Published: Oct. 27, 2023
Language: Английский
Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 210 - 210
Published: April 7, 2024
The irrational use of antibiotics has favored the emergence resistant bacteria, posing a serious threat to global health. To counteract antibiotic resistance, this research seeks identify novel antimicrobials derived from essential oils that operate through several mechanisms. It aims evaluate quality and composition Origanum compactum elongatum; test their antimicrobial activity against various strains; explore synergies with commercial antibiotics; predict efficacy, toxicity, stability compounds; understand molecular interactions docking dynamic simulations. were extracted via hydrodistillation flowering tops oregano in Middle Atlas Mountains Morocco. Gas chromatography combined mass spectrometry (GC-MS) was used examine composition. Nine common chosen tested alone or combination discover synergistic effects clinically important bacterial strains. A comprehensive silico study conducted, involving dynamics simulations (MD). O. elongatum oil includes borneol (8.58%), p-cymene (42.56%), thymol (28.43%), carvacrol (30.89%), whereas is mostly composed γ-terpinene (22.89%), (15.84%), (10.21%), (E)-caryophyllene (3.63%). With proving be most potent, these showed antibacterial action both Gram-positive Gram-negative bacteria. Certain antibiotics, including ciprofloxacin, ceftriaxone, amoxicillin, ampicillin, have been shown elicit effects. fight elongatum, particularly those high (E)-caryophyllene, seem promising when antibiotics. These could result ability target same proteins facilitate access sites, as suggested by Molecular validated examined protein–ligand complexes, emphasizing propensity substances like for particular proteins, opening door potentially effective new therapeutic approaches pathogens multiple drugs.
Language: Английский
Citations
16
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: April 10, 2024
Abstract Strain-specific probiotics can present antioxidant activity and reduce damage caused by oxidation. Streptococcus alactolyticus strain FGM ( S. FGM) isolated from the chicken cecum shows potential probiotic properties which have been previously demonstrated. However, of remain unknown. In this view, cell-free supernatant (CFS), intact cells (IC) intracellular extracts (CFE) 3 strains Lactobacillus LAB ) were prepared, their scavenging capacities against DPPH, hydroxyl radicals linoleic acid peroxidation inhibitory compared in study. The effects (FCFS) on NO production, SOD GSH-Px RAW264.7 LPS-induced analyzed. metabolites quantitated N300 Quantitative Metabolome. It was shown that physicochemical characteristics CFS to scavenge radicals, significantly stronger than IC CFE P < 0.05), respectively 87.12% ± 1.62, 45.03% 1.27, 15.63% 1.34. FCFS had a promotional effect cells, elevated activities cells. 25 μL promoted proliferation induced LPS, increased GSH-PX, decreased release NO. Furthermore, among differential quantified N300, 12 up-regulated, including lactic acid, indole pyruvic etc., many are known with properties. conclusion, good activity, be attributed produced fermentation. further confirmed its postbiotic bright application prospects livestock poultry breeding.
Language: Английский
Citations
10
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 31, 2024
Abstract Satureja is an aromatic plant that used for flavoring, perfume, and food manufacturing due to its pleasant essential oil. Modern medicine research revealed several biological activities of oil, including antifungal, antibacterial, antiviral, antioxidant, anticancer, anti-inflammatory. However, the functional properties fatty acid have not been explored. This study examined profile, lipid nutritional quality, anti-amylase, anti-lipase capacities . The efficiency on anti-oxidative anti-inflammatory parameters in LPS-induced macrophage through Nrf2/NF-kB/NADH oxidase pathway was examined. whole extract prepared with chloroform/methanol/water solution. Fatty acids methyl ester from were methanol/sulfuric reagent. profile analyzed using gas chromatography-mass spectrometry. Total antioxidant determined by ABTS decolorization. Lipase amylase monitoring decomposition p -nitrophenyl butyrate starch. cell line grown DMEM media presence acid. hydrogen peroxide production treated cells monitored FOX NADH activity measured breakdown. expression NOX, NF-kB, NRF2, tested real-time PCR. main components linolenic (24.67–37.32%), palmitic (10.65–20.29%), linoleic (8.31–13.39%), oleic (4.42–14.35%), stearic (2.76–8.77%) palmitoleic (1.77–4.95%). Given omega-3 PUFA (23.58–37.32%), SFA (21.53–26.70%), omega-6 (10.86–16.14%), omega-9 MUFA omega-7 (1.77–4.95%) comprise majority acids. has a promising unsaturation index (120.77–164.27), PUFA/MUFA (2.07–6.41), hypocholesterolemic (2.44–3.47), health-promoting (2.03–2.42), PUFA/SFA (1.37–1.94), nutritive value (0.53–1.71), MUFA/SFA (0.30–0.80) omega-6/omega-3 (0.34–0.65), atherogenicity (0.41–0.49), thrombogenicity (0.17–0.27). displayed strong capacity (with IC 50 ranging 354 428 µg/mL), anti-amylase 370 390 µg/mL). LPS induced NF-kB synthesis cells. In LPS-stimulated macrophages, reduced NOX expression, peroxide, increased NRF2 at 0.04 mg/mL. conclusion, potent anti-lipase, activities. mechanisms lowering oxidative stress markers depended down-regulating superoxide-producing enzymes gene protein levels. polyunsaturated could be recommended healthy products combined dietary therapy treat obesity, diabetes, stress.
