Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 314, P. 116662 - 116662

Published: May 18, 2023

Language: Английский

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From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8333 - 8333

Published: May 5, 2023

Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic agents. However, existing research mechanism silica-dust-induced fibrosis is only tip iceberg and lags far behind clinical needs. Idiopathic (IPF), as disease, also has same In this study, we examined relationship between IPF from perspective their fibrotic characteristics, further discussing current drug limitations application silicosis. Overall, review provided novel insights for treatment with hope bridging gap practice

Language: Английский

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Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118264 - 118264

Published: April 29, 2024

Language: Английский

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Traditional Chinese medicine inspired dual-drugs loaded inhalable nano-therapeutics alleviated idiopathic pulmonary fibrosis by targeting early inflammation and late fibrosis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Idiopathic pulmonary fibrosis (IPF) is a highly debilitating and fatal chronic lung disease that difficult to cure clinically. IPF characterized by gradual decline in function, which leads respiratory failure severely affects patient quality of life survival. Oxidative stress inflammation are believed be important pathological mechanisms underlying the onset progression IPF, vicious cycle NOX4-derived ROS, NLRP3 inflammasome activation, p38 MAPK fibrogenesis explains ineffectiveness single-target or single-drug interventions. In this study, we combined astragaloside IV (AS-IV) ligustrazine (LIG) based on fundamental theory traditional Chinese medicine (TCM) “tonifying qi activating blood” loaded these drugs onto nanoparticles (AS_LIG@PPGC NPs) were inhalable could penetrate mucosal barrier. Our results suggested inhalation AS_LIG@PPGC NPs significantly improved bleomycin-induced injury regulating NOX4-ROS-p38 NOX4-NLRP3 pathways treat prevent IPF. This study not only demonstrated superiority, feasibility, safety therapy for intervention but also confirmed breaking ROS promising strategy successful treatment Moreover, nanoplatform good example integration TCM modern medicine.

Language: Английский

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Astragalus saponins protect against extrahepatic and intrahepatic cholestatic liver fibrosis models by activation of farnesoid X receptor

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116833 - 116833

Published: July 1, 2023

Language: Английский

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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 15, 2025

Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory anti-tumor properties. In this study, HK2 cells rat model were utilized explore protective effect AS-IV against cadmium chloride-induced oxidative stress-induced apoptosis. CdCl2-induced apoptosis, ROS production, mitochondrial membrane potential alterations significantly inhibited in -treated cells. Expression mitochondria-associated apoptotic proteins Cleaved-Caspase3, Cleaved-Caspase9, Cleaved-PARP was reduced after intervention. addition, Rat weight loss also alleviated symptoms nephrotoxicity injury. Further experiments showed that suppresses heavy metal Cd-induced mitochondria-mediated apoptosis by regulating Nrf2/HO-1 pathway. conclusion, could protect metal-induced toxicity be used as nephroprotective agent.

Language: Английский

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Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Background Peritoneal fibrosis (PF) causes peritoneal dialysis (PD) withdrawal due to ultrafiltration failure. Qixue Huazheng formula (QXHZF), comprising Astragalus membranaceus , Centella asiatica and Ligusticum sinense is applied treat PD-related peritoneum injury related; however, the active components, core genes, underlying mechanism involved remain unclear. Methods The anti-PF effects of QXHZF were verified in vivo vitro . Targets QXHZF-mediated improvement PD-induced PF predicted using network pharmacology analysis. Metabolites associated with treatment analyzed by serum metabolomics. Integration metabolomics findings identified potentially important pathways, metabolites, targets, molecular docking studies confirmed interactions key components targets. Western blotting (WB), quantitative real-time PCR (qRT-PCR), TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, flow cytometry conducted. Results had potent therapeutic efficacy against according WB, qRT-PCR, pathological section examination. Network pharmacological analysis indicated that multiple compounds contributed improving modulating various targets pathways. Differential metabolites Integrated data steroid hormone biosynthesis, Ras signaling pathway, apoptosis, estrogen QXHZF. Metabolite-target analyses revealed can bind receptor 1 (ESR1) rapidly accelerated fibrosarcoma (RAF1) through its components. WB demonstrated reversed activation above-mentioned thereby inhibiting PD fluid-induced PF. Conclusion significantly ameliorate may regulate signaling, apoptosis this context.

Language: Английский

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Astragalus mongholicusbunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Introduction Astragalus mongholicus bunge and Angelica sinensis are botanical drugs rich in beneficial nutrients health-promoting metabolites. Their roots can be decocted to a drug decoction “Danggui Buxue Tang (DBT),” demonstrating human anti-inflammatory Methods Here, we evaluate the mitigating function of DBT on lung inflammation early fibrosis rat model. The model was established by tracheal dripping silica suspension for 28 days. Positive intervention effects were observed dose-dependent manner after consecutive gavage (1.9, 3.8, 7.6 g/kg·bw/d) days 42 To explore underlying molecular mechanism. metabolites profiled using liquid chromatograph-mass spectrometer Chemspider database. Results Lung confirmed functional tests histopathologic analysis. Metabolite target analysis identified nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) as key regulating pulmonary fibrosis. Gene ontology (GO) estimated that oxidative stress, inflammatory response, myofibroblast differentiation, extracellular matrix (ECM) deposition major pathways DBT. KEGG found might modulate through transforming growth factor-β (TGF-β) pathway. GO chord signaling pathway maps revealed NOX4 contributes TGF-β regulation. vivo analyses significantly reduces protein expression, inhibits stress responses, TGF-β1, p-SMAD3, fibronectin 1 (FN1), smooth muscle actin (α-SMA) expression. Discussion These findings demonstrate lung-protecting identify critical proteins associated with

Language: Английский

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Luteolin mitigates renal ischemia-reperfusion injury via anti-inflammatory, anti-apoptotic, and Nrf2/HO-1-mediated antioxidant effects: a network pharmacology and experimental study

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177676 - 177676

Published: April 1, 2025

Language: Английский

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Treatment of peritoneal fibrosis: Therapeutic prospects of bioactive Agents from Astragalus membranaceus

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 15, 2024

Peritoneal dialysis is one of the renal replacement treatments for patients with end-stage disease. dialysis-related peritoneal fibrosis a pathological change in tissue progressive, non-suppurative inflammation accompanied by fibrous hyperplasia, resulting damage to original structure and function, leading function failure. Currently, there no specific drug clinic. Therefore, it necessary find good effects few adverse reactions. Astragalus membranaceus (AMS) dried root

Language: Английский

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