Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 586 - 586

Published: Feb. 27, 2023

Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.

Language: Английский

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GAS5 lncRNA: A biomarker and therapeutic target in breast cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424

Published: June 20, 2024

Language: Английский

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Anticancer potential of Allium sativum against triple-negative breast cancer cells: Evidence from ROS-mediated cell cycle arrest and apoptosis

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 179, P. 31 - 38

Published: Feb. 8, 2025

Language: Английский

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Gaillardin inhibits autophagy and induces apoptosis in MCF-7 breast cancer cells by regulating JAK/STAT pathway

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Jan. 22, 2024

Language: Английский

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Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract The 2022 US Cancer Statistics show that breast cancer is one of the most common cancers in women. Epidemiology has shown adding flavonoids to diet inhibits arise particular women, such as cervical cancer, ovarian and cancer. Although there have been research reports on apigenin (API) its anti-tumor effect potential mechanism not yet clarified. Therefore, this study, we used 4T1 cells a xenograft tumor mouse model investigate antitumor API underlying mechanism. In vitro, MTT, transwell, staining, western blotting inhibitory molecular vivo by establishing model, using immunohistochemistry, flow cytometry study solid tumors immune microenvironment. results showed can induce cell apoptosis through PI3K/AKT/Nrf2 pathway improve microenvironment mice with tumors, thereby inhibiting growth Thus, may be promising agent for treatment.

Language: Английский

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Mechanism of triptolide regulating proliferation and apoptosis of hepatoma cells by inhibiting JAK/STAT pathway

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract This study was to analyze the effect of triptolide (TPL) on proliferation, apoptosis, and relationship between TPL Janus kinase/signal transducer activator transcription signaling pathway in hepatoma cells. HepG2 cell line selected as experimental object divided into control, low-dose TPL, medium-dose high-dose group. The control group did not receive any drug treatment, while low, medium, groups were treated with at concentrations 0.02, 0.05, 0.10 μM, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, flow cytometry, western blot used detach mechanism. proliferation inhibition rate each dose lower than that group, increased increase ( P < 0.05). apoptosis higher expression phosphorylated kinase 1 (p-JAK1) signal 3 (p-STAT3) protein cells p-JAK1 p-STAT3 decreased 10 ng/mL transforming growth factor-beta + reduced activity B-cell lymphoma/leukemia-2-associated X (Bax) cysteine aspartic acid protease (Caspase)-3/9 raised lymphoma/leukemia-2 (Bcl-2) With dose, Bax Caspase-3/9 increased, Bcl-2 As an anti-liver cancer agent, inhibits hepatocellular carcinoma promotes apoptosis. mechanism may involve inhibiting 1/signal activation apoptosis-related pathways.

Language: Английский

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Plant-derived bioactive phytochemicals as potential compounds for breast cancer prevention and pharmacotherapy: Efficacy, safety, and mechanisms

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 225 - 241

Published: Jan. 1, 2025

Language: Английский

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Phyto-mediated fabrication of silver nanoparticles from Scrophularia striata extract (AgNPs-SSE): a potential inducer of apoptosis in breast cancer cells

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 29, 2025

Language: Английский

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Baicalin and baicalein against myocardial ischemia-reperfusion injury: a review of the current documents

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102772 - 102772

Published: Feb. 5, 2025

Language: Английский

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Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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