Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 17, 2024
The
increasing
life
expectancy
observed
in
recent
years
has
resulted
a
higher
prevalence
of
late-onset
hypogonadism
(LOH)
older
men.
LOH
is
characterized
by
the
decline
testosterone
levels
and
can
have
significant
impacts
on
physical
mental
health.
While
underlying
causes
are
not
fully
understood,
there
growing
interest
exploring
role
inflammaging
its
development.
Inflammaging
concept
that
describes
chronic,
low-grade,
systemic
inflammation
occurs
as
result
aging.
This
inflammatory
state
been
implicated
development
various
age-related
diseases.
Several
cellular
molecular
mechanisms
identified
contributors
to
inflammaging,
including
immune
senescence,
autophagy
defects,
mitochondrial
dysfunction.
Despite
extensive
research
relationship
with
yet
thoroughly
reviewed
literature.
To
address
this
gap,
we
aim
review
latest
findings
related
impact
LOH.
Additionally,
will
explore
interventions
target
potential
treatments
for
International Journal of Innovative Science and Research Technology (IJISRT),
Journal Year:
2024,
Volume and Issue:
unknown, P. 1037 - 1043
Published: May 29, 2024
Withania
somnifera
also
known
as
Ashwagandha
used
rasayana
(tonic)
in
Ayurvedic
system
of
medicine.
It
is
widely
considered
Indian
Ginseng
and
possesses
medicinal
properties
like
adaptogenic,
antistress,
anxiolytic,
anti-arthritic,
anti-inflammatory
etc.
There
long
history
microbes
having
stable
symbiotic
relationship
with
plants
aiding
them
growth
survival.
This
endophytic
been
observed
plants.
study
an
attempt
to
observe
the
biodiversity
fungal
community
understand
their
colonization.
The
was
aimed
isolate
endophytes
from
different
organs
seasonal
variations.
A
total
131
fungi
were
isolated
450
explants
leaves,
stems
roots
W.
somnifera.
overall
colonization
rate
winter,
summer
monsoon
42.67%,
7.33%
37.33%
respectively.
Among
identified
isolates,
most
abundant
frequently
genera
Alternaria,
Fusarium
Chaetomium
sps.
dominant
species
winter
moniliformae
globosum
leaves
17.24%
13.79%
frequency,
While
Alternaria
raphani
40%
density.
In
monsoon,
Microsporum
ferruginem
stem
61.29%
42.86%,
recurring
Ascomycetes
group
alternata
seen
all
seasons.
One
of
the
significant
health
issues
that
plague
people
all
over
world
is
immunological
dysfunction,
which
includes
allergies.
Allergens
include
things
like
pollen,
dust
mites,
food,
cosmetics,
animal
fur,
mold
spores,
and
airborne
particles
from
environment.
Mast
cells
basophils
release
vasoactive
amines,
are
pharmacologically
active
mediators,
as
a
result
crosslinking
bound
IgE
caused
by
second
exposure
to
allergen.
Vasodilation,
increased
vascular
permeability,
smooth
muscle
contraction
brought
on
these
mediators.
Hexosaminidase
an
enzyme
typically
secreted
together
with
histamine
when
granules
in
mast
or
degranulate.
The
rat
basophilic
leukemia
(RBL-2H3)
cell
line
uses
this
biomarker
for
antigen-induced
degranulation.
In
recent
decades,
there
has
been
increase
prevalence
severity
allergic
disorders
such
conjunctivitis,
rhinitis,
asthma,
anaphylaxis,
atopic
eczema,
drug,
insect
allergy,
well
urticarial
angioedema.
Many
ailments
have
treated
plants
traditional
natural
medicine.
Numerous
oriental
medicinal
particular
discovered
exhibit
antiallergic
action
both
vitro
vivo.
Although
their
effectiveness
safety
not
scientifically
established,
used
traditionally
treat
allergy
symptoms.
