Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

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Bio-evaluations of sericin coated hesperidin nanoparticles for gastric ulcer management

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113762 - 113762

Published: Jan. 17, 2024

Language: Английский

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TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(3)

Published: March 1, 2024

Abstract Tribbles pseudokinase 3 (TRIB3) has been identified recently as a novel oncogene in several cancers. Still, further extensive research is imperative to elucidate its function and the molecular mechanisms underlying involvement progression of head neck squamous cell carcinoma (HNSCC). In our study, we found that TRIB3 silencing significantly promoted death by inducing ferroptosis. The interaction with Transcription Factor 4 (TCF4) β-catenin created heterotrimeric complex, which directly interacts ALOXE3 promoter, detrimentally impacting activation. consequential partial neutralization ferroptosis induced deficiency observed through implementation knockdown. Furthermore, study demonstrated inhibitor hesperidin, targeting TRIB3, not only reduced malignancy but also ferroptosis, thereby suppressing tumor growth. Overall, findings unequivocally validate proposition precipitates iron mechanism, indicating strategic could emerge an innovative therapeutic strategy for HNSCC.

Language: Английский

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Unveiling the Chemistry of Citrus Peel: Insights into Nutraceutical Potential and Therapeutic Applications

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1681 - 1681

Published: May 27, 2024

The recent millennium has witnessed a notable shift in consumer focus towards natural products for addressing lifestyle-related disorders, driven by their safety and cost-effectiveness. Nutraceuticals functional foods play an imperative role meeting nutritional needs offering medicinal benefits. With increased scientific knowledge awareness, the significance of healthy lifestyle, including diet, reducing disease risk is widely acknowledged, facilitating access to diverse safer diet longevity. Plant-based rich phytochemicals are increasingly popular effectively utilized management. Agricultural waste from plant-based being recognized as valuable source nutraceuticals dietary interventions. Citrus peels, known flavonoids, emerging promising health-promoting ingredient. Globally, citrus production yields approximately 15 million tons by-products annually, highlighting substantial potential utilizing phyto-therapeutic nutraceutical applications. peels with concentrations ranging 2.5 5.5 g/100 g dry weight, depending on variety. most abundant flavonoids peel include hesperidin naringin, well essential oils monoterpenes like limonene. extracts exhibit high antioxidant capacity, DPPH radical scavenging activities 70 90%, comparable synthetic antioxidants BHA BHT. Additionally, present have been found properties, which can help reduce oxidative stress 30% cardiovascular 25%. Potent anti-inflammatory effects also demonstrated, inflammatory markers such IL-6 TNF-α up 40% cell culture studies. These findings highlight diet-based therapies.

Language: Английский

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Nanoparticle‐Based Drug Delivery Platform for Simultaneous Administration of Phytochemicals and Chemotherapeutics: Emerging Trends in Cancer Management

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research exploring new approaches to improve efficacy reduce its effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays crucial role delivering often‐hydrophobic drugs, enhancing their bioavailability solubility. This area represents significant convergence nanotechnology both conventional pharmaceuticals botanical compounds. Global studies increasingly demonstrating the potential combination therapies inhibit cell growth laboratory preclinical models. These suggest synergistic or additive effects that lead improved treatment outcomes. article focuses on recent advancements nano‐drug delivery systems, specifically those designed for simultaneous phytochemicals. It explores selection phytochemicals based anticancer properties, outlines design considerations nanocarriers, discusses how physicochemical characteristics influence release kinetics. Additionally, review examines nanoformulations integrate synthetic natural components, highlighting herbal oils medicines treatment.

Language: Английский

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Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 3, 2024

Abstract This work examines the capacity of Naringin and Rutin to influence DNA damage response (DDR) pathway by investigating their interactions with key DDR proteins, including PARP-1, ATM, ATR, CHK1, WEE1. Through a combination in silico molecular docking vitro evaluations, we investigated cytotoxic genotoxic effects these compounds on MDA-MB-231 cells, comparing them normal human fibroblast cells (2DD) quiescent (QFC). The research found that had strong affinities for indicating specifically regulate pathways cancer cells. Both exhibited preferential cytotoxicity towards while preserving vitality 2DD as demonstrated experiments conducted at dose 10 µM. comet performed particularly QFC provide valuable information impact Rutin, highlighting targeted initiation need use precise cell models appropriately evaluate toxicity genotoxicity is emphasized this discrepancy. In addition, ADMET drug-likeness investigations have pharmacological potential compounds; however, they also pointed out necessity optimization improve therapeutic profiles. antioxidant capabilities were assessed using DPPH free radical scavenging assays concentration results confirmed both role reducing oxidative stress, hence enhancing anticancer effects. Overall, show medicines modulating treatment. They exhibit selective sparing possess properties. analysis enhances our understanding uses natural chemicals treatment, supporting more mechanisms action clinical effectiveness.

Language: Английский

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Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 22, 2024

Cancer refers to the proliferation and multiplication of aberrant cells inside human body, characterized by their capacity proliferate infiltrate various anatomical regions. Numerous biochemical pathways signaling molecules have an impact on cancer auto biogenesis process. The regulation crucial cellular processes necessary for cell survival proliferation, which are triggered phytochemicals, is significantly influenced pathways. These or components regulated phytochemicals. Medicinal plants a significant reservoir diverse anticancer medications employed in chemotherapy. effects phytochemicals mediated several methods, including induction apoptosis, cessation cycle, inhibition kinases, prevention carcinogenic substances. This paper analyzes phytochemistry seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, saponins, focusing involvement MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, actin dynamics. Hence, this review has examined range encompassing structural characteristics potential mechanisms. It underscored significance plant-derived bioactive compounds cancer, utilizing molecular In addition, endeavor also seeks incentivize scientists carry out clinical trials derived from plants.

Language: Английский

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Antioxidant Compounds and Health Benefits of Citrus Fruits

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1526 - 1526

Published: July 30, 2023

Recent evidence emanating from epidemiological prospective studies shows that increased intakes of antioxidant-rich fruits, vegetables, and legumes are associated with a lower risk developing chronic oxidative stress-related diseases like cardiovascular cancer, as well cardiovascular, all-cause mortality rates [...]

Language: Английский

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Nutritional, antioxidant and biological activity characterization of orange peel flour to produce nutraceutical gluten-free muffins

Food & Function, Journal Year: 2024, Volume and Issue: 15(16), P. 8459 - 8476

Published: Jan. 1, 2024

Celiac disease – a prevalent food intolerance requires strict adherence to lifelong gluten-free (GF) diet as the only effective treatment.

Language: Английский

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A comprehensive review of the therapeutic potential of citrus bioflavonoid hesperidin against lifestyle-related disorders

Cogent Food & Agriculture, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 4, 2023

The fruits of citrus family are rich in flavonoids with superior antioxidant properties; bioactive components potentially beneficial without adverse effects or cytotoxicity healthy individuals. Citrus fruit peel contains ample amount hesperidin which is flavanone glycoside and has showed effective role biological systems as an anti-inflammatory compound. Different studies have investigated such roles hesperidin. Due to potential its derivatives, these compounds been intensively studied for their anti-cancer cardio protective perspective. This review article a collection updated data covering different aspects like occurrence, physical chemical composition, pharmacokinetics safety compounds. Moreover, against lifestyle-related metabolic syndromes mechanistic perspective also extensively discussed this article.

Language: Английский

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