The role of long noncoding RNA MEG3 in fibrosis diseases DOI
Wenlong Wu,

Sijing Zhou,

Guanghe Fei

et al.

Postgraduate Medical Journal, Journal Year: 2023, Volume and Issue: 100(1186), P. 529 - 538

Published: Dec. 8, 2023

Fibrosis is a prevalent pathological condition observed in various organs and tissues. It primarily arises from the excessive abnormal accumulation of extracellular matrix, resulting structural functional impairment tissues organs, which can culminate death. Many forms fibrosis, including liver, cardiac, pulmonary, renal are considered irreversible. Maternally expressed gene 3 (MEG3) an imprinted RNA gene. Historically, downregulation MEG3 has been linked to tumor pathogenesis. However, recent studies indicate emerging association with fibrotic diseases. In this review, we delve into current understanding MEG3's role aiming shed light on molecular mechanisms fibrosis potential as novel therapeutic target.

Language: Английский

Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer DOI

S. Chandel,

Anurag Mishra, Gaurav Dubey

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155156 - 155156

Published: Jan. 26, 2024

Language: Английский

Citations

1
LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic Heart Development DOI Open Access
Xiangqi Teng,

Hongjuan He,

Haoran Yu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8184 - 8184

Published: July 26, 2024

The

Language: Английский

Citations

1
An update: epigenetic mechanisms underlying methamphetamine addiction DOI Creative Commons

Mingxin Liu,

Zizhen Si

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 22, 2024

Methamphetamine (METH) is one of the most widely abused illicit drugs globally. Despite its widespread abuse, effects methamphetamine on brain and precise mechanisms underlying addiction remain poorly understood. Elucidating these biological developing effective treatments utmost importance. Researchers have adopted a multi-faceted approach, combining studies at genetic, molecular, organ, individual levels, to explore epigenetic changes that use brings an organism from both micro macro perspectives. They utilize comparative analysis experimental animal data clinical cases ascertain differences identify potential targets for translating METH research setting. Recent demonstrated regulation plays pivotal role in neural mechanisms, encompassing DNA methylation, histone modifications (such as acetylation methylation), ubiquitination, phosphorylation, non-coding RNA. These factors influence individual’s susceptibility response by regulating expression specific genes. Specifically, has been observed cause alterations methylation status, which turn affects genes associated with neuroreward pathways, leading function structure. Furthermore, significant implications neurotoxicity addiction. For instance, H3 modify chromatin structure, consequently influencing transcriptional activity Non-coding RNAs, including microRNAs (miRNAs) long RNAs (lncRNAs), also play interacting messenger (mRNAs) gene expression. To further advance our understanding, researchers employ advanced technologies such high-throughput sequencing, immunoprecipitation sequencing (ChIP-seq), RNA (RNA-seq) comprehensively analyze models human subjects. enable markers their functional consequences. This article reviews discusses future treatment strategies, particularly development targeting By deepening comprehension regulatory it anticipated targeted therapeutic strategies may be devised reverse addiction, thus enhancing efficacy paving way this domain.

Language: Английский

Citations

1
Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis DOI Open Access
Basavaraj Vastrad, Chanabasayya Vastrad

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 29, 2023

Abstract Schizophrenia is thought to be the most prevalent chronic psychiatric disorder. Numerous proteins have been identified that are associated with occurrence and development of schizophrenia. This study aimed identify potential core genes pathways involved in schizophrenia, through exhaustive bioinformatic next generation sequencing (NGS) data analyses using GSE20966 NGS neural progenitor cells neurons obtained from healthy controls patients The were downloaded Gene Expression Omnibus database. was processed by DESeq2 package R software differentially expressed (DEGs) identified. Ontology (GO) enrichment analysis REACTOME pathway carried out biological functions DEGs. Protein-protein interaction (PPI) network, module, miRNA-hub gene regulatory network TF-hub performed hub genes, miRNA TFs. Potential analyzed receiver operating characteristic (ROC) curves (pROC). In this investigation, an overall 955 DEGs identified: 478 remarkably up regulated 477 distinctly down regulated. These enriched for GO terms mainly multicellular organismal process, GPCR ligand binding, regulation cellular process amine ligand-binding receptors. MYC, FN1, CDKN2A, EEF1G, CAV1, ONECUT1, SYK, MAPK13, TFAP2A BTK considered genes. constructed successfully. On whole, findings investigation enhance our understanding molecular mechanisms schizophrenia provide targets further investigation.

