Characterization
synthesis
results
proved
that
cRGD-HA-DOX-Gd2O3@MSN
(cHDG@MSN)
successfully
synthesized
size
230.83
±
12.36
nm.In
vitro
drug
release
DOX
carried
out
at
different
pH
values
(5.5
7.4),
where
only
up
22.65%
7.4,
whereas
increased
78.75%
=
5.5.The
confirm
responsiveness
this
nanocarrier
platform.The
cytotoxicity
studies
showed
cHDG@MSN
itself
is
not
cytotoxic.
Biosafety
evaluation
hemolysis
test
confirmed
probe
highly
biocompatible.Notably,
Gd3+
significantly
enhanced
T1
contrast
according
MR
imaging
results.The
apoptosis
rates
SW1990
cells
treated
PBS,
cytometry
13.97%,
18.38%
29.02%,
respectively,
demonstrating
effectiveness
nanoprobes
cellular
level.
Animal
demonstrated
pathological
level
level.Cells
animals
effectively
inhibited
proliferation
cells.
research
further
verified
sensitivity
constructed
compound
delivery
achieve
accurate
