Macrophage polarization: an important role in inflammatory diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Macrophages are crucial cells in the human body's innate immunity and engaged a variety of non-inflammatory reactions. can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages anti-inflammatory M2-type macrophages. During inflammation, activated alternatively, maintaining reasonably steady ratio is critical for homeostasis

Language: Английский

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The role of AMPK in macrophage metabolism, function and polarisation

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 8, 2023

AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays key role regulating cellular homeostasis multiple aspects cell metabolism. During macrophage polarisation, AMPK not only guides the metabolic programming macrophages, but also counter-regulates inflammatory function macrophages promotes their polarisation toward anti-inflammatory phenotype. located at intersection metabolism inflammation. The characteristics are closely related to immune-related diseases, infectious cancer progression immunotherapy. This review discusses structure its metabolism, macrophages. In addition, it summarises important pathway activators development macrophage-related diseases.

Language: Английский

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Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 6, 2022

Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over past two decades, polytrophic, pharmacological, and biochemical properties BBR have been intensively studied. The key functions BBR, including anti-inflammation, antibacterial, antioxidant, anti-obesity, even antitumor, discovered. However, underlying mechanisms BBR-mediated regulation still need to be explored. Given that is also natural nutrition supplement, modulatory effects on nutritional immune responses attracted more attention investigators. In this mini-review, we summarized latest achievements inflammation, gut microbes, macrophage polarization, associated with their possible tools pathogenesis therapy ulcerative colitis cancer recent 5 years. We discuss therapeutic efficacy anti-inflammatory actions benefit future clinical applications.

Language: Английский

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A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 1, 2023

Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and incurable symptoms, causes immense suffering economic burden for patients due to the limited treatment options available. Therefore, it is imperative develop novel promising strategies, as well safe effective drugs, clinical management UC. Macrophages play critical role initial line defense in maintaining intestinal immune homeostasis, their phenotypic transformation significantly influences progression Scientific studies have demonstrated that directing macrophage polarization toward M2 phenotype an strategy prevention Phytochemicals derived from botanical sources garnered interest scientific community owing distinct bioactivity nutritional value, which been shown confer beneficial protective effects against colonic inflammation. In this review, we explicated influence on development UC collated data significant potential natural substances can target elucidate possible mechanism action its treatment. These findings may provide directions references

Language: Английский

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Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 110996 - 110996

Published: Sept. 29, 2023

Language: Английский

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Akkermansia muciniphila relieves inflammatory response in DSS-induced ulcerative colitis in mice through regulating macrophage polarization via SCFAs-SLC52A2/FFAR2 pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114545 - 114545

Published: Feb. 1, 2025

Language: Английский

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Artesunate alleviated murine ulcerative colitis by regulating immune response through inhibiting endoplasmic reticulum stress

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Innate and adaptive immunity are intricately linked to the pathogenesis of ulcerative colitis (UC), with dysregulation Treg/Th17 balance M2/M1 macrophage polarization identified as critical factors. Artesunate (ARS) has previously been shown alleviate UC by inhibiting endoplasmic reticulum stress (ERS). To further investigate regulatory effects ARS on immune associated role ERS in this process, an experimental model was established using dextran sulfate sodium (DSS). Flow cytometry employed assess changes Th17/Treg cell ratio spleen intestine, while RT-qPCR used quantify transcription levels relevant genes colonic tissues. treatment significantly mitigated DSS-induced pathological damage, reduced proportion CD4+Th17 cells, downregulated mRNA expression IL-17A, IL-17F, RORγt, concurrently increasing CD4+Treg cells upregulating TGF-β expression. Additionally, restored decline enhanced Arg-1 IL-10, suppressing pro-inflammatory markers, including iNOS, IL-1β, IL-6, TNF-α. Notably, co-treatment 4-phenylbutyric acid (4-PBA, inhibitor) augmented immunoregulatory ARS, whereas 2-deoxy-D-glucose (2-DG, agonist) counteracted its protective activity against UC. These findings suggest that plays a crucial mediating therapeutic UC, particularly modulating polarization. This study provides insights into mechanistic basis offering potential avenue for intervention.

Language: Английский

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Dexamethasone-Loaded Lipid Calcium Phosphate Nanoparticles Treat Experimental Colitis by Regulating Macrophage Polarization in Inflammatory Sites

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 993 - 1016

Published: Jan. 1, 2024

Background: The M1/M2 polarization of intestinal macrophages exerts an essential function in the pathogenesis ulcerative colitis (UC), which can be adjusted to alleviate UC symptoms. Purpose: A kind pH-sensitive lipid calcium phosphate core-shell nanoparticles (NPs), co-loading with dexamethasone (Dex) and its water-soluble salts, sodium (Dsp), was constructed comprehensively regulate different states towards M2 phenotype promote anti-inflammatory effects. Methods: Dex Dsp were loaded outer shell inner (Cap) core L d CaP NPs, respectively. Then, morphology NPs methods for determining drug concentration investigated, followed by vitro protein adsorption, stability, release tests. Cell experiments evaluated cytotoxicity, cellular uptake, macrophage induction ability NPs. vivo distribution effect through a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced BALB/c mice model. Results: showed particle size about 200 nm achieved considerable loading amounts Dsp. studies revealed that acidic microenvironment, cationic underwent protonated dissociation first creating microenvironment conducive polarization. exposed further engulfed M1 restrict pro-inflammatory cytokines production inhibiting activation nuclear factor kappa-B (NF-κB) activating GC receptor NF kappa B inhibitor α (I-κBα), respectively, ultimately reversing therapy. Conclusion: accomplished sequential site inflammatory at this site, promoting regulation accelerate remission Keywords: colitis, phosphate, polarization, colon targeted delivery system,

Language: Английский

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Modified Zhenwu Decoction suppresses chronic colitis via targeting macrophage CCR2/Fyn/p38 MAPK signaling axis

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155694 - 155694

Published: May 1, 2024

Ulcerative colitis (UC) is associated with intestinal macrophage infiltration due to disruption of the mucosal barrier and bacterial invasion. Therefore, it crucial identify therapeutic agents capable attenuating macrophage-induced inflammatory response preserve homeostasis immune tolerance. The modified Zhenwu decoction (CDD-2103) a novel herbal formulation developed based on principles Traditional Chinese medicine. To date, there are no clinically approved formulations for UC well-known mechanism action macrophages. objective this study was systematically investigate inhibitory effect active fraction CDD-2103 in mouse model chronic delineate mechanisms underlying its action. extracted into four fractions using organic solvents increasing polarity. A 49-day dextran sulfate sodium (DSS)-induced mice model, closely resembling human clinical conditions, used examine colitis. confirm macrophages adoptive transfer CCL2 supplementation were conducted. further elucidated utilizing bone marrow-derived (BMDMs). Transcriptome analysis conducted gain insights BMDMs. Our vitro vivo findings demonstrated that ethanol-enriched exhibited significant anti-inflammatory effects, leading suppression severity. This diminished accumulation colonic lamina propria CDD-2103-intervened mice. Specifically, inhibited CCR2/L2-mediated proinflammatory colon without affecting proliferation. Mechanistically, Fyn expression-mediated p38 MAPK activation subsequently suppressed CCR2 expression Collectively, our supports potential use limit infiltration, thereby reducing inflammation during treatment. components ethanolic promising candidates development drugs management. Additionally, underscores Fyn-mediated as target management UC.

Language: Английский

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