Gut Microbiota and Vascular Diseases: An Update DOI Creative Commons
Jiaqi Wu, Yuxuan Li,

Peipei Yang

et al.

Cardiovascular Innovations and Applications, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Vascular diseases, including atherosclerosis, aneurysms, and vascular calcification, are a leading cause of morbidity mortality worldwide. In past decades, the gut microbiota has been found to be an indispensable population exerting effects on hosts under physiological pathological conditions. Gut microbiota-derived metabolites, such as trimethylamine-N-oxide short-chain fatty acids, mediate these by regulating cells systematically. Translation research knowledge clinical scenarios led development new therapies dietary interventions metabolite inhibitors. This review describes recent advancements in understanding interplay between dysfunction, potential treatments for diseases.

Language: Английский

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice: Compared Evaluation of Liraglutide and Semaglutide Intervention DOI Creative Commons
Chuanhao Xiong,

Jingzhu Wu,

Yuhang Ma

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 865 - 880

Published: Feb. 1, 2024

Purpose: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility in reproductive-age women. Our work aims to evaluate the effects glucagon-like peptide-1 receptor agonists (GLP-1RAs) on gut microbiota, with metabolic parameters including body weight and hormone profile PCOS. Patients Methods: Dehydroepiandrosterone (DHEA)-induced PCOS mice were established then treated two GLP-1RAs: liraglutide novel form semaglutide for four weeks. Changes measured. Fecal samples collected analyzed using metagenomic sequencing. Results: Liraglutide modulated both alpha beta diversity microbiota increased Bacillota-to-Bacteroidota ratio through up-regulating abundance butyrate-producing members Bacillota like Lachnospiraceae. Moreover, showed ability reverse altered microbial composition disrupted functions caused by Semaglutide Helicobacter (p < 0.01) which was only bacteria found negatively correlated weight. pathways involving porphyrin flavonoids after intervention. Conclusion: improved reproductive disorders modulating whole structure The greater efficacy loss compared observed intervention positively related . study may provide new ideas treatment underlying mechanisms GLP-1RAs improve Keywords: PCOS, GLP-1 agonists, metabolism

Language: Английский

Citations

4
Intestinal mucosal barrier: a potential target for traditional Chinese medicine in the treatment of cardiovascular diseases DOI Creative Commons
Jiahui Liu, Xiunan Wei, Tong Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Graphical Abstract This review presents the progress of traditional Chinese medicines in treating CVD by repairing intestinal mucosal barrier

Language: Английский

Citations

4
Differences in the intestinal microbiota and association of host metabolism with hair coat status in cattle DOI Creative Commons
Donglin Wu, Pengfei Zhao, Chunjie Wang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 22, 2024

Introduction The hair coat status of cattle serves as an easily observed indicator economic value in livestock production; however, the underlying mechanism remains largely unknown. Therefore, objective current study was to determine differences intestinal microbiota and metabolome based on a division with either slick shining (SHC) or rough dull (MHC) Simmental cows. Methods Eight SHC eight MHC late-pregnancy cows (with similar parities, body weights, conditions) were selected their status, blood samples (plasma) from coccygeal venipuncture fecal rectum collected. (in samples) characterized by employing 16S rRNA gene sequencing targeting V3–V4 hypervariable region Illumina MiSeq PE300 platform, plasma subjected LC–MS/MS-based metabolomics Progenesis QI 2.3. Plasma macromolecular metabolites examined for metabolism lipids, proteins, mineral elements, hormones. Results Notable between groups related host ( P &lt; 0.05). enriched histidine metabolism, cysteine methionine purine group, also In symbiotic relationship transitioned cooperation competition uncoupling effect present microbe–metabolite association intestine microbiota–host interactions. hubs mediating relationships bacterial genus g__norank_f__Eubacterium_coprostanoligenes_group , inosine, triiodothyronine, phosphorus, which could be used differentiate cows’ Conclusion Overall, identified features thereby providing evidence new direction (intestine interplay) future studies aimed at understanding cattle.

Language: Английский

Citations

4
Natural Saponins on Cholesterol‐Related Diseases: Treatment and Mechanism DOI Open Access

Man‐Yu Xiao,

Si Li, Wenjing Pei

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

ABSTRACT Saponins are compounds composed of lipophilic aglycones linked to hydrophilic sugars. Natural saponins isolated from plants and some Marine organisms. As important cholesterol‐lowering drugs, natural have attracted wide attention for their therapeutic potential in a variety cholesterol‐related metabolic diseases. To review the effects on diseases, deepen understanding mechanism saponins. The literature related diseases was collected using keywords “saponins” “cholesterol” PubMed, Web Science, Google Scholar January 2000 May 2024. total number articles 240 after excluding irrelevant articles. can regulate cholesterol prevent treat such as atherosclerosis, diabetes, liver disease, hyperlipidemia, cancer, obesity. Mechanistically, synthesis uptake through AMPK/SREBP2/3‐hydroxy‐3‐methyl‐glutaryl coenzyme A reductase pathway PCSK9/LDLR pathway, efflux esterification targeting Liver X receptor/ABC ACAT family. broad application prospects regulating metabolism, development more drugs provides new train thought. However, it is still necessary further explore molecular expand clinical trials provide evidence.