Plant
polyphenols
potent
properties
crucial
source
development
medications.
chapter,
we
compile
studies
effects
many
secondary
metabolites
immune
system.
PharmaNutrition,
Journal Year:
2024,
Volume and Issue:
29, P. 100399 - 100399
Published: July 2, 2024
Mental
health
issues
affect
millions
of
people
globally,
imposing
significant
emotional
and
economic
burdens.
These
involve
multiple
pathogenic
mechanisms,
including
oxidative
stress
neuroinflammation.
With
an
annual
global
death
estimated
at
9
million,
neurological
disorders
are
the
second
leading
cause
death.
This
review
aims
to
explore
benefits
15
medicinal
plants
available
within
MEA
provide
researchers
with
knowledge
on
how
these
herbal
medicines
could
alleviate
symptoms
associated
changes
in
mental
health.
Academic
databases
were
searched
find
relevant
studies
traditional
herbs
used
for
treatment
related
like
sleep,
anxiety
depression.
The
region
has
highest
prevalence
major
depressive
conventional
treatments
often
involving
medications
that
alter
neurotransmitters,
potentially
adverse
effects.
Given
concerns
about
long-term
drug
use,
there
is
growing
interest
multi-targeted
approaches
using
plants.
offer
a
cost-effective,
less
hazardous
alternative,
especially
those
chronic,
comorbid
conditions.
Medicinal
plant-based
food
supplements
increasing
region,
where
cultural
usage
such
extensive.
However,
practical
application
limited
real-world
scenarios.
While
show
potential
as
cost-effective
more
suitable
alternative
individuals
chronic
conditions
further
research
needed
overcome
limitations
their
focus
real
world
data.
Egyptian Journal of Botany,
Journal Year:
2023,
Volume and Issue:
0(0), P. 0 - 0
Published: Oct. 1, 2023
W
ITHANIA
somnifera
L.
is
widely
used
as
a
medicinal
plant
for
its
therapeutic
properties.In
this
study,
the
impact
of
Chitosan
biotic
stimulus
and
exposure
to
light
UV
rays
physical
stimuli
on
cultured
callus
were
investigated.Compared
control,
results
showed
that
significantly
reduced
fresh
dry
weight
(more
than
70%
decrease),
while
exposing
60
minutes
led
significant
increase
in
weights
(18%
increase).Six
withanolide
compounds
quantified
all
treatments
cultures,
using
HPLC
analysis.The
production
these
was
enhanced
through
elicitation
strategies.Substantially,
at
100
mg/l
stimulated
biosynthesis
27-OH-withanolide-A
(52.0µg/mL,
160%
increase)
compared
150mg/L
displayed
optimal
withanolide-B
(96.3µg/mL,
255%
increase),
27-OH-withanolide-B
(124.6µg/mL,40%
increase).Continued
conditions
(24h/day)
increased
Withaferin-A
Withanone
(179.5µg/mL,82%
increase,
145.3µg/mL,
215%
respectively.While
culture
promoted
formation
withanolide-A
(241.1µg/mL,99%
90
resulted
high
content
(124.8µg/mL,40%
increase).In
conclusion,
elicitors
study
demonstrated
their
efficiency
stimulating
cultures
W.
somnifera.These
findings
provide
valuable
insights
optimizing
Withania
plant,
which
properties.
Egyptian Dental Journal /Egyptian Dental Journal,
Journal Year:
2024,
Volume and Issue:
70(2), P. 1261 - 1274
Published: April 1, 2024
Introduction:
Oral
mucositis
is
a
common
side
effect
of
methotrexate
chemotherapy;
it
represents
challenge
for
successful
cancer
treatment,
as
may
lead
to
discontinuity
the
chemotherapy.
Ashwagandha
one
most
familiar
Ayurveda
herbs
in
India.
Recently,
has
gained
attention
due
its
favorable
biological
effects.
Aim:
Investigation
possible
protective
roots
extract
on
methotrexate-induced
oral
albino
rats.
