IJRDO - Journal of Biological Science,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 12, 2023
Intermittent
fasting
is
a
lifestyle
intervention
that
increasingly
gaining
traction
among
the
general
population.
An
enhancement
in
rate
of
autophagy
one
fundamental
results
intermittent
fasting.
Autophagy
principal
intracellular
strategy
for
maintenance
cellular,
somatic,
and
systemic
homeostasis.
Gene-based
pharmacological
therapeutic
modalities
which
serve
to
dysregulate
stimulate
or
exacerbate
various
diseases
multiplicity
studies.
Consistently,
mutations
autophagy-related
genetic
processes
may
cause
severe
human
pathologies.
We
review
research
experimental
models
order
establish
linkage
between
dysfunction
pathogenesis
some
major
disorders,
particularly
autoimmune
disease.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
62, P. 102659 - 102659
Published: March 7, 2023
Reactive
oxygen
species
(ROS)
are
mainly
produced
in
mitochondria
and
involved
various
physiological
activities
of
the
ovary
through
signaling
critical
for
regulating
ovarian
cycle.
Notably,
imbalance
between
ROS
generation
antioxidant
defense
system
contributes
to
development
diseases.
These
contradictory
effects
have
implications
potential
strategies
that
aim
scavenge
excessive
ROS.
However,
much
remains
be
learned
about
how
causes
diseases
application
therapy
Here,
we
review
mechanisms
maintenance
homeostasis
its
associated
effects.
Additionally,
highlighted
pathological
treatment.
Genes & Diseases,
Journal Year:
2023,
Volume and Issue:
11(1), P. 148 - 175
Published: Jan. 20, 2023
Chemotherapy
is
an
effortless
and
frequently
used
approach
in
cancer
therapy.
However,
most
cases,
it
can
only
prolong
life
expectancy
does
not
guarantee
a
complete
cure.
Furthermore,
chemotherapy
associated
with
severe
adverse
effects,
one
of
the
major
complications
effective
In
addition,
newly
published
research
outputs
show
that
stem
cells
are
involved
disease
progression,
drug
resistance,
metastasis,
recurrence
they
functional
trans-differentiation
capacity
to
response
treatments.
Novel
strategies
therefore
required
for
better
management
The
prime
would
be
synthesize
develop
novel
drugs
need
extensive
resources,
time,
endurance
brought
into
therapeutic
use.
subsequent
screen
anti-cancer
activity
available
non-cancerous
drugs.
This
concept
repurposing
non-cancer
as
alternative
current
therapy
has
become
popular
recent
years
because
using
existing
anticancer
several
effects.
Micronutrients
have
also
been
investigated
due
their
significant
effects
negligible
or
no
side
availability
food
sources.
this
paper,
we
discuss
ideal
hypothesis
screening
activity,
focus
on
clinical
application
treatment.
Further,
combination
micronutrients
target
both
cancers
may
result
leading
maximum
tumor
growth
control.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(4), P. 797 - 797
Published: Feb. 4, 2023
High-grade
adult-type
diffuse
gliomas
are
the
most
common
and
deadliest
malignant
adult
tumors
of
central
nervous
system.
Despite
advancements
in
multimodality
treatment
high-grade
gliomas,
five-year
survival
rates
still
remain
poor.
The
biggest
challenge
treating
is
intra-tumor
heterogeneity
feature
glioma
tumors.
Introducing
dietary
flavonoids
to
current
strategies
crucial
overcome
this
challenge,
as
can
target
several
molecular
targets.
This
review
discusses
anticancer
mechanism
(quercetin,
rutin,
chrysin,
apigenin,
naringenin,
silibinin,
EGCG,
genistein,
biochanin
A
C3G)
through
targeting
molecules
associated
with
cell
proliferation,
apoptosis,
oxidative
stress,
cycle
arrest,
migration,
invasion,
autophagy
DNA
repair.
In
addition,
targeted
by
such
Bax,
Bcl-2,
MMP-2,
MMP-9,
caspase-8,
caspase-3,
p53,
p38,
Erk,
JNK,
beclin-1
LC3B
were
also
discussed.
Moreover,
clinical
relevance
flavonoid
targets
discussed
comparison
small
inhibitors:
ralimetinib,
AMG232,
marimastat,
hydroxychloroquine
chloroquine.
positive
pre-clinical
results,
further
investigations
studies
warranted
substantiate
efficacy
safety
use
on
patients.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 559 - 559
Published: Feb. 17, 2024
The
most
common
malignant
gynecologic
diseases
are
cervical,
uterine,
ovarian,
vaginal,
and
vulvar
cancer.
Among
them,
ovarian
cancer
causes
more
deaths
than
any
other
of
the
female
reproductive
system.