Language: Английский
Citations
5
Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1304 - 1304
Published: March 14, 2025
Many aromatic herbs are conventionally used for flavoring various foods, but receive wide attention because of the variety health-related properties. The can be either fresh or as dried powders and in form extracts, essential oils, purified metabolites. In this review, main functional properties, terms antioxidant antimicrobial applications some commonly from Lamiaceae family, discussed. Herbs like oregano, rosemary, sage, thyme, summer savory, marjoram, basil possess high levels bioactive phytochemicals. They particularly rich phenolic acids, flavones, diterpenes, flavanones, with beneficial effects. phytochemical profile plants is highly influenced by genetic factors, environmental conditions, their interaction. cases extracts extraction method has a strong effect on final composition herb products. Most these related to antioxidant, antimicrobial, particular, oils have multiple fields food, feed, pharmaceutical, cosmetics, biopesticides, textile industries.
Language: Английский
Citations
0
Fırat Üniversitesi Mühendislik Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 37(1), P. 487 - 508
Published: March 14, 2025
This study was conducted to investigate the traditional medicinal plants used by local people in order treat various types of respiratory disorders Dereboğazı village (Erzurum). The present ethnomedical (Palandöken, Erzurum - East Anatolia), between 2019-2020 years. Information on ethnobotanical use plant taxa were gathered through in-person interviews with and recorded using a questionnaire form. In gather data, 63 informants—16 men 47 women—participated study. Samples prepared placed Herbarium Karadeniz Technical University Faculty Forestry (KATO). reported 32 native exotic vascular from 13 families 24 genera being ethnomedicinally for treating problems such as asthma, bronchitis, common cold, cough, flu sore throat. most method therapeutic purposes is decoction (23 taxa). As result study, highest number Lamiaceae (9 taxa), Rosaceae (6), Asteraceae Moraceae (3). commonly parts identified aerial (13 fruits (8 leaves dried (7 taxa) flowers (6 similar studies, which include information biological resources, will contribute field pharmacy medical science.
Language: Английский
Citations
0
Pesquisa Agropecuária Tropical, Journal Year: 2025, Volume and Issue: 55
Published: Jan. 1, 2025
ABSTRACT Nutrition is essential to optimize the quantitative and qualitative performance of medicinal plants, as well prevent biotic abiotic stresses. This study aimed evaluate effect seaweed extract [Ascophyllum nodosum; non-application, soil application (SA), foliar (FA) SA + FA] chemical fertilizers (application non-application) on yield, oil content compounds savory, in a factorial experiment based randomized complete block design. A significant increase was observed savory dry weight yield under fertilizer FA, being highest matter obtained with (SA FA) fertilizer. There correlation between weight, percentage. The carvacrol increased extract. use an organic has potential savory.
Language: Английский
Citations
0
Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(35), P. 47757 - 47770
Published: July 15, 2024
Citations
3
Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 17(2), P. 105547 - 105547
Published: Dec. 11, 2023
The primary environmental factor affecting the biochemical attributes of plants is soil pollution by heavy metals. detrimental effects metals on can be lessened amendments. goal current research was to determine potential biochar (BC) and vermicompost (VC) as amendments in reducing Pb toxicity summer savory (Satureja Hortensis L.) though physiological modifications. Therefore, pot experiment conducted with (control (non-Pb), 300, 600 mg kg soil-1) (control, 2% BC, 10% VC, 1% BC+5% VC) based a completely randomized design. results showed that at soil-1 led significant decreases shoot weight (41%), root (25%), leaf relative water content (20%), chlorophyll (39%) compared control. However, it resulted increases malondialdehyde (61%) electrolyte leakage (49%) when BC VC were not applied. (39%), but (61%), control treatments without application. particularly their combination more effective improving plant growth. interaction 300 kg-1 combined higher total phenolic content, flavonoid essential oil (EO) EO yield 29, 62, 39, 35% raises Agglomerative hierarchical clustering revealed differed from control, significantly varied individual values. Combining than using them separately alleviating toxicity, enhances growth secondary metabolite production. have benefit improvement resistance Pb-polluted soils.
Language: Английский
Citations
5
Plants, Journal Year: 2023, Volume and Issue: 12(24), P. 4114 - 4114
Published: Dec. 8, 2023
Satureja pilosa Velen. (Lamiaceae) is a perennial and melliferous aromatic-medicinal subshrub which range-restricted in adjacent parts of Greece Bulgaria locally Italy, known