The role of astrocytes response triggered by hyperglycaemia during spinal cord injury DOI
Cynthia Sámano, Graciela L. Mazzone

Archives of Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 18

Published: Oct. 5, 2023

AbstractObjective: This manuscript aimed to provide a comprehensive overview of the physiological, molecular, and cellular mechanisms triggered by reactive astrocytes (RA) in context spinal cord injury (SCI), with particular focus on cases involving hyperglycaemia.Methods: The compilation articles related astrocyte responses neuropathological conditions, specific emphasis those SCI hyperglycaemia, was conducted searching through databases including Science Direct, Web Science, PubMed.Results Conclusions: article explores dual role both neurophysiological neurodegenerative conditions within central nervous system (CNS). In aftermath undergo transformation into RA, adopting distinct phenotype. While there are currently no approved therapies for SCI, various therapeutic strategies have been proposed alleviate detrimental effects RAs following hyperglycemia. These show promising potential treatment its likely comorbidities.Keywords: Reactive astrocytesspinal injuryhyperglycaemia AcknowledgementThe authors would like thank Dr. Carly McCarthy valuable comments assistance improving manuscript's English language.Author contributionsCS contributed conception principal ideas, CS GM wrote first draft manuscript, performed graphic design thoroughly proofread last version. Both submitted version.Disclosure statementThe author(s) declared conflicts interest respect research, authorship, and/or publication this article.Data availability statementData sharing not applicable article, since data sets were generated or analysed during current study. All information obtained from public library, National Library Medicine (National Centre Biotechnology Information, https://pubmed.ncbi.nlm.nih.gov).Additional informationFundingCS supported Departamento de Ciencias Naturales (DCN) la División e Ingeniería (DCNI) UAM-Cuajimalpa, under grant project #47301025. Universidad Austral, CONICET, Fund Scientific Technological Research (FONCYT) Ministry Tech. Productive Argentina, (PICT-2020-SERIEA-00928).

Language: Английский

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders DOI Open Access

Yueke Zhou,

Cheng Qian, Yu Tang

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(11), P. 4999 - 5016

Published: July 25, 2023

Abstract Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity has extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, reactive oxygen species (ROS). Quercetin also demonstrated to exert a striking antiinflammatory effect mainly by inhibiting production cytokines, reducing expression cyclooxygenase lipoxygenase, preserving integrity mast cells. By regulating oxidative stress inflammation, which are regarded as two critical processes involved defense regular physiological operation biological systems, validated be effective treating variety disorders. Symptoms these reactions linked degenerative metabolic disorders, syndrome, cardiovascular, neurodegeneration, cancer, nonalcoholic fatty liver disease. Despite that evidence demonstrates antioxidants employed prevent excessive inflammatory processes, there still concerns regarding expense, accessibility, side agents. Notably, natural products, especially those derived from plants, widely accessible, affordable, generally safe. this review, abilities active ingredient application stress‐related disorders outlined detail.

Language: Английский

Citations

33
Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke DOI
Nan Qiao,

Zhaohong An,

Zeyu Fu

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 949, P. 175717 - 175717

Published: April 11, 2023

Language: Английский

Citations

15
A review of how the saffron (Crocus sativus) petal and its main constituents interact with the Nrf2 and NF-κB signaling pathways DOI
Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(9), P. 1879 - 1909

Published: April 17, 2023

Language: Английский

Citations

13
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier DOI Creative Commons

Eduardo Cazalla,

Antonio Cuadrado, Ángel J. García‐Yagüe

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 21, 2024

The Blood-Brain Barrier (BBB) is a complex and dynamic interface that regulates the exchange of molecules cells between blood central nervous system. It undergoes structural functional throughout oxidative stress inflammation, which may compromise its integrity contribute to pathogenesis neurodegenerative diseases. Maintaining BBB utmost importance in preventing wide range neurological disorders. NRF2 main transcription factor cellular redox balance inflammation-related gene expression. has also demonstrated potential role regulating tight junction contributing inhibition ECM remodeling, by reducing expression several metalloprotease family members involved maintaining function. Overall, we review current insights on addressing protection against effects dysfunction, discuss involvement maintenance different neuropathological diseases, as well as, some activators have been used vitro vivo animal models for barrier dysfunction. Thus, emerging evidence suggests upregulation target genes could suppress stress, neuroinflammation, restore integrity, increase protection.

Language: Английский

Citations

4
Current advances on the phytochemistry, pharmacology, quality control and applications of Anoectochilus roxburghii DOI Creative Commons
X.L. Zou, Kexin Zhang,

Xuezhen Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Anoectochilus roxburghii (Wall.) Lindl. (AR) is a perennial herb that has long been used as medicinal and edible plant. In Traditional Chinese Medicine (TCM), AR utilized to treat various diseases including hyperuricemia, type 2 diabetes mellitus, cancers inflammatory diseases. Recent advances in the discovery isolation of bio-active compounds have unveils main ingredients, such quercetin, kinsenoside rhamnazin. Pharmacological studies further demonstrated its activities, containing anti-inflammation, anti-oxidation, antihyperlipidemia effects. The processed products commercial applications functional foods cosmetics. prepare soup, drinkbeverage, jelly, face masks, soap, etc. However, despite abundant value, it hasn't included 2020 Pharmacopoeia up now. There also no consistent evaluation standard across provinces. This seriously affects safety efficacy TCM prescriptions, not mention development question. review summarizes recent research on phytochemistry, pharmacology, quality control applications, raises corresponding solutions provide references potential directions for studies.