Materials
and
methods:
40
rats
were
divided
equally
into
4
group:
(C):
received
distilled
water,
(ASH):
300mg/kg
ashwagandha
root
8
days,
(MTX):
single
dose
60
mg/kg
intraperitoneal
injection
day
4,
(MTX/ASH):
daily
days
interrupted
with
i.p
4.Results:
Histopathological
examination
revealed
normal
appearance
tongue
buccal
mucosa
C
ASH
groups.
In
MTX
group
there
was
atrophy
papilla,
decrease
epithelial
thickness,
flattening
rete
pegs,
nuclear
pyknosis,
hyperchromatism,
karyorrhexis,
disruption
basement
membrane,
inflammatory
cells
infiltrate,
blood
vessels
congestion,
muscle
both
mucosae.
MTX/ASH
group,
mucosae
maintained
appearance.
Immunohistochemical
results
significant
Ki67
staining
compared
groups
COX2
increase
groups.Conclusion:
Prophylactic
administration
ameliorated
induced
by
chemotherapy,
therefore
could
be
good
adjuvant
therapy
during
chemotherapeutic
treatment.
Journal of Education Health and Sport,
Journal Year:
2024,
Volume and Issue:
68, P. 50452 - 50452
Published: May 16, 2024
Withania
somnifera,
commonly
known
as
ashwagandha,
has
gained
popularity
in
recent
years
among
individuals
interested
healthy
lifestyles,
natural
medicine,
and
sports.
This
review
aims
to
summarize
the
current
knowledge
regarding
effects
of
ashwagandha
supplementation
on
various
aspects
physical
performance,
particularly
context
resistance
training.
Studies
have
shown
that
can
positively
impact
muscle
strength,
with
significant
increase
force
power
output.
Additionally,
it
demonstrated
potential
modulating
body
composition,
reduction
fat
percentage
noted
certain
populations.
However,
results
studies
ashwagandha’s
effect
size
remain
inconclusive
may
depend
factors
such
training
status
individual
responses.
In
terms
endurance,
been
associated
improvement
maximal
oxygen
uptake,
indicating
enhanced
aerobic
capacity
delayed
exhaustion
during
endurance
activities.
Furthermore,
was
aid
recovery
by
reducing
exercise-induced
damage
inflammatory
response,
potentially
accelerating
regeneration
process.
Ashwagandha
also
influence
hormone
levels,
testosterone
cortisol,
implications
for
growth
recovery.
further
research
is
needed
fully
understand
mechanisms
underlying
these
effects.
Overall,
appears
hold
promise
enhancing
performance
overall
well-being.
Further
elucidate
optimal
dosages,
long-term
safety,
interactions
other
supplements
or
medications.
This
book
chapter
delves
into
the
multifaceted
exploration
of
biotechnologically
enhanced
medicinal
plants
for
allergy
treatment.
The
introductory
section
provides
an
overview
common
medications
and
their
associated
side
effects,
setting
stage
subsequent
discussions.
A
comprehensive
analysis
secondary
metabolites
derived
from
plants,
elucidating
antiallergic
properties
is
presented
highlighting
sources
mechanisms.
categorizes
known
subjected
to
biotechnological
manipulation.
core
explores
diverse
approaches
enhance
plants.
includes
genetic
engineering,
metabolic
pathway
manipulation,
tissue
culture
techniques,
with
specific
attention
given
micropropagation,
somatic
embryogenesis,
cell
suspension
elicitor
intervention,
artificial
polyploidization,
Agrobacterium-mediated
transformation,
synthetic
seed
production,
cryo-conservation,
omics
approaches.
dedicated
examines
role
nanotechnology
in
utilizing
culminates
a
discussion
on
clinical
applications
human
trials
possessing
molecules.
Lastly,
text
contemplates
future
directions
challenges
field,
emphasizing
potential
avenues
continued
research
advancements
enhancement
