Sevoflurane Preconditioning Downregulates GRIA1 Expression to Attenuate Cerebral Ischemia–Reperfusion-Induced Neuronal Injury DOI
Ye Li, Zhi Liang,

Shuyan Lei

et al.

Neurotoxicity Research, Journal Year: 2023, Volume and Issue: 41(1), P. 29 - 40

Published: Jan. 3, 2023

Language: Английский

Identification and characterization of extrachromosomal circular DNA in large‐artery atherosclerotic stroke DOI Creative Commons
Kejie Chen,

Yanqi Chi,

Hang Cheng

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(7)

Published: March 20, 2024

Abstract Extrachromosomal circular DNA (eccDNA) is a new biomarker and regulator of diseases. However, the role eccDNAs in large‐artery atherosclerotic (LAA) stroke remains unclear. Through high‐throughput circle‐sequencing technique, length distribution, genomic characteristic motifs feature plasma eccDNA from healthy controls (CON) patients with LAA were analysed. Then, potential functions annotated investigated using GO KEGG pathway analyses. EccDNAs mapped to reference genome showed SHN3 BCL6 unique transcription factors. The genes differentially expressed between CON mainly involved axon/dendrite/neuron projection development maintenance cellular structure via Wnt, Rap1 MAPK pathways. Moreover, played regulation coagulation fibrinolysis, there five (Chr2:12724406‐12724784, Chr4:1867120‐186272046, Chr4:186271494‐186271696, Chr7:116560296‐116560685 Chr11:57611780‐5761192). Additionally, POLR2C AURKA carried by ecDNAs (eccDNA size >100 kb) significantly associated stroke. Our data firstly revealed characteristics genes, suggesting novel mechanism

Language: Английский

Citations

2
Argon neuroprotection in ischemic stroke and its underlying mechanism DOI Creative Commons
Li Bao,

Yongxin Liu,

Qi Jia

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 212, P. 110964 - 110964

Published: April 25, 2024

Ischemic stroke (IS), primarily caused by cerebrovascular obstruction, results in severe neurological deficits and has emerged as a leading cause of death disability worldwide. Recently, there been increasing exploration the neuroprotective properties inert gas argon. Argon exhibited impressive neuroprotection many vivo ex experiments without signs adverse effects, coupled with advantages being inexpensive easily available. However, efficient administration strategy underlying mechanisms argon IS are still unclear. This review summarizes current research on effects goal to provide effective guidance for application elucidate potential neuroprotection. Early appropriate at high concentration possible offers favorable IS. inhalation shown some long-term protection benefits. provides anti-oxidative stress, anti-inflammatory anti-apoptotic cytoprotective mainly around Toll-like receptor 2/4 (TLR2/4), mediated extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), kappa-B (NF-ĸB) B-cell leukemia/lymphoma (Bcl-2). Therefore, holds significant promise novel clinical agent ischemic after further researches identify optimal mechanism.

Language: Английский

Citations

2
Mechanistic exploration of ubiquitination-mediated pathways in cerebral ischemic injury DOI

Supriya Khanra,

Shareen Singh,

Thakur Gurjeet Singh

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Nov. 28, 2024

Language: Английский

Citations

2
The therapeutic effects of salvianolic acids on ischemic stroke: From molecular mechanisms to clinical applications DOI Creative Commons
Chao Zhao, Xiaodan Bai, Aidong Wen

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107527 - 107527

Published: Nov. 1, 2024

Language: Английский

Citations

2
Sevoflurane Preconditioning Downregulates GRIA1 Expression to Attenuate Cerebral Ischemia–Reperfusion-Induced Neuronal Injury DOI
Ye Li, Zhi Liang,

Shuyan Lei

et al.

Neurotoxicity Research, Journal Year: 2023, Volume and Issue: 41(1), P. 29 - 40

Published: Jan. 3, 2023

Language: Английский

Citations

6