Cytotherapy, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983
Published: March 26, 2024
Language: Английский
Citations
49
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 210, P. 115342 - 115342
Published: May 24, 2024
Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, recognition immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores process, highlighting engagement system, delving into behaviors innate adaptive cells chronic scenarios. Moreover, article investigates biomaterial-based strategies modulation elucidating how adjustment their physicochemical properties or synergistic combination with other agents drugs, proteins mesenchymal stromal can effectively modulate different cells. Finally various based on synthetic biological nanostructures, including extracellular vesicles, finely tune natural immunomodulators therapeutic nanocarriers promising biophysical properties.
Language: Английский
Citations
26
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 7977 - 8006
Published: Jan. 1, 2024
The objective of this review is to provide an up-to-date and all-encompassing account the recent advancements in domain interactive wound dressings. Considering gap between achieved desired clinical outcomes with currently available or under-study healing therapies, newer more specific options based on type phase are reviewed. Starting from comprehensive description process, a detailed classification dressings presented. Subsequently, we present elaborate significant discussion describing (unconventional) Latter includes biopolymer-based, bioactive-containing biosensor-based smart dressings, which discussed separate sections together their applications limitations. Moreover, (2-5 years) trials, patents unconventional marketed products, other information advanced care designs techniques discussed. future research direction highlighted, peptides, proteins, human amniotic membranes as potential Finally, conclude that field needs further development offers scope for integrating process technologies.
Language: Английский
Citations
17
Giant, Journal Year: 2023, Volume and Issue: 16, P. 100185 - 100185
Published: Sept. 1, 2023
Diabetic wounds are difficult to heal due hampered vascularization and tissue regeneration. Wound dressings need frequent replacement guide repair. Here, bio-inks containing sodium alginate (SA), oxidized (OSA), gelatin (Gel) CaCO3 microspheres were prepared. To increase the printability, all pre-crosslinked with calcium ions (Ca2+). Porous hydrogel scaffolds 4.43 ± 0.14 μm2 pore area 184 25 μm line diameter fabricated via 3D printing. After lyophilization swelling in PBS (pH 6.4), SA/OSA/Gel scaffold showed more excellent structural stability than SA SA/Gel, which was attributed Schiff base reaction between OSA Gel. NIH-3T3 cells on proliferated faster better spreading morphology those SA/Gel. placed onto full-thickness SD rat back, guided growth, integrated well regenerated accelerated wound healing, promoted angiogenesis 93.0 2.5% of collagen deposition degraded fragments scaffold. Taken together, porous printing composed SA, OSA, Gel provide a potential strategy improve diabetic healing.
Language: Английский
Citations
15
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575
Published: Sept. 7, 2024
Language: Английский
Citations
5
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: Jan. 31, 2025
Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.
Language: Английский
Citations
0
Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Tissue Viability, Journal Year: 2023, Volume and Issue: 33(1), P. 104 - 115
Published: Nov. 10, 2023
Language: Английский
Citations
5
Critical Reviews™ in Oncogenesis, Journal Year: 2024, Volume and Issue: 29(4), P. 33 - 42
Published: Jan. 1, 2024
Particulate matter (PM) imposes a significant impact to environmental health with deleterious effects on the human pulmonary and cardiovascular systems. Macrophages (Mφ), key immune cells in lung tissues, have prominent role responding inhaled cells, accommodating inflammation, influencing tissue repair processes. Elucidating critical cellular responses of Mφ PM exposure is essential understand mechanisms underlying PM-induced effects. The present review aims give glimpse literature about interaction Mφ, triggering events causing oxidative stress (OS) damage. paper reviews different pathways involved activation upon exposure, including phagocytosis, intracellular signaling cascades, release pro-inflammatory mediators. Potential therapeutic strategies targeting Mφ-mediated reduce are also discussed. Overall, unraveling complex interplay between sheds light new avenues for research promises develop targeted interventions burden PM-related diseases global health.
Language: Английский
Citations
1
Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2024, Volume and Issue: 112(7)
Published: June 24, 2024
Abstract An ideal wound dressing should create a healing environment that relieves pain, protects against infections, maintains moisture, removes debris, and speeds up closure repair. However, conventional options like gauze often fall short in fulfilling these requirements, especially for chronic or nonhealing wounds. Hence there is critical need inventive formulations offer efficient, cost‐effective, eco‐friendly alternatives. This study focuses on assessing the innovative formulation based microbial‐derived copolymer known as poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate), P(3HB‐co‐4HB) bioactive glass graphene particles, exploring their biological response vitro vivo—to find best combination promotes cell adhesion enhances healing. The optimized at concentration of (1 w/w%) (0.01 showed accelerated degradation enhanced blood vessel formation. Meanwhile biocompatibility was evaluated using murine osteoblasts, human dermal fibroblasts, standard culture assays, demonstrating no adverse effects after 7 days well‐regulated inflammatory kinetics. Whole thickness skin defect mice indicated feasibility biocomposites faster reduced inflammation. Overall, this biocomposite appears promising an material positively influencing rates.
Language: Английский
Citations
1