Integrative analysis of the molecular signature of target genes involved in the antitumor effects of cantharidin on hepatocellular carcinoma DOI Creative Commons
Jia Yan,

Yu min Gao,

Xiu ling Deng

et al.

BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 28, 2023

Cantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially hepatocellular carcinoma (HCC). However, a comprehensive analysis CTD-related molecular mechanism still necessary to understand its functions HCC treatment. This study aimed reveal novel targets and regulatory networks CTD HCC.A model H22 tumour-bearing mice was constructed, function tumour growth evaluated. An integrated approach associated transcriptional profiling biological systems identify key regulators involved antitumour pathways. The identified differential expression patterns were supported by results Gene Ontology (GO) term Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyse, protein-protein interaction (PPI) network construction. relationships between gene immunity evaluated using Tumour Immune Estimation Resource (TIMER). Prognostic value analyzed with Kaplan-Meier plotter.In present study, therapeutic effect on vivo. We obtained profiles, systematically intuitively illustrated possible pharmacological mechanisms through signalling These revealed that differentially expressed genes autophagy, transcription factors (TFs) related regulation, fatty acid metabolism immune response HCC. found MAPT, TOP2A, CENPF MEFV hub autophagy regulation. Totally, 14 TFs have confirmed be critical for 33 TF as mis-regulation cancer. cell infiltration. In addition, downregulated significantly enriched metabolic regulation pathways, after Furthermore, miRNAs these metabolism-related constructed HCC.Taken together, our comprehensively elucidated could act therapy, affecting metabolism. Our provide foundation mechanistic clinical application treatment

Language: Английский

Engineered exosomes and composite biomaterials for tissue regeneration DOI Creative Commons
Weikang Hu, Wang Wang, Zesheng Chen

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126

Published: Jan. 1, 2024

Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.

Language: Английский

Citations

25
Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers DOI Creative Commons

Manli Zhou,

Xiaoyun He, Cheng Mei

et al.

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 19, 2023

Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in tumor microenvironment (TME), account for approximately 50% local hematopoietic cells. TAMs play an important role tumorigenesis and development through crosstalk between various cells cytokines TME. Exosomes are small extracellular vesicles with a diameter 50–150 nm, that can transfer biological information (e.g., proteins, nucleic acids, lipids) from secretory to recipient circulatory system, thereby influencing progression human diseases, including cancer. Recent studies have suggested TAMs-derived exosomes crucial roles malignant proliferation, invasion, metastasis, angiogenesis, responses, drug resistance, metabolic reprogramming. potential be targeted therapy. In addition, abnormal expression non-coding RNAs proteins is closely related clinicopathological features patients cancer, these expected become new liquid biopsy markers early diagnosis, prognosis, monitoring tumors. this review, we explored provide diagnostic biomarkers therapeutic targets cancer prevention.

Language: Английский

Citations

36
Causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomisation study DOI Creative Commons
Jingyi Tang,

Shengke Zhang,

Lai Jiang

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(13), P. 4219 - 4231

Published: Jan. 1, 2024

Hepatocellular carcinoma (HCC), the predominant malignancy of digestive tract, ranks as third most common cause cancer-related mortality globally, significantly impeding human health and lifespan. Emerging immunotherapeutic approaches have ignited fresh optimism for patient outcomes. This investigation probes link between 731 immune cell phenotypes HCC through Mendelian Randomization single-cell sequencing, aiming to unearth viable drug targets dissect HCC's etiology.

Language: Английский

Citations

14
The role of exosomes in liver cancer: comprehensive insights from biological function to therapeutic applications DOI Creative Commons
Yinghui Zhang, Congcong Zhang, Nan Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

In recent years, cancer, especially primary liver cancer (including hepatocellular carcinoma and intrahepatic cholangiocarcinoma), has posed a serious threat to human health. the field of exosomes play an important role in initiation, metastasis interaction with tumor microenvironment. Exosomes are class nanoscale extracellular vesicles (EVs)secreted by most cells rich bioactive molecules, including RNA, proteins lipids, that mediate intercellular communication during physiological pathological processes. This review reviews multiple roles progression, as well their effects on angiogenesis, epithelial-mesenchymal transformation (EMT), immune evasion, drug resistance. have great potential biomarkers for diagnosis prognosis because they carry specific molecular markers facilitate early detection evaluation treatment outcomes. addition, exosomes, new type delivery vector, unique advantages targeted therapy provide strategy cancer. The challenges prospects exosome-based immunotherapy were also discussed. However, such standardization isolation techniques scalability therapeutic applications remain significant hurdles.

Language: Английский

Citations

3
The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review DOI Creative Commons
Yanyun Li, Changying Li, Jia Fan

et al.

