Current Drug Therapy,
Journal Year:
2023,
Volume and Issue:
19(5), P. 561 - 593
Published: Dec. 27, 2023
Abstract:
"Hyaluronic
acid
(HA),
a
non-sulfated
glycosaminoglycan
(GAG),
is
significant
component
of
the
epidermal
extracellular
matrix
(ECM).
It
plays
multiple
roles
in
inflammatory
response,
cell
adhesion,
migration,
proliferation,
differentiation,
angiogenesis,
and
tissue
regeneration.
Due
to
its
inherent
characteristics,
including
non-immunoreactivity,
exceptional
biocompatibility,
biodegradability,
native
biofunctionality,
hydrophilicity,
HA
has
found
applications
production
wound
dressings.
HA's
synergistic
role
enhancing
deeper
penetration
into
chronic
wounds
biofunctional
properties
healing
process
have
been
harnessed.
HA-based
dressings,
often
incorporating
biomolecules
or
drugs
improve
dressing's
biochemical
performance
during
healing,
developed.
In
this
review,
we
explore
current
state
knowledge
regarding
hydrogels
based
on
HA,
focusing
their
delivery
mechanisms.
We
present
latest
developments
research
development
for
treatment
skin
wounds."
Materials & Design,
Journal Year:
2023,
Volume and Issue:
237, P. 112565 - 112565
Published: Dec. 11, 2023
Tissue
engineering
(TE)
has
been
widely
proposed
as
a
potential
solution
to
the
global
shortage
of
donor
organs
for
transplantation.
Organic
and
biocompatible
materials
have
explored
candidates
mimic
natural
extracellular
matrices
regenerative
applications.
Biomimetic
environments
created
using
these
materials,
hydrogels
shown
promise
in
tissue
regeneration
due
their
rapid
gel-forming
ability
excellent
biocompatibility.
Therefore,
achieving
comparisons
between
studies
utilizing
identical
can
prove
arduous,
variations
material
concentrations,
sample
preparation
techniques,
laboratory
conditions
significantly
influence
physicochemical
characteristics
hydrogel
systems.
To
ensure
promotion
clinical
purposes,
stable
variables
are
crucial.
In
this
regard,
we
an
amalgamated
simplified
device
assist
hydrogel-based
systems
hyaluronic
acid
alginate-loaded
exosomes
medicine.
The
objective
study
is
examine
porosity,
injectability,
release
loaded
exosomes,
mechanical
properties,
rate
dissolution
degradation
well-known
biomaterials,
including
alginate
acid,
at
different
concentrations
controlled
setting
provided
by
integrated
device.
Furthermore,
it
aims
comprehensively
assess
ex
vivo
osteogenesis
vascularity-related
metrics.
Biomedical Chromatography,
Journal Year:
2024,
Volume and Issue:
38(5)
Published: Feb. 27, 2024
Abstract
This
study
investigates
the
impact
of
exosomes
on
bone
fracture
healing
in
a
rat
tibial
model,
distinguishing
between
fast
and
slow
processes.
Bone
protein
expression
were
assessed
through
X‐ray
examinations,
hematoxylin
eosin
staining,
immunohistochemical
staining.
Exosomes
isolated,
characterized
subjected
to
liquid
chromatography–mass
spectrometry
for
analysis.
Molecular
differences
explored
using
differentially
expressed
analysis,
Kyoto
Encyclopedia
Genes
Genomes
pathway
enrichment
protein–protein
interaction
networks.
Differential
patterns
expressions
observed
control
model
groups.
successfully
isolated
characterized,
revealing
2004
identified
proteins,
including
distinct
profiles.
Notably,
ribosomal
ferritin
beta‐actin
emerged
as
pivotal
players
healing.
unveils
dynamic
changes
underscores
role
process.
Identified
proteins
pathways
offer
valuable
insights
developing
innovative
therapeutic
strategies
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11873 - 11873
Published: July 24, 2023
Exosomal
regulation
is
intimately
involved
in
key
cellular
processes,
such
as
migration,
proliferation,
and
adhesion.
By
participating
the
of
basic
mechanisms,
extracellular
vesicles
are
important
intercellular
signaling
functioning
mammalian
reproductive
system.
The
complexity
interactions
ovarian
follicle
also
based
on
multilevel
signaling,
including
mechanisms
involving
cadherins,
integrins,
matrix.
processes
ovary
leading
to
formation
a
fertilization-ready
oocyte
extremely
complex
at
molecular
level
depend
oocyte's
ongoing
relationship
with
granulosa
cells.
An
analysis
gene
expression
from
material
obtained
primary
vitro
culture
porcine
cells
was
employed
using
microarray
technology.
Genes
highest
(LIPG,
HSD3B1,
CLIP4,
LOX,
ANKRD1,
FMOD,
SHAS2,
TAGLN,
ITGA8,
MXRA5,
NEXN)
lowest
levels
(DAPL1,
HSD17B1,
SNX31,
FST,
NEBL,
CXCL10,
RGS2,
MAL2,
IHH,
TRIB2)
were
selected
for
further
analysis.
results
microarrays
validated
quantitative
RT-qPCR.
Exosomes
may
play
roles
regarding
between
Therefore,
exosomes
have
significant
applications
regenerative
medicine,
targeted
therapy,
assisted
reproduction
technologies.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Nanocomposite
hydrogels
offer
a
promising
approach
to
treating
diabetic
wounds.
Key
findings
include
enhanced
mechanical
properties,
antibacterial
effects,
and
the
ability
regulate
wound
microenvironment.
Current Drug Therapy,
Journal Year:
2023,
Volume and Issue:
19(5), P. 561 - 593
Published: Dec. 27, 2023
Abstract:
"Hyaluronic
acid
(HA),
a
non-sulfated
glycosaminoglycan
(GAG),
is
significant
component
of
the
epidermal
extracellular
matrix
(ECM).
It
plays
multiple
roles
in
inflammatory
response,
cell
adhesion,
migration,
proliferation,
differentiation,
angiogenesis,
and
tissue
regeneration.
Due
to
its
inherent
characteristics,
including
non-immunoreactivity,
exceptional
biocompatibility,
biodegradability,
native
biofunctionality,
hydrophilicity,
HA
has
found
applications
production
wound
dressings.
HA's
synergistic
role
enhancing
deeper
penetration
into
chronic
wounds
biofunctional
properties
healing
process
have
been
harnessed.
HA-based
dressings,
often
incorporating
biomolecules
or
drugs
improve
dressing's
biochemical
performance
during
healing,
developed.
In
this
review,
we
explore
current
state
knowledge
regarding
hydrogels
based
on
HA,
focusing
their
delivery
mechanisms.
We
present
latest
developments
research
development
for
treatment
skin
wounds."
