Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 19, 2024
Honokiol,
a
naturally
occurring
compound
from
Magnolia
obovata
Thunb
.,
has
many
biological
activities,
but
its
anti-α-glucosidase
activity
is
still
unclear.
Therefore,
we
determined
inhibitory
effects
against
α-glucosidase.
Activity
assays
showed
that
honokiol
was
reversible
mixed-type
inhibitor
of
α-glucosidase,
and
IC
50
value
317.11
±
12.86
μM.
Fluorescence
results
indicated
the
binding
to
α-glucosidase
caused
reduction
in
activity.
3D
fluorescence
CD
spectra
conformational
change
Docking
simulated
detailed
interactions
between
including
hydrogen
hydrophobic
bonds.
All
findings
could
be
used
as
natural
develop
agents.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Diabetic
wound
healing
(DWH)
represents
a
major
complication
of
diabetes
where
inflammation
is
key
impediment
to
proper
healing.
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
signaling
pathway
has
emerged
as
central
mediator
inflammatory
responses
cell
stress
and
damage.
However,
the
contribution
cGAS-STING
activation
impaired
in
DWH
remains
understudied.
In
this
review,
we
examine
evidence
that
cGAS-STING-driven
critical
factor
underlying
defective
DWH.
We
summarize
studies
revealing
upregulation
diabetic
wounds
discuss
how
exacerbates
senescence
disrupts
cellular
metabolism
block
Partial
pharmaceutical
inhibition
shown
promise
damping
improving
preclinical
models.
highlight
knowledge
gaps
regarding
DWH,
including
its
relationships
with
endoplasmic
reticulum
metal-ion
signaling.
Elucidating
these
mechanisms
may
unveil
new
therapeutic
targets
within
improve
outcomes
This
review
synthesizes
current
understanding
contributes
pathology
proposes
future
research
directions
exploit
modulation
for
benefit.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: June 1, 2024
Nuclear
lamin
B1
(LMNB1)
is
a
member
of
the
nuclear
protein
family.
LMNB1
can
maintain
and
ensure
stability
structure
influence
process
cell
senescence
by
regulating
chromatin
distribution,
DNA
replication
transcription,
gene
expression,
cycle,
etc.
In
recent
years,
several
studies
have
shown
that
abnormal
expression
LMNB1,
classical
biomarker
senescence,
highly
correlated
with
progression
various
malignant
tumors;
therefore
considered
new
potential
tumor
marker
therapeutic
target.
However,
mechanism
action
influenced
many
factors,
which
are
difficult
to
clarify
at
present.
This
article
focuses
on
progress
in
understanding
role
tumors
offers
insights
could
contribute
elucidating
provide
direction
for
further
research.