Language: Английский

Citations

2
Long noncoding RNA MEG3: an active player in fibrosis DOI
Xiaoying Jiang

Pharmacological Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

0
MicroRNAs and angiosarcoma: are there promising reports? DOI Creative Commons
Amir Modarresi Chahardehi, Arya Afrooghe,

Nikoo Emtiazi

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 17, 2024

In recent years, microRNAs (miRNAs) have garnered increasing attention for their potential implications in cancer pathogenesis, functioning either as oncogenes or tumor suppressors. Notably, angiosarcoma, along with various other cardiovascular tumors such lipomas, rhabdomyomas, hemangiomas, and myxomas, has shown variations the expression of specific miRNA subtypes. A substantial body evidence underscores pivotal involvement miRNAs genesis angiosarcoma certain tumors. This review aims to delve into current literature on prospective applications malignancies, a focus angiosarcoma. It comprehensively covers diagnostic methods, prognostic evaluations, treatments while providing recapitulation angiosarcoma’s risk factors molecular an emphasis role miRNAs. These insights can serve groundwork designing randomized control trials, ultimately facilitating translation these findings clinical applications. Moving forward, it is imperative studies thoroughly scrutinize advantages disadvantages compared approaches Closing knowledge gaps will be crucial harnessing full realm research.

Language: Английский

Citations

0
Correlations between the long noncoding RNA MEG3 and clinical characteristics for diabetic kidney disease in type 2 diabetes mellitus DOI Creative Commons
Ke-Hsin Ting, Po-Jen Yang,

Po-Yu Tsai

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 1, 2024

Diabetic kidney disease (DKD) is a common complication of type 2 diabetes mellitus (T2DM) that leads to systemic inflammation. Maternally expressed gene 3 (MEG3) tumor suppressor involved in inflammation regulation. The current study investigated the association between DKD and prevalence single-nucleotide polymorphisms (SNPs) MEG3.

Language: Английский

Citations

0
Screening of the key genes and signaling pathways for schizophrenia using bioinformatics and next generation sequencing data analysis DOI Creative Commons
Iranna Kotturshetti, Basavaraj Vastrad,

Veena Kori

et al.

Italian Journal of Medicine, Journal Year: 2024, Volume and Issue: 18(4)

Published: Dec. 18, 2024

Schizophrenia is thought to be the most prevalent chronic psychiatric disorder. Researchers have identified numerous proteins associated with occurrence and development of schizophrenia. This study aimed identify potential core genes pathways involved in schizophrenia through exhaustive bioinformatics next generation sequencing (NGS) data analyses using GSE106589 NGS neural progenitor cells neurons obtained from healthy controls patients The were downloaded Gene Expression Omnibus database. was processed by DESeq2 package R software, differentially expressed (DEGs) identified. ontology (GO) enrichment analysis REACTOME pathway carried out biological functions DEGs. Protein-protein interaction network, module, micro-RNA (miRNA)-hub gene regulatory transcription factor (TF)-hub drug-hub network performed hub genes, miRNA, TFs, drug molecules. Potential analyzed receiver operating characteristic curves package. In this investigation, an overall 955 DEGs identified: 478 remarkably upregulated 477 distinctly downregulated. These enriched for GO terms mainly multicellular organismal process, G protein-coupled receptor ligand binding, regulation cellular processes, amine ligand-binding receptors. MYC, FN1, CDKN2A, EEF1G, CAV1, ONECUT1, SYK, MAPK13, TFAP2A, BTK considered genes. MiRNA-hub TF-hub constructed successfully predicted key miRNAs, molecules diagnosis treatment. On whole, findings investigation enhance our understanding molecular mechanisms provide targets further investigation.

Language: Английский

Citations

0
The role of long noncoding RNA MEG3 in fibrosis diseases DOI
Wenlong Wu,

Sijing Zhou,

Guanghe Fei

et al.

Postgraduate Medical Journal, Journal Year: 2023, Volume and Issue: 100(1186), P. 529 - 538

Published: Dec. 8, 2023

Fibrosis is a prevalent pathological condition observed in various organs and tissues. It primarily arises from the excessive abnormal accumulation of extracellular matrix, resulting structural functional impairment tissues organs, which can culminate death. Many forms fibrosis, including liver, cardiac, pulmonary, renal are considered irreversible. Maternally expressed gene 3 (MEG3) an imprinted RNA gene. Historically, downregulation MEG3 has been linked to tumor pathogenesis. However, recent studies indicate emerging association with fibrotic diseases. In this review, we delve into current understanding MEG3's role aiming shed light on molecular mechanisms fibrosis potential as novel therapeutic target.

Language: Английский

Citations

0