Language: Английский

Citations

0
Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS DOI Creative Commons
Yufan Zhang, Xi Chen, Oushan Tang

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 13, 2025

Atherosclerosis is a primary cause of cardiovascular disease, straining healthcare systems. Dendrobium officinale, widely used food-medicine homology, has demonstrated anti-atherosclerotic (anti-AS) properties, with other species listed in pharmacopoeias exhibiting similar effects. However, their efficacy varies, and the impact interspecies variations on compounds mechanisms Dendrobium's anti-AS effects remains unclear. This study aimed to explore across various species. The chemical composition D. fimbriatum, devonianum, gratiosissimum, catenatum was analyzed using UPLC-Q-Exactive Orbitrap MS. Network pharmacology predicted pharmacological basis molecular mechanisms. Molecular docking experiments assessed binding affinity identified target proteins. A total 12 different 65 common components were identified. Key therapeutic targets included SRC, STAT3, PIK3CA, along relevant signaling pathways linked AS prevention. provides insights into differences properties.

Language: Английский

Citations

0
Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota DOI Creative Commons
Xiao Han,

Bingxin Huangfu,

Tongxiao Xu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117664 - 117664

Published: Jan. 1, 2025

Language: Английский

Citations

0
Aerobic exercise regulates gut microbiota profiles and metabolite in the early stage of Alzheimer's disease DOI Creative Commons

Cuilan Wei,

Xiaojing Wu,

Chuikun Li

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 20, 2025

Abstract Aerobic exercise (AE) has been shown to offer significant benefits for Alzheimer's disease (AD), potentially influencing the gut microbiota. However, impact of changes in intestinal flora early induced by aerobic on metabolic pathways and metabolites is not well understood. In this study, 3‐month‐old APP/PS1 C57BL/6 mice were divided into two groups each: a control group (ADC WTC C57BL/6) an (ADE WTE C57BL/6). The underwent 20‐week training program motorized treadmill before behavioral test (both Morris water maze experiment (MWM) eight‐arm test). Fecal samples collected analyze microbiota profiles via 16S rRNA gene sequencing. At same time, pathway analysis detection carried out. phylum level, ADE exhibited reduced relative abundance Bacteroidetes compared ADC group. genus both Ileibacterium Faecalibaculum found be more abundant than Additionally, PICRUSt revealed that lipid metabolism bile acid significantly enriched cecal detected further confirmed mentioned above. may modify mice, thereby playing beneficial role delaying cognitive impairment associated with early‐stage disease.

Language: Английский

Citations

0
Endophytic fungi as sources of cardiovascular drug leads DOI

Ruth Assumi,

Shilpy Singh,

Bhawana

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 201 - 232

Published: Jan. 1, 2025

Language: Английский

Citations

0
Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites DOI Creative Commons

Liang Feng,

J. Feng,

Li He

et al.

Applied Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 29 - 29

Published: March 13, 2025

Atherosclerosis (AS) is emerging as a major global public health problem. Researchers are developing and implementing various anti-AS strategies. This study aimed to investigate gut microbiota metabolite changes associated with elevated serum low-density lipoprotein cholesterol (LDL-c). Mice were divided into two equal groups: Group C (mice from healthy subjects) B AS). At the end of 8-week study, blood samples collected for lipid analysis; rectal feces microbial 16S rRNA sequencing analysis metabolomics analysis. Our results showed that group significantly increased levels LDL-c. However, no statistically significant differences observed in richness diversity microbiota, but we an increase ratio Firmicutes Bacteroidetes abundance Parabacteroides Goldstein. In addition, untargeted metabolomic fecal revealed 128 metabolites differentially expressed between groups B. Notably, was found have involved metabolism pathways, such estrogen glucuronide, ginsenoside f1, Pe (16:1e/14,15-epete), prostaglandin E1. Those data highlight importance understanding AS perspective establish foundation future research on AS.

Language: Английский

Citations

0
Ginsenosides and gut microbiota: differential effects on healthy individuals and irritable bowel syndrome subtypes DOI Creative Commons
Du Zhi, Cheng Zhao,

Jiabin Li

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19223 - e19223

Published: April 15, 2025

Background Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with poorly understood mechanisms. Variations in gut microbiota composition are observed different IBS subtypes. Ginsenosides have shown potential alleviating symptoms, but their interactions subtypes not well studied. Methods In this study, we investigated the effects of ginsenosides on both healthy participants and suffering from characterized by diarrhea (IBS-D) or constipation (IBS-C), using vitro fermentation alongside 16S rRNA sequencing bioinformatics analyses. Results The analysis demonstrated that there were no statistically significant alterations α- β-diversity between ginsenosides-treated control groups across all models. However, microbial assessment revealed presence 51 shared genera, notable variations enrichment specific taxa. Specifically, LEfSe that, following treatment, model exhibited Stenotrophomonas Achromobacter , while IBS-D Pseudomonas . Conclusions results elucidate distinctive signatures associated treatment groups, underscoring therapeutic efficacy modulating microbiota. This study highlights necessity for further investigation into targeted microbiome therapies IBS, which may facilitate development more personalized efficacious strategies health.

Language: Английский

Citations

0