Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Background
Serum
vitamin
B12
and
α-Klotho
are
important
markers
associated
with
aging.
Limited
studies
have
been
conducted
on
the
relationship
between
α-Klotho.
Objectives
This
study
investigated
circulating
B12.
Methods
A
total
of
4,502
American
adults
levels
from
National
Health
Nutrition
Examination
Survey
(2011–2014)
were
included.
weighted
multiple
linear
regression
model
was
used
to
evaluate
correlation
levels.
To
clarify
potential
non-linearities,
smoothed
curve
fitting
threshold
effects
analysis
employed.
Results
statistically
significant
non-linear
found
after
adjusting
for
confounders.
We
observed
an
inverted
U-shaped
serum
Notably,
below
(1,020
pg/mL)
exhibited
a
positive
(
β
=
0.14,
95%
confidence
interval
(CI):
0.09–0.18,
p
<
0.0001).
Conversely,
above
negative
−0.12,95%
CI:
−0.17−−0.06,
Sensitivity
analyses
performed
consistent
results
obtained.
Conclusion
demonstrated
in
adults.
The
optimal
concentration
found.
Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1867 - 1878
Published: April 1, 2024
Abstract:
Atherosclerosis
is
one
of
the
most
dominant
pathological
processes
responsible
in
cardiovascular
diseases
(CVD)
caused
by
cholesterol
accumulation
accompanied
inflammation
arteries
which
will
subsequently
lead
to
further
complications,
including
myocardial
infarction
and
stroke.
Although
incidence
atherosclerosis
decreasing
some
countries,
it
still
considered
leading
cause
death
worldwide.
a
vascular
process
that
chronically
inflammatory
characterized
invasion
cells
cytokines.
Many
reports
have
unraveled
pivotal
roles
epigenetics
such
as
DNA
methylation,
post-translational
histone
modifications,
non-coding
RNAs
(ncRNAs)
atherogenesis,
regulate
expression
numerous
genes
related
various
pathways.
studies
been
conducted
develop
new
therapeutical
approaches
based
on
epigenetic
changes
for
combating
atherosclerosis.
This
review
elaborates
recent
updates
development
drugs
whose
mechanism
action
associated
with
modulation
posttranslational
ncRNA-based
gene
regulation.
Keywords:
atherosclerosis,
RNAs,
pharmacotherapy
Current Vascular Pharmacology,
Journal Year:
2023,
Volume and Issue:
21(3), P. 185 - 196
Published: May 1, 2023
Abstract:
Cardiometabolic
diseases,
such
as
type
2
diabetes
mellitus
(DM)
and
cardiovascular
disease
(CVD),
are
a
great
health
concern.
The
strategies
aimed
to
increase
awareness
prevention,
in
conjunction
with
timely
diagnosis
optimal
management
of
these
conditions,
represent
the
main
lines
action
improve
life
expectancy
quality.
In
recent
years,
introduction
innovative
therapies
for
treatment
DM
CVD
has
provided
new
hope
high-risk
patients.
Yet,
implementation
preventive
measures
achieving
cardiometabolic
is
far
from
successful
requires
further
improvement.
development
disorders
complex,
multifactorial
process
involving
several
metabolic
pathways
well
genetic
environmental
factors.
Decreasing
cumulative
exposure
during
entire
course
recognition
targeting
potential
riskenhancing
factors
could
pave
way
toward
more
prevention
disorders.
Nowadays,
era
“omics”
technologies,
it
possible
identify
novel
biomarkers
therapeutic
targets,
which
offers
possibility
apply
an
individualized
approach
each
patient.
This
review
will
discuss
applications
genomic,
transcriptomic,
epigenetic
metabolomic
personalized
diseases.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2023,
Volume and Issue:
55(8), P. 1184 - 1192
Published: March 31, 2023
Autophagy
plays
a
critical
role
in
the
physiology
and
pathophysiology
of
hepatocytes.
High
level
homocysteine
(Hcy)
promotes
autophagy
hepatocytes,
but
underlying
mechanism
is
still
unknown.
Here,
we
investigate
relationship
between
Hcy-induced
expression
nuclear
transcription
factor
EB
(TFEB).
The
results
show
that
mediated
by
upregulation
TFEB.
Silencing
TFEB
decreases
autophagy-related
protein
LC3BII/I
increases
p62
hepatocytes
after
exposure
to
Hcy.
Moreover,
effect
Hcy
on
regulated
hypomethylation
promoter
catalyzed
DNA
methyltransferase
3b
(DNMT3b).
In
summary,
this
study
shows
can
activate
inhibiting
DNMT3b-mediated
methylation
upregulating
expression.
These
findings
provide
another
new
for
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 11, 2024
Abstract
Sequencing
the
DNA
nucleobases
is
essential
in
diagnosis
and
treatment
of
many
diseases
related
to
human
genes.
In
this
article,
encapsulation
with
some
important
synthesized
chiral
(7,
6),
(8,
(10,
8)
carbon
nanotubes
were
investigated.