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 23 - 34

Published: Jan. 1, 2025

Background: Cancer immunotherapy is an advanced therapeutic approach that harnesses the body's immune system to target and eliminate tumor cells. Traditional Chinese medicine (TCM), with a history rooted in centuries of clinical practice, plays crucial role enhancing responses, alleviating cancer-related symptoms, reducing risks infections complications cancer patients. Methodology: This review systematically examines current literature on TCM-based formulations immunotherapy. It explores mechanisms by which TCM augments particularly focusing how these influence both innate adaptive immunity. Various herbs compounds, their active ingredients, application prevention treatment were analyzed through integrated preclinical studies, trials, molecular mechanistic investigations. Results: contribute therapy modulating internal environment improve defense. They enhance system's ability detect destroy cells, promote apoptosis inhibit growth metastasis, augment effectiveness conventional treatments. The highlights specific have demonstrated significant anti-cancer properties, including strengthen responses provide synergistic effects existing therapies. Conclusion: TCM-derived represent promising addition anti-tumor immunity are multifaceted, involving modulation cell activity, induction, suppression progression. As evolves, integration into regimens may offer enhanced efficacy, reduced side effects, improved overall outcomes for Further research needed fully elucidate potential safety immunotherapeutic strategies care. Keywords: traditional medicine, TCM, cancer, nanocarriers, ability, therapy, microenvironment, drug delivery systems

Language: Английский

Citations

0
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-AKT signaling and glycolysis DOI

Xiaoyu Tu,

Wanfu Lin,

Xiaofeng Zhai

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156750 - 156750

Published: April 1, 2025

Language: Английский

Citations

0
Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment DOI Creative Commons

Nada Aakel,

R.A.A. Mohammed,

Afshan Fathima

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)

Published: May 1, 2025

ABSTRACT Background Exosomes are extracellular vesicles ranging from 40 to 100 nm in diameter that mediate intercellular communication by transferring proteins, lipids, nucleic acids, and other metabolites. In the context of cancer, exosomes influence tumor microenvironment carrying regulatory RNAs such as miRNA, circRNA, lncRNA. They originate various cells, including adipocytes, fibroblasts, hepatocellular carcinoma (HCC) can either promote or inhibit cancer progression through pathways like MAPK PI3K‐Akt. Aim This review aims explore role solid cancers, emphasizing their self‐induced activation mechanisms how they modulate behavior. Methodology A comprehensive recent literature was conducted, focusing on studies investigated biological functions progression, molecular cargo, cellular origin, involvement signaling pathways. Results Findings multiple indicate cancer‐derived contribute proliferation, metastasis, therapy resistance enhancing within microenvironment. These activate oncogenic serve biomarkers therapeutic targets due disease modulation. Conclusion play a pivotal offer significant potential advancing our understanding biology. Their capacity key facilitate makes them promising candidates for novel diagnostic strategies.

Language: Английский

Citations

0
A Hypoxia-Related miRNA-mRNA Signature for Predicting the Response and Prognosis of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma DOI Creative Commons
Shaoqi Zong, Guokai Huang, Bo Pan

et al.

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 525 - 542

Published: March 1, 2024

Purpose: Transcatheter arterial chemoembolization (TACE) is commonly used in the treatment of hepatocellular carcinoma (HCC). However, not all patients respond to this treatment. TACE typically leads hypoxia tumor microenvironment. Therefore, we aimed construct a prognostic model based on hypoxia-related differentially expressed microRNA (miRNAs) (HCC) and investigate potential target mRNAs for predicting response. Methods: The miRNAs (HRMs) were identified liver cancer cells, then global test was performed further select which associated with recurrence vascular invasion. A constructed multivariate Cox regression analysis; qRT-PCR analysis validate HCC cell lines under hypoxic condition. We putative genes relationship between response, immune cells infiltration. Results: established HRMs patients, containing two (miR-638, miR-501-5p), high-HRMs score showed worse survival discovery validation cohort; confirmed that these are up-regulated hepatoma Furthermore, four (ADH1B, CTH, FTCD, RCL1), significantly score, immunosuppressive infiltration, PDCD1 CTLA4. Conclusion: HCC-HRMs signature may be utilized as promising factor have implications guiding therapy. Keywords: hypoxia, miRNA, signature, carcinoma, prognosis

Language: Английский

Citations

1
The Effect of Cancer Cell-Derived Exosomal Proteins on Macrophage Polarization: An In-depth Review DOI
Khandu Wadhonkar,

Soumalya Das,

R. Subramanian

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: unknown, P. 114393 - 114393

Published: Dec. 1, 2024

Language: Английский

Citations

1
The role of exosomes in therapeutic resistance of hepatocellular carcinoma DOI Open Access
Jin Wang,

Yali Yang,

Jingyi Lu

et al.

Hepatoma Research, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

Hepatocellular carcinoma (HCC) stands as one of the most prevalent malignant tumors globally. Despite considerable advancements in HCC therapies, therapeutic resistance remains a significant challenge that compromises patient prognosis. Increasing evidence indicates exosomes, which are secreted by cells tumor microenvironment (TME), pivotal players development HCC. These nano-sized vesicles mediate intercellular communication TME through transfer bioactive molecules such nucleic acids, lipids, and proteins. A comprehensive understanding role exosomes could provide promising strategies for both diagnosis treatment This review mainly summarizes involvement exosomal cargos elucidates their underlying mechanisms to treatments HCC, further discusses potential clinical applications diagnostic biomarkers targets overcome drug

Language: Английский

Citations

2