Deleted Journal, Journal Year: 2024, Volume and Issue: 29(2), P. 111 - 131
Published: May 1, 2024
Language: Английский
Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4907 - 4907
Published: Nov. 20, 2022
Active vitamin D [1,25(OH)2D3—calcitriol] is a secosteroid hormone whose receptor expressed on all cells of the immune system. Vitamin has global anti-inflammatory effect and its role in management SARS-CoV-2 infection been investigated since beginning COVID-19 pandemic. In this narrative review, laboratory clinical results supplementation have collected from both open-label blinded randomized trials. The are generally favor utility maintaining serum concentrations calcifediol [25(OH)D3] at around 40 ng/mL absolute usefulness subjects with deficient levels. However, two very recent large-scale studies (one open-label, one placebo-controlled) called into question contribution to practice era vaccinations. precise anti-COVID-19 armamentarium requires further investigations light breakthrough which achieved mass
Language: Английский
Citations
15
Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1277 - 1277
Published: April 25, 2023
Vitamin D and its role in the coronavirus-19 disease (COVID-19) pandemic has been controversially discussed, with inconclusive evidence about vitamin D3 (cholecalciferol) supplementation COVID-19 patients. metabolites play an important initiation of immune response can be easily modifiable risk factor 25-hydroxyvitamin (25(OH)D3)-deficient This is a multicenter, randomized, placebo-controlled double-blind trial to compare effect single high dose followed by treatment as usual (TAU) daily until discharge versus placebo plus TAU hospitalized patients 25(OH)D3-deficiency on length hospital stay. We included 40 per group did not observe significant difference median stay (6 days both groups, p = 0.920). adjusted for factors (β 0.44; 95% CI: -2.17-2.22), center 0.74; -1.25-2.73). The subgroup analysis severe (<25 nmol/L) showed non-significant reduction intervention (5.5 vs. 9 days, 0.299). competing model death reveal differences between (HR 0.96, CI 0.62-1.48, 0.850). Serum 25(OH)D3 level increased significantly (mean change nmol/L; intervention: +26.35 control: -2.73, < 0.001). 140,000 IU + shorten but was effective safe elevation serum levels.
Language: Английский
Citations
8
Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 831 - 831
Published: Oct. 16, 2024
The interaction of the SARS-CoV-2 spike protein with membrane-bound angiotensin-converting enzyme-2 (ACE-2) receptors in epithelial cells facilitates viral entry into human cells. Despite this, ACE-2 exerts significant protective effects against coronaviruses by neutralizing viruses circulation and mitigating inflammation. While reduces expression, vitamin D increases it, counteracting virus's harmful effects. Vitamin D's beneficial actions are mediated through complex molecular mechanisms involving innate adaptive immune systems. Meanwhile, status [25(OH)D concentration] is inversely correlated severity, complications, mortality rates from COVID-19. This study explores which inhibits replication, including suppression transcription enzymes, reduced inflammation oxidative stress, increased expression antibodies antimicrobial peptides. Both hypovitaminosis elevate renin levels, rate-limiting step renin-angiotensin-aldosterone system (RAS); it ACE-1 but expression. imbalance leads to elevated levels pro-inflammatory, pro-coagulatory, vasoconstricting peptide angiotensin-II (Ang-II), leading widespread It also causes membrane permeability, allowing fluid infiltrate soft tissues, lungs, vascular system. In contrast, sufficient suppress reducing RAS activity, lowering ACE-1, increasing levels. cleaves Ang-II generate Ang
Language: Английский
Citations
3
Hipertensión y Riesgo Vascular, Journal Year: 2024, Volume and Issue: 41(3), P. 145 - 153
Published: June 12, 2024
Citations
2
Pharmacology Research & Perspectives, Journal Year: 2024, Volume and Issue: 12(5)
Published: Sept. 30, 2024
Abstract The COVID‐19 pandemic has emerged as a major global health crisis. Vitamin D, crucial fat‐soluble vitamin, been recommended for patients, though evidence of its effectiveness is inconsistent. This systematic literature review and meta‐analysis aimed to evaluate the impact vitamin D supplementation on COVID‐19‐related outcomes. A comprehensive search was conducted across PubMed, Scopus, Web Science, Embase, Cochrane databases. Primary outcomes included mortality hospital length stay, while secondary encompassed C‐reactive protein (CRP), ferritin, D‐dimer, hemoglobin (Hb) concentrations, lymphocyte, neutrophil, platelet counts. Data analysis performed using Stata™ Version 14. total 16 trials were analyzed. revealed that significantly reduced stay (mean difference = −1.16; 95% confidence interval [CI]: −2.23, −0.09; p .033) with significant heterogeneity ( I 2 69.2%, .002). Subgroup showed more pronounced reduction in studies dosages ≤10 000 international units (IU) −1.27; CI: −1.96, −0.57; < .001) patients over 60 years old −1.84; −2.53, −1.14; .001). Additionally, CRP concentrations older adults (>60 years) −1.13; −2.07, −0.18; .019). No changes found Hb or counts > .05). In conclusion, did not affect most biomarkers, however, it reduces stay.