The
structures
modeled
by
applying
density
functional
theory
based
on
tight
binding
method
(DFTB)
considering
semi-empirical
basis
sets.
Encapsulating
inside
CNTs
caused
changes
electronic
properties
selected
CNTs.
results
confirmed
that
van
der
Waals
(vdW)
interactions,
π-orbitals
non-bonded
electron
pairs,
presence
high
electronegative
atoms
are
key
factors
for
these
changes.
result
parameters
showed
among
CNTs,
CNT
6)
a
suitable
choice
sequencing
guanine
(G)
cytosine
(C)
nucleobases.
However,
they
not
able
sequence
adenine
(A)
thymine
(T).
According
band
gap
energy
engineering
approach
absorption
energy,
G
C
decreased
Hence
suggested
as
biosensor
substrates
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117244 - 117244
Published: Aug. 9, 2024
Atherosclerosis,
the
leading
cause
of
cardiovascular
disease,
cannot
be
sufficiently
explained
by
established
risk
factors,
including
cholesterol.
Elevated
plasma
homocysteine
(Hcy)
is
an
independent
factor
for
atherosclerosis
and
closely
linked
to
mortality.
However,
its
role
in
has
not
been
fully
clarified
yet.
We
have
previously
shown
that
rabbits
fed
a
diet
deficient
B
vitamins
choline
(VCDD),
which
are
required
Hcy
degradation,
exhibit
accumulation
macrophages
lipids
aorta,
aortic
stiffening
disorganization
collagen
absence
hypercholesterolemia,
aggravation
presence.
In
current
study,
levels
were
increased
intravenous
injections
into
balloon-injured
VCDD
(VCDD+Hcy)
hypercholesterolemia.
While
this
treatment
did
lead
thickening
wall,
led
massive
VLDL-triglycerides
as
well
significant
impairment
vascular
reactivity
aorta
compared
alone.
VCDD-fed
fragmentation
elastin,
elastin-specific
electron-dense
inclusions,
disorganization,
lipid
autophagolysosome
formation.
Furthermore,
from
VCDD+Hcy
group
exhibited
decrease
total
protein
methylated
arginine
blood
cells
decreased
creatine
cells,
serum
liver
group.
Altogether,
we
conclude
contributes
atherogenic
transformation
only
presence
but
also
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 42 - 42
Published: Dec. 27, 2024
Biomarkers
constitute
a
valuable
tool
to
diagnose
both
the
incidence
and
prevalence
of
chronic
diseases
may
help
inform
design
effectiveness
precision
nutrition
interventions.
Cardiovascular
disease
(CVD)
continues
be
foremost
cause
death
all
over
world.
While
reasons
that
lead
increased
risk
for
CVD
are
multifactorial,
dyslipidemias,
plasma
concentrations
specific
lipoproteins,
dynamic
measures
lipoprotein
function
strong
biomarkers
predict
document
coronary
heart
incidence.
The
aim
this
review
is
provide
comprehensive
evaluation
emerging
approaches
can
utilized
characterize
profiles
as
predictive
tools
assessing
risk,
including
assessment
traditional
clinical
lipid
panels,
efflux
capacity
inflammatory
antioxidant
activity,
omics-based
characterization
composition
regulators
metabolism.
In
addition,
we
discuss
demographic,
genetic,
metagenomic,
lifestyle
determinants
profiles—such
age,
sex,
gene
variants
single-nucleotide
polymorphisms,
gut
microbiome
profiles,
dietary
patterns,
physical
inactivity,
obesity
status,
smoking
alcohol
intake,
stress—which
likely
essential
factors
explain
interindividual
responses
recommendations
mitigate
risk.
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 127 - 127
Published: Dec. 31, 2024
Atherosclerosis
is
a
chronic
inflammatory
disease
developing
and
progressing
in
the
presence
of
risk
factors
including
hyperlipidemia,
hypercholesterolemia,
inflammation,
among
others.
commonly
precipitates
as
ischemic
events,
transient
attacks,
myocardial
infarction.
Saturated
fatty
acids
are
factors;
however,
their
association
with
epigenetics
pathophysiology
atherosclerosis
not
clearly
understood.
The
preclinical
clinical
trials
associating
scarcely
documented,
most
studies
reported
use
drugs
inhibiting
methylation
histone
modification
to
improve
atherosclerosis.
This
narrative
review
aims
discuss
various
aspects
between
high-fat
diet,
epigenetic
reprogramming,
A
literature
search
keywords
epigenetics,
atherosclerosis,
alone
or
combination,
was
conducted
for
articles
English
language.
Duplicate
were
removed,
related
subject
this
article
included
review.
suggests
that
diet
saturated
factor
but
multifactorial,
play
critical
role.
However,
connecting
link
underlying
molecular
cellular
mechanisms
understood
yet
warrant
more
research.
rich
involving
reprogramming
altered
gene
expression.
existing
support
role
reversing
it
using
attenuate
definitive
evidence
warrants
larger
trials.
Further,
pregnant
mothers
can
manifest
cardiovascular
offspring;
caution
must
be
taken
nutrients.