A
great
number
women
suffer
from
endometriosis,
uterine
fibroids
(UFs),
adenomyosis,
dysmenorrhea,
polycystic
ovary
syndrome
(PCOS),
which
widespread
benign
health
problems
causing
troublesome
painful
symptoms
significantly
impairing
quality
life
affected
women,
they
some
main
infertility.
In
addition
to
available
surgical
pharmacological
options,
effects
supporting
standard
treatment
with
naturally
occurring
compounds,
mainly
polyphenols,
being
studied.
Catechins
responsible
for
majority
potential
benefits
attributed
green
tea
consumption.
Epigallocatechin
gallate
(EGCG)
is
considered
a
non-toxic,
natural
compound
anticancer
properties.
Antioxidant
action
its
function,
but
attention
also
drawn
participation
in
cell
division
inhibition,
apoptosis
stimulation
epigenetic
regulation.
this
narrative
review,
we
describe
role
EGCG
consumption
preventing
development
disorders
such
as
UF,
PCOS,
well
conditions.
We
discuss
possible
mechanisms
that
may
be
related
EGCG.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 212 - 212
Published: Jan. 8, 2025
Tea
is
a
significant
source
of
flavonoids
in
the
diet.
Due
to
different
production
processes,
amount
bioactive
compounds
unfermented
(green)
and
(semi-)fermented
tea
differs.
Importantly,
green
has
similar
composition
phenolic
fresh,
unprocessed
leaves.
It
consists
primarily
monomeric
flavan-3-ols,
known
as
catechins,
which
epigallocatechin
gallate
(EGCG)
most
abundant.
Thanks
its
antioxidant,
antiproliferative,
antiangiogenic
properties,
EGCG
attracted
scientific
community's
attention
potential
use
preventing
and/or
combating
cancer.
In
this
review
article,
we
summarize
literature
reports
found
Google
Scholar
PubMed
databases
on
anticancer
effect
selected
malignant
neoplasms
women,
i.e.,
breast,
cervical,
endometrial,
ovarian
cancers,
have
been
published
over
last
two
decades.
needs
be
emphasized
that
concentrations
reported
effective
against
cancer
cells
are
typically
higher
than
those
plasma
after
polyphenol
administration.
Moreover,
low
bioavailability
absorption
appear
main
reasons
for
differences
effects
between
vitro
vivo
studies.
context,
also
decided
look
at
possible
solutions
these
problems,
consisting
combining
with
other
components
or
using
nanotechnology.
Despite
promising
results
studies
conducted
so
far,
mainly
animal
models,
there
no
doubt
further,
broad-based
activities
necessary
unequivocally
assess
oncological
treatment
combat
women.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(4), P. 2181 - 2196
Published: Jan. 1, 2024
(-)-Epigallocatechin-3-gallate
(EGCG)
is
a
major
polyphenol
in
tea
and
exerts
several
health-promoting
effects.
It
easily
autoxidizes
into
complex
polymers
becomes
deactivated
due
to
the
presence
of
multiple
phenolic
hydroxyl
structures.
Nonetheless,
morphology
biological
activity
EGCG
are
yet
be
clarified.
The
present
study
demonstrated
that
autoxidation
self-assembled
nanoparticles
(ENPs)
exhibit
antioxidant
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
The Plant Genome,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 14, 2025
Abstract
The
plant
Polygonum
capitatum
(
P.
)
contains
a
variety
of
flavonoids
that
are
distributed
differently
among
different
parts.
Nevertheless,
differentially
expressed
genes
(DEGs)
associated
with
this
heterogeneous
distribution
have
not
been
identified.
In
study,
combined
transcriptomic
and
metabonomic
analysis,
we
identified
significant
DEGs
related
to
variations
in
flavonoid
composition
parts
.
Subsequently,
nontargeted
metabolomic
analyses
revealed
phenolic
acids
were
significantly
enriched
the
phenylpropanoid
biosynthesis,
shikimic
acid
biosynthesis
pathways.
expression
levels
encoding
enzymes,
including
shikimate
O
‐hydroxycinnamoyltransferase
(HCT),
chalcone
synthase
(CHS),
3′,5′‐hydroxylase
(CYP75A),
flavones
3‐hydroxylase
(F3H),
flavonol
(FLS),
leucoanthocyanidin
reductase
(LAR),
trans‐cinnamate
4‐monooxygenase
(CYP73A),
kinase
(SK),
found
be
lowest
leaves
via
quantitative
PCR.
Interestingly,
these
involved
quality
markers
such
as
gallic
acid,
quercetin,
quercitrin
Finally,
targeted
results
reconfirmed
contents
highest
This
research
provides
theoretical
basis
for
further
understanding
differential
regulatory
mechanism
metabolism
,
providing
novel
insights
into
pharmacognostic