Language: Английский
Citations
2
Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 620 - 620
Published: Nov. 13, 2024
Objectives: Identifying reliable biomarkers to predict mortality in critically ill patients is crucial for optimizing management intensive care units (ICUs). Inflammatory and metabolic markers are increasingly recognized their prognostic value. This study aims evaluate the association of various inflammatory with ICU mortality. Methods: prospective observational was conducted from January 2023 2024 City Hospital’s ICU. A total 160 were enrolled. Laboratory parameters, including white blood cell (WBC) count, red distribution width (RDW), platelet neutrophil mean volume (MPV), monocyte lymphocyte procalcitonin (PCT), C-reactive protein (CRP), calcium (Ca++), vitamin D levels, analyzed. Additionally, ratios such as platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), systemic index (SII), pan-immune-inflammation value (PIV) calculated. Plasma levels Gla-rich (GRP) dephosphorylated uncarboxylated matrix Gla (dp-ucMGP) measured using ELISA. Results: The age included 60.5 ± 15.8 years. Cardiovascular disease present 72 (45%), respiratory system 58 (36%), chronic kidney (CKD) 38 (24%). 61 (38%) had diabetes, 68 (42%) hypertension. markers, PLR, NLR, PIV, all significantly higher non-survivors, while lower (p < 0.05). Higher WBC, RDW, CRP, procalcitonin, GRP, dp-ucMGP positively correlated longer hospital stays increased In contrast, counts negatively both outcomes Vitamin showed an inverse relationship stay mortality, indicating that associated worse multiple logistic regression analysis, elevated WBC count (OR = 1.20, p 0.02), RDW 1.35, 0.01), 1.25, MPV PLR 1.30, NLR 1.40, 0.001), PIV 1.50, CRP 1.32, 1.45, GRP 0.001) Conclusions: particularly dp-ucMGP, strong predictors patients. These provide valuable insights risk stratification early identification high-risk patients, potentially guiding more targeted interventions improve outcomes.
Language: Английский
Citations
2
Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(3), P. 1808 - 1817
Published: Dec. 7, 2023
Abstract The efficacy of administering high doses vitamin D to patients diagnosed with COVID‐19 remains uncertain. We conducted a comprehensive search across multiple databases (PubMed, EMBASE, Cochrane Library, and ISI Web Science) from inception until August 2022, no limitations on language, locate randomized controlled trials (RCTs) that investigated the impact high‐dose supplementation (defined as single dose ≥100,000 IU or daily ≥10,000 reaching total IU) patients. Risk ratios (RR) 95% confidence intervals (CI) weighted mean differences (WMD) CI were calculated. Our meta‐analysis included 5 RCTs 834 High‐dose did not show any significant benefits for mortality ( I 2 = 0.0%, p .670; RR 1.092, 0.685–1.742, .711) intensive care unit (ICU) admission .519; 0.707, 0.454–1.102, .126) in compared control group. However, it was found be safe well‐tolerated .887; 1.218, 0.930–1.594, .151). Subgroup analysis also showed overall mortality, including deficiency .452; 2.441, 0.448–13.312, .303) placebo .673; 1.666, 0.711–3.902, .240). research indicates there is evidence support improving clinical outcomes among individuals COVID‐19, line previous studies focused contexts rickets. Considering study, additional may required.
Language: Английский
Citations
6
Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3794 - 3794
Published: Nov. 5, 2024
Vitamin D's role in COVID-19 management remains controversial. This meta-analysis aimed to evaluate the efficacy of vitamin D supplementation patients with SARS-CoV-2 infection, focusing on mortality, intensive care unit (ICU) admissions, intubation rates, and hospital length stay (LOS).
Language: Английский
Citations
1
Published: April 27, 2024
Abstract Background Randomised trials conducted before 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, these health benefits were not confirmed by larger randomised published after 2021. Objective To examine the characteristics of on VDS patients admission intensive care unit (ICU), for prevention ARI. Method A systematic search retrieved ICU. Data ARI extracted from meta-analysis Jolliffe et al., The associations between vs no VDS, ICU evaluated using random effect models. Meta-analyses done all groups trial size. Publication bias assessed LFK index (no if -1 +1) Trim Fill method. Results Nine preventing identified. summary odds ratio (SOR) 0.61 (95%CI: 0.39-0.95) trials, 0.34 (0.13-0.93) including 50 <106 0.88 (0.62-1.24) 106 548 (effect modification: p=0.04). -3.79, Fill, SOR 0.80 (0.40-1.61). 37 0.92 (0.86-0.99) 0.69 (0.57-0.83) 25 <248 0.98 (0.94-1.03) 248 16,000 modification p=0.0001). -3.11, 0.96 (0.88-1.05). Conclusion Strong publication affected Systematic reviews should beware small-size generally exaggerate benefits.
Language: Английский
Citations
1
Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1652 - 1654
Published: Jan. 21, 2024
Language: Английский
Citations
0