Effect of meta-topolin on in vitro shoot multiplication, rooting, and genetic integrity of Rubia cordifolia L

In Vitro Cellular & Developmental Biology - Plant, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

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Microwave-Assisted Extraction of Natural Dye from Rubia tinctorum L. Plant for Dyeing Wool Fabrics with Multiple Effects

Fibers and Polymers, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

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Isolation of anthraquinone derivatives from Rubia cordifolia (Rubiaceae) and their bioactivities against plant pathogenic microorganisms

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(9), P. 4617 - 4627

Published: May 15, 2024

Abstract BACKGROUND The discovery of antimicrobial ingredients from natural products could be an effective way to create novel fungicides. Rubia cordifolia L., a traditional Chinese herb, may have effects on plant pathogens according our previous screening study. RESULTS L. extracts had moderate inhibitory apple Valsa canker ( mali ) and tomato grey mould Botrytis cinerea at concentration 10 mg mL −1 . With the use bioguided isolation methods, eight compounds 1–8 were obtained, including new compound 2,2,6‐trimethyl‐6‐(4‐methylphenyl)‐tetrahydropyrano‐ 3‐ol 7 ), seven quinone derivatives. Two compounds, mollugin 1 1,3,6‐trihydroxy‐2‐methylanthraquinone 6 found exhibit outstanding antifungal activities against V. Phytophthora capsici Leon. half maximal (EC 50 79.08 81.78 μg , respectively, EC P. was 4.86 Compound also showed excellent activity tobacco mosaic virus (TMV). inactive, inductive, protective curative TMV 84.29%, 83.38%, 86.81%, 60.02%, 500 which all close or greater than that positive control (100 chitosan oligosaccharide, COS). CONCLUSION Mollugin are potentially valuable active lay foundation for research botanical fungicide derived R. provide lead structures derivative synthesis structural modification. © 2024 Society Chemical Industry.

Language: Английский

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Effects of geographical, soil and climatic factors on the two marker secondary metabolites contents in the roots of Rubia cordifolia L.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: June 11, 2024

The growth and quality of medicinal plants depend heavily on environmental variables. Rubia cordifolia , an important plant, is determined by the two main secondary metabolites root, purpurin mollugin. However, their relationship with factors has not been studied. In this study, mollugin contents R. roots from different sampling sites in China were measured using ultra-high-performance liquid chromatography, correlations between variables analyzed. results showed that there significant differences at points. content ranged 0.00 to 3.03 mg g -1 while 0.03 10.09 . Shanxi, Shaanxi Henan border areas southeastern Liaoning was higher. expected become a planting area Northeast China. Correlation regression analysis revealed affected factors, positively correlated longitude latitude, negatively soil nutrients. addition, higher temperature shorter sunshine duration facilitated synthesis purpurin. Annual precipitation might be factor limiting because it had opposite effects major metabolites. Therefore, study great significance for selection improvement field quality.

Language: Английский

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An efficient direct organogenesis protocol for in vitro clonal propagation of Rubia cordifolia L.

Industrial Crops and Products, Journal Year: 2023, Volume and Issue: 208, P. 117856 - 117856

Published: Nov. 28, 2023

Language: Английский

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Oxomollugin, an oxidized substance in mollugin, inhibited LPS-induced NF-κB activation via the suppressive effects on essential activation factors of TLR4 signaling

Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 78(3), P. 568 - 575

Published: April 2, 2024

Language: Английский

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The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122862 - 122862

Published: June 24, 2024

Language: Английский

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Progression in Nano-Botanical Oral Hygiene Solutions: The Dawn of Biomimetic Nanomaterials

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100219 - 100219

Published: Sept. 1, 2024

Language: Английский

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Rubia cordifolia L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1586 - 1586

Published: Nov. 9, 2023

Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects roots Rubia cordifolia L. (R. L.) in Wistar rat model for diabetic and possible neuroprotective, antidiabetic, analgesic mechanisms underlying this effect.Rats were divided into five experimental groups. An amount 0.25% carboxy methyl cellulose (CMC) saline streptozotocin (STZ) (60 mg/kg) was given to group 1 2, respectively. Group 3 treated with STZ glibenclamide simultaneously while groups 4 5 hydroalcoholic extract root R. cordifolia, Hot plate cold allodynias used evaluate pain threshold. antioxidant assessed by measuring Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD). At end study, sciatic nerve brain tissues collected histopathological study. Bcl-2 proteins, cleaved caspase-3, Bax through Western blot method.R. significantly attenuated paw withdrawal tail flick latency neuropathic rats. (p < 0.01) improved levels oxidative stress. It found decrease blood glucose increase animal weight cordifolia-treated Treatment suppressed caspase-3 Bax:Bcl2 ratio tissue compared group. Histopathological analysis also revealed marked improvement architecture loss axons at higher dose (400 mg/kg).R. its antidiabetic properties ameliorating apoptosis

Language: Английский

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The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics

Drug Design Development and Therapy, Journal Year: 2023, Volume and Issue: Volume 17, P. 439 - 457

Published: Feb. 1, 2023

Purpose: Rubia cordifolia L. (RC) is a classic herbal medicine for the treatment of rheumatoid arthritis (RA) and has been used since ancient times.The ethanol extract (RCE) showed obvious anti-RA effects in our previous study.However, further potential mechanisms require more exploration.We aimed to investigate mechanism RCE RA by integrating metabolomics network pharmacology this study.Methods: An adjuvant-induced (AIA) rat model was established, we evaluated therapeutic RCE.Metabolomics serum urine identify differential metabolites.Network applied determine key metabolites targets.Finally, targets compounds were verified molecular docking. Results:The results indicated that suppressed foot swelling alleviated joint damage also had anti-inflammatory properties inhibiting expressions tumor necrosis factor (TNF)-α, Interleukin (IL)-1β, prostaglandin E2 (PGE2), P65.Ten seven found urine, respectively, rats.Six targets, ie, phospholipase A2 group IIA (PLA2G2A), X (PLA2G10), cytidine deaminase (CDA), uridine-cytidine kinase 2 (UCK2), charcot-leyden crystal galectin (CLC), 5′,3′-nucleotidase, mitochondrial (NT5M), discovered metabolite analysis be related glycerophospholipid metabolism pyrimidine metabolism.Molecular docking confirmed favorable affinities with including alizarin, 6-hydroxyrubiadin, ruberythric acid, munjistin. Conclusion:This study revealed underlying provided evidence will allow researchers functions components against RA.

Language: Английский

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