Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(12)
Published: Dec. 1, 2024
Objectives
Tang
Du
Qing
granules,
a
traditional
Chinese
medicine
for
diabetes,
may
alleviate
insulin
resistance
induced
by
persistent
organic
pollutant
exposure.
This
study
aims
to
explore
the
mechanism
which
granules
improve
in
rats
exposed
PCB126.
Methods
Male
ZDF
(fa/fa)
were
divided
into
PCB126-exposed
group
and
model
control
group.
(fa/+)
served
as
normal
Normal
controls
received
regular
diet
with
olive
oil
via
gavage,
while
special
feed
oil.
PCB126
8
weeks.
Post-exposure,
positive
drug
treatment
CH223191,
administered
at
high,
medium,
low
doses
4
Relevant
biochemical
indicators
molecular
signaling
changes
assessed.
Results
exposure
increased
levels
of
FBG,
FINS,
HOMA-IR
elevated
serum
TG,
TC,
FFA
compared
(
P
<
.05).
The
Qing-treated
showed
decreased
levels,
reduced
Additionally,
downregulated
hepatic
AhR,
CD36,
TNFα
expression,
upregulating
PPARα,
PPARγ,
GLUT4,
FGF21
expression
Conclusion
ameliorate
glucose
lipid
toxicity
modulating
imbalance
between
AhR
PPARs
related
signals.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 3, 2024
Diphenyl
diselenide
(DPDS)
ameliorates
nephropathy
in
streptozotocin
(STZ)-induced
type
1
diabetic
rats
by
inhibiting
oxidative
stress
and
inflammatory
reactions.
However,
it
has
not
been
clarified
whether
DPDS
alleviates
kidney
disease
(DKD)
is
related
to
the
inhibition
of
extracellular
matrix
(ECM)
production
regulation
intestinal
flora
disorder.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 12, 2024
Diarrhea
is
a
common
clinical
condition
that
can
potentially
be
fatal.
Current
treatment
options
often
have
side
effects,
such
as
constipation
and
vomiting,
there
remains
need
for
more
effective
therapies.
Pickled
vegetables,
famous
traditional
food
in
China,
been
suggested
studies
to
alleviate
diarrhea
children,
particularly
through
the
use
of
pickle
water
(PW).
However,
pharmacological
effects
mechanisms
PW
on
intestinal
health
remain
unclear.
This
study
aimed
explore
protective
castor
oil-induced
ICR
mice
investigate
its
potential
mechanisms.
Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(10)
Published: Oct. 1, 2024
Background
of
the
study
This
established
antidiabetic
efficacy
Alternantera
brasiliana
in
vitro
and
vivo,
identified
most
active
fraction
profiled
chemical
constituents
fraction.
Methodology
The
leaf
A.
was
air-dried,
pulverized
extracted
with
methanol
evaluated
for
its
α-amylase
activity
at
different
concentrations
using
method.
vivo
extract
glibenclamide
glucose
loaded
streptozotocin-induced
diabetic
rats
various
doses,
while
partitioned
method
followed
by
identification
through
GC-MS
analysis.
Results
elicited
good
inhibitory
potential
IC
50
=
0.45
mg/mL.
Also,
mg/kg
dose
demonstrated
highest
percentage
blood
level
reduction
significantly
(
P
>
0.05)
comparable
to
(5
mg/kg)
from
0.5
4
h.
assay
showed
that
better
than
on
days
10
14.
aqueous
53%
secondary
metabolite
profiling
30
compounds
whereby
1H-Indole-2-carboxylic
acid,
6-(4-ethoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-,
isopropyl
ester,
Benzo[h]quinoline,
2,4-dimethyl-,
thymol
13,5-trioxane
as
major
constituents.
Conclusion
