Free Radical Research,
Journal Year:
2023,
Volume and Issue:
58(1), P. 57 - 68
Published: Dec. 25, 2023
Nuclear
factor
erythroid
2-related
2
(Nrf2)
is
an
important
transcriptional
regulator
that
plays
a
protective
role
against
various
cardiovascular
diseases.
Omaveloxolone
newly
discovered
potent
activator
of
Nrf2
has
variety
cytoprotective
functions.
However,
the
potential
omaveloxolone
in
process
pathological
cardiac
hypertrophy
and
heart
failure
are
still
unknown.
In
this
study,
isoproterenol
(ISO)-induced
model
was
established
to
investigate
effect
vivo
vitro.
Our
study
first
confirmed
administration
improved
ISO-induced
mice
neonatal
cardiomyocytes.
also
diminished
oxidative
stress,
inflammation
cardiomyocyte
apoptosis.
addition,
activated
signaling
pathway,
knockdown
almost
completely
abolished
cardioprotective
omaveloxolone,
indicated
directly
related
activation
signaling.
summary,
our
identified
may
be
promising
therapeutic
agent
mitigate
hypertrophy.
Cells,
Journal Year:
2024,
Volume and Issue:
13(17), P. 1488 - 1488
Published: Sept. 5, 2024
Cardiovascular
diseases
remain
the
leading
cause
of
death
in
world,
and
that
is
why
finding
an
effective
multi-functional
treatment
alternative
to
combat
these
has
become
more
important.
Fibrates
thiazolidinediones,
peroxisome
proliferator-activated
receptors
alpha
gamma
are
pharmacological
therapies
used
treat
dyslipidemia
type
2
diabetes,
respectively.
New
mechanisms
action
drugs
have
been
found,
demonstrating
their
pleiotropic
effects,
which
contribute
preserving
heart
by
reducing
or
even
preventing
myocardial
damage.
Here,
we
review
underlying
cardioprotective
effects
PPAR
agonists
regulating
morphological
physiological
alterations
(metabolic
flexibility,
mitochondrial
damage,
apoptosis,
structural
remodeling,
inflammation).
Moreover,
clinical
evidence
regarding
effect
also
addressed.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: May 29, 2024
Background
Taurine,
an
amino
acid
abundantly
found
in
the
brain
and
other
tissues,
has
potential
neuroprotective
properties.
Alzheimer’s
disease
(AD)
is
a
commonly
occurring
type
of
dementia,
which
becomes
more
prevalent
as
people
age.
This
experiment
aimed
to
assess
effects
taurine
on
SH-SY5Y
cells
by
examining
its
impact
Dihydrotestosterone
(DHT),
Dihydroprogesterone
(DHP),
well
expression
miRNA-21
miRNA-181.
Methods
The
various
concentrations
(0.25,
0.75
mg/mL),
LPS
(0.1,
12
mg/mL)
cell
line
were
assessed
using
MTT
assay.
levels
DHT
DHP
quantified
ELISA
kit.
Additionally,
miRNA-181
genes
examined
through
Real-Time
PCR
analysis.
Results
results
assay
showed
that
treatment
with
at
0.25,
mg/mL
reduces
toxicity
cells.
indicated
concentration
significantly
elevated
hormones
compared
untreated
group
(
p
<
0.01).
IL-1β
IL-6
decreased
under
influence
after
(p
Gene
analysis
revealed
increasing
resulted
heightened
miRNA-21,
most
significant
increase
observed
0.001).
Conclusion
Our
study
findings
can
be
enhanced
taurine.
Consequently,
exploring
targeting
taurine,
miRNA-181,
or
considering
hormone
therapy
may
offer
therapeutic
approaches
for
treating
AD
alleviating
severe
symptoms.
Nonetheless,
order
fully
comprehend
precise
mechanisms
involved,
additional
research
required.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 12, 2023
Abstract
Background
Cancer
cells
are
characterized
by
uncontrolled
cell
proliferation
and
impaired
bioenergetics.
Sirtuins
a
family
of
highly
conserved
enzymes
that
play
fundamental
role
in
energy
metabolism
regulation.
SIRT1,
particular,
drives
many
physiological
stress
responses
metabolic
pathways
following
nutrient
deprivation.
We
previously
showed
SIRT1
activation
using
SCIC2.1
was
able
to
attenuate
genotoxic
response
senescence.
Here,
we
report
hepatocellular
carcinoma
(HCC)
under
glucose-deprived
conditions,
treatment
induced
overexpression
SIRT3,
SIRT6,
modulating
response.
Methods
Flow
cytometry
used
analyze
the
cycle.
The
MTT
assay
xCELLigence
system
were
measure
viability
proliferation.
In
vitro
enzymatic
assays
carried
out
as
directed
manufacturer,
absorbance
measured
with
an
automated
Infinite
M1000
reader.
Western
blotting
immunoprecipitation
evaluate
expression
various
proteins
described
this
study.
relative
genes
studied
real-time
PCR.
employed
Seahorse
XF24
Analyzer
determine
state
cells.
Oil
Red
O
staining
lipid
accumulation.
Results
significantly
promoted
mitochondrial
biogenesis
via
AMPK-p53-PGC1α
pathway
enhanced
ATP
production
glucose
inhibition
EX-527
further
supported
our
hypothesis
effects
dependent
on
activation.
Interestingly,
reprogrammed
fatty
acid
oxidation
for
bioenergetic
circuits
repressing
de
novo
lipogenesis.
addition,
SCIC2.1-mediated
strongly
modulated
antioxidant
through
SIRT3
activation,
p53-dependent
indirect
recruitment
SIRT6.
Conclusion
Our
results
show
is
promote
homeostasis,
attenuating
deprivation
SIRT1.
These
findings
shed
light
action
pathogenesis
HCC
may
help
future
therapies
and,
possibly,
other
diseases.
Free Radical Research,
Journal Year:
2023,
Volume and Issue:
58(1), P. 57 - 68
Published: Dec. 25, 2023
Nuclear
factor
erythroid
2-related
2
(Nrf2)
is
an
important
transcriptional
regulator
that
plays
a
protective
role
against
various
cardiovascular
diseases.
Omaveloxolone
newly
discovered
potent
activator
of
Nrf2
has
variety
cytoprotective
functions.
However,
the
potential
omaveloxolone
in
process
pathological
cardiac
hypertrophy
and
heart
failure
are
still
unknown.
In
this
study,
isoproterenol
(ISO)-induced
model
was
established
to
investigate
effect
vivo
vitro.
Our
study
first
confirmed
administration
improved
ISO-induced
mice
neonatal
cardiomyocytes.
also
diminished
oxidative
stress,
inflammation
cardiomyocyte
apoptosis.
addition,
activated
signaling
pathway,
knockdown
almost
completely
abolished
cardioprotective
omaveloxolone,
indicated
directly
related
activation
signaling.
summary,
our
identified
may
be
promising
therapeutic
agent
mitigate
hypertrophy.
