Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis DOI Creative Commons
Enfu Tao,

Dandan Lang

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

Kawasaki disease (KD), an acute systemic vasculitis that primarily affects children under 5 years of age, is the leading cause acquired heart in this age group. Recent studies propose a novel perspective on KD's etiology, emphasizing gastrointestinal (GI) tract, particularly role gut permeability. This review delves into how disruptions barrier function trigger inflammatory responses, exacerbate vascular inflammation, and contribute to coronary artery aneurysms. Evidence suggests with KD often exhibit increased permeability, imbalance immunity subsequent damage. These changes impact endothelial cells, promoting platelet aggregation activation, thereby advancing severe complications, including Additionally, highlights correlation between GI symptoms resistance standard treatments like intravenous immunoglobulin (IVIG), indicating involvement may predict therapeutic outcomes. Advocating for new paradigm, calls integrated research across gastroenterology, immunology, cardiology examine through lens health. The goal develop innovative interventions targeting intestinal barrier, potentially revolutionizing management significantly improving patient

Language: Английский

Triterpenoids from Ilicis Rotundae Cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis DOI
Wei‐Cai Zeng, Mengjia Sun, Jiamin Cao

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156537 - 156537

Published: Feb. 20, 2025

Language: Английский

Citations

0
Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries DOI Creative Commons
Hongyan Zhou, Xinyu Song, Yingying Tian

et al.

Smart Medicine, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 4, 2025

ABSTRACT Hyperuricemia (HUA) is a chronic metabolic disease mainly stemming from purine metabolism disorders and strongly correlated with cardiovascular diseases, gout, kidney disease, other diseases. Elevated levels of uric acid (UA) in serum will lead to vascular endothelial cell injuries directly, subsequently impairing normal functions human blood vessels. Therefore, investigating resulting HUA corresponding drug screening for its treatment are great significance the prevention Given inherent advantages multiple targets pathways, we delved into potential traditional Chinese medicine alleviating induced by detail. Through establishment an injury index library subsequent process, isoliquiritigenin proved be promising candidate promoting repair HUA‐induced injuries. It had been identified, validated efficiency evaluated using vessel‐on‐a‐chip animal tests. Additionally, network pharmacology molecular docking were further employed elucidate underlying mechanism. This work represents first demonstration isoliquiritigenin's capacity facilitate triggered high UA levels, provides valuable insights medicine.

Language: Английский

Citations

0
Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity DOI Creative Commons
Laura Franza, Mario Caldarelli, Emanuele Rocco Villani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1645 - 1645

Published: July 24, 2024

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.

Language: Английский

Citations

1
Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis DOI Creative Commons
Enfu Tao,

Dandan Lang

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

Kawasaki disease (KD), an acute systemic vasculitis that primarily affects children under 5 years of age, is the leading cause acquired heart in this age group. Recent studies propose a novel perspective on KD's etiology, emphasizing gastrointestinal (GI) tract, particularly role gut permeability. This review delves into how disruptions barrier function trigger inflammatory responses, exacerbate vascular inflammation, and contribute to coronary artery aneurysms. Evidence suggests with KD often exhibit increased permeability, imbalance immunity subsequent damage. These changes impact endothelial cells, promoting platelet aggregation activation, thereby advancing severe complications, including Additionally, highlights correlation between GI symptoms resistance standard treatments like intravenous immunoglobulin (IVIG), indicating involvement may predict therapeutic outcomes. Advocating for new paradigm, calls integrated research across gastroenterology, immunology, cardiology examine through lens health. The goal develop innovative interventions targeting intestinal barrier, potentially revolutionizing management significantly improving patient

Language: Английский

Citations

0