Language: Английский

Citations

0
Identification and Functional Characterization of Two UDP-Glycosyltransferases Involved in Narcissoside Biosynthesis in Anoectochilus roxburghii DOI
Xuhui He, Hongrui Wang, Mingyue Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Flavonoid rutinosides, a group of bioactive compounds in Anoectochilus roxburghii, contribute greatly to the plant's beneficial effects on human health. However, glycosylation mechanism flavonoid rutinosides A. roxburghii remains unclear. In this study, two efficient and selective glycosyltransferases, AUTG25 AUTG23, involved biosynthesis narcissoside, major rutinoside were identified through transcriptome analysis functional validation. could regioselectively catalyze 3-O-glucosylation isorhamnetin produce 3-O-glucoside, while AUTG23 further 6"-O-rhamnosylation generate narcissoside. Both exhibited high positional sugar donor selectivities catalytic reaction. Homology modeling site-directed mutagenesis showed that H20, E83, E385, F143 E280, E89, D188, W327, D369, Y191 may be critical for their functions. Transient expression Nicotiana benthamiana finally confirmed possesses flavonol-3-O-glucosyltransferase activity has flavonol-3-O-glucoside (1→6) rhamnosyltransferase activity. This study clarified provided candidate UDP-dependent glycosyltransferase genes narcissoside roxburghii.

Language: Английский

Citations

0
Kinsenoside attenuates ER stress and inhibits inflammatory responses through IL-10/STAT/SOCS3 pathway in chronic pain relief DOI
Wei Wang,

Yingzhuo Ding,

Chunxia Yu

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110463 - 110463

Published: April 1, 2025

Language: Английский

Citations

0
Verification of the chromosome number using cytogenetics and estimation of genome size via flow cytometry and k-mer analyses for representative Anoectochilus roxburghii accessions DOI Creative Commons
Wenting Zhang,

Yu Mei,

Jihua Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0322457 - e0322457

Published: May 28, 2025

Anoectochilus roxburghii (Wall.) Lindl. is a perennial herb of orchidaceae. Because its functions heat-clearing and blood-cooling, removing dampness, detoxification enhancing immunity, it considered as nutritious medicinal plant with high economic value. Originating from Guangdong province, China, chromosome number genome size A. (“Luofushan-1”) were determined through cytogenetics, flow cytometry, k-mer analysis. We analyzed the karyotype using different cytogenetic markers, results showed 2n = 80, but no sex-linked heterotropy was observed. For cytometry analysis, tomato maize used internal standard, 2C DNA amount among sixteen accessions ranged 6.57 to 8.26 pg (including Luofushan-1). Additionally, survey “Luofushan-1” performed Illumina HiSeq 2000 sequencing, analysis revealed that approximately 5.68 Gbp. This comprehensive study establishes foundation for subsequent whole-genome sequencing roxburghii, contributing valuable insights into genetic characteristics paving way further research on this plant.

Language: Английский

Citations

0
Therapeutic targets in alcohol-associated liver disease: progress and challenges DOI Creative Commons
Ayooluwatomiwa D. Adekunle, Adeyinka Adejumo, Ashwani K. Singal

et al.

Therapeutic Advances in Gastroenterology, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Alcohol-associated liver disease (ALD) is a complex with rapidly increasing prevalence. Although there are promising therapeutic targets on the horizon, none of newer currently close to an Food and Drug Administration approval. Strategies needed overcome challenges in study designs conducting clinical trials provide impetus field drug development landscape ALD alcoholic hepatitis. Management should include therapies achieve maintain alcohol abstinence, preferably delivered by multidisciplinary team. associated clear mortality benefit select patients, use early transplantation still requires refinement create uniformity selection protocols across transplant centers. There also need for reliable noninvasive biomarkers prognostication. Last but not least, strategies urgently implement integrated care models treating dual pathology disorder improving long-term outcomes patients ALD.

Language: Английский

Citations

6
The Toxicological Assessment of Anoectochilus burmannicus Ethanolic-Extract-Synthesized Selenium Nanoparticles Using Cell Culture, Bacteria, and Drosophila melanogaster as Suitable Models DOI Creative Commons
Pensiri Buacheen, Jirarat Karinchai, Woorawee Inthachat

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(20), P. 2804 - 2804

Published: Oct. 22, 2023

Selenium nanoparticles (SeNPs) are worthy of attention and development for nutritional supplementation due to their health benefits in both animals humans with low toxicity, improved bioavailability, controlled release, being greater than the Se inorganic organic forms. Our previous study reported that Anoectochilus burmannicus extract (ABE)-synthesized SeNPs (ABE-SeNPs) exerted antioxidant anti-inflammatory activities. Furthermore, ABE could stabilize preserve biological activities SeNPs. To promote ABE-SeNPs as supplementary functional foods, it was necessary carry out a safety assessment. Cytotoxicity testing showed were harmless no killing effect on Caco2 (intestinal epithelial cells), MRC-5 (lung fibroblasts), HEK293 (kidney LX-2 (hepatic stellate 3T3-L1 (adipocytes), not toxic isolated human PBMCs RBCs. Genotoxicity assessments found did induce mutations Salmonella typhimurium TA98 TA100 (Ames test) well Drosophila melanogaster (somatic mutation recombination test). Noticeably, inhibited induced by AF-2, urethane, ethyl methanesulfonate, mitomycin c, suggesting anti-mutagenicity ability. This provides data support anti-genotoxicity properties further SeNPs-based food supplements.

Language: Английский

Citations

6