Journal of Blood Medicine,
Journal Year:
2024,
Volume and Issue:
Volume 15, P. 523 - 531
Published: Dec. 1, 2024
Gallbladder
adenocarcinoma
has
a
high
mortality
rate,
with
approximately
1.7%
cancer-related
deaths
worldwide.
Cancer-associated
thrombosis
(CAT),
including
deep
vein
(DVT),
can
significantly
increase
the
risk
of
within
cancer
patients,
especially
in
pancreatic,
brain,
and
intra-abdominal
cancers,
as
well
advanced
metastatic
cancers.
In
this
case
report,
there
was
45-year-old
male
patient
diagnosed
gallbladder
UICC
stage
IVB
TNM
T2b,
N0,
M1
liver
metastases
who
experienced
pain
swelling
both
lower
limbs
after
undergoing
VI-A
cycle
chemotherapy
gemcitabine
capecitabine.
The
calculated
using
modified
Khorana-Vienna
CAT
scores,
which
increased
during
every
session.
case,
score
two
latest
that
somewhat
considered
delayed
had
already
shown
hypercoagulopathy
symptoms
developed
poorer
prognosis.
Early
scoring,
ideally
before
starting
session,
potentially
improves
patient's
condition
improved
administration
antithrombotic
agents.
Chemotherapy
agents
other
factors,
site
presence
cancer,
influence
CAT.
Risk
predictor
scores
are
required
to
assess
benefits
prophylactic
treatment.
Prophylactic
therapy
be
initiated
patients
high-risk
CAT,
Khorana
Vienna
prevent
improve
outcomes.
Doctor Ru,
Journal Year:
2024,
Volume and Issue:
23(1), P. 46 - 50
Published: Jan. 1, 2024
Aim.
To
analyze
current
data
on
the
incidence,
risk
factors,
diagnostic
methods
and
prevention
of
gallbladder
cancer
(GBC).
Key
points.
GBC
is
a
malignant
tumor
arising
from
epithelium
gallbladder,
characterized
by
local
vascular
invasion,
extensive
regional
lymphogenous
hematogenous
metastasis.
most
common
biliary
tract,
high
malignancy
low
5-year
survival
rate.
In
international
recommendations,
gastrointestinal
tract
considered
as
natural
stage
course
pathology:
dyskinesia
—
cholecystitis
cholelithiasis
GBC.
Globally,
incidence
varies
significantly
among
different
geographic
regions,
reaching
27
per
100,000
population
in
Chile.
Russia,
according
to
Federal
State
Statistics
Service,
2019
was
1.4
100
thousand
men,
2.5
women.
The
associated
with
female
gender
increasing
age.
pathogenesis
gallstones,
decisive
importance
attached
long-term
inflammatory
changes
due
mechanical
trauma
mucous
membrane
stones
probable
increase
proportion
secondary
bile
acids
bile.
diagnosis
GBC,
recommendations
Japanese
Society
Hepato-Biliary-Pancreatic
Surgery,
first
step,
particular
ultrasound
examination
abdominal
organs
biochemical
blood
test.
For
more
detailed
study,
computed
tomography,
magnetic
resonance
imaging,
cholangiopancreatography,
endosonography,
retrograde
oral
cholangioscopy
positron
emission
tomography
are
useful.
Gallstone
disease
one
five
significant
factors.
remaining
4
leading
factors
for
ethnicity,
genetic
predisposition,
lifestyle
(excess
weight)
infections
patients
cholelithiasis.
developing
increases
larger
than
2
cm
duration
pathology
5
years.
Another
factor
polyps,
therefore
article
presents
main
European
associations
management
polyps.
Conclusion.
currently
possible
Considering
above,
complications
elderly
gallstone
should
include
thorough
clinical,
laboratory
instrumental
examination.
Preventive
measures
people
optimizing
diet,
weight
loss,
and,
if
possible,
expanding
physical
activity
regime.
Taking
ursodeoxycholic
acid
preparations
helps
reduce
content
hydrophobic
reduces
likelihood
pathology.
Keywords:
cancer,
cholelithiasis,
diagnosis,
morbidity.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 13, 2024
Purpose
Treatment
for
advanced
gallbladder
cancer
(GBC)
remains
controversial,
with
various
recommendations
regarding
the
choice
and
combination
of
surgery
adjuvant
therapy.
The
present
article
is
targeting
exploration
optimal
treatment
models
GBC.
Methods
AJCC
(American
Joint
Committee
on
Cancer,
8th
edition)
stage
III
IV
GBC,
were
defined
as
Patients
GBC
identified
using
Surveillance,
Epidemiology,
End
Results
(SEER)
database
departmental
cohort.
Because
most
representative,
only
adenocarcinoma
(GBAC)
patients
selected.
Based
their
surgical
status
(No,
Non-radical
Radical
surgery),
chemotherapy
(Chemotherapy,
No
chemotherapy),
radiotherapy
(Radiotherapy,
radiotherapy),
categorized.
For
purposes
evaluating
outcomes
determining
risk
element
cancer-specific
survival
(CSS),
Cox
regression
analysis
was
applied.
Kaplan-Meier
curves
used
before
after
adjusting
covariates,
log-rank
tests
to
analyze
discrepancies
between
curves.
Immunotherapy
analyzed
clinical
data
from
Finally,
compensate
limitations
database,
a
review
examines
progress
in
5,154
aged
over
18
years
solitary
primary
SEER
database.
In
patients,
model
has
emerged
significant
prognostic
factor.
“Radical
+
Chemotherapy
Radiotherapy”
maximally
improved
CSS
while
“No
radiotherapy”
had
lowest
CSS.
conclusions
supported
even
subgroup
by
stage.
efficacy
immunotherapy
demonstrated
cohort
analysis.
Additionally,
this
provides
comprehensive
overview
recent
advancements
emerging
strategies.
Conclusion
Even
when
cannot
be
pursued,
providing
combinations
treatments
whenever
possible
always
beneficial
survival.
Journal of Blood Medicine,
Journal Year:
2024,
Volume and Issue:
Volume 15, P. 523 - 531
Published: Dec. 1, 2024
Gallbladder
adenocarcinoma
has
a
high
mortality
rate,
with
approximately
1.7%
cancer-related
deaths
worldwide.
Cancer-associated
thrombosis
(CAT),
including
deep
vein
(DVT),
can
significantly
increase
the
risk
of
within
cancer
patients,
especially
in
pancreatic,
brain,
and
intra-abdominal
cancers,
as
well
advanced
metastatic
cancers.
In
this
case
report,
there
was
45-year-old
male
patient
diagnosed
gallbladder
UICC
stage
IVB
TNM
T2b,
N0,
M1
liver
metastases
who
experienced
pain
swelling
both
lower
limbs
after
undergoing
VI-A
cycle
chemotherapy
gemcitabine
capecitabine.
The
calculated
using
modified
Khorana-Vienna
CAT
scores,
which
increased
during
every
session.
case,
score
two
latest
that
somewhat
considered
delayed
had
already
shown
hypercoagulopathy
symptoms
developed
poorer
prognosis.
Early
scoring,
ideally
before
starting
session,
potentially
improves
patient's
condition
improved
administration
antithrombotic
agents.
Chemotherapy
agents
other
factors,
site
presence
cancer,
influence
CAT.
Risk
predictor
scores
are
required
to
assess
benefits
prophylactic
treatment.
Prophylactic
therapy
be
initiated
patients
high-risk
CAT,
Khorana
Vienna
prevent
improve
outcomes.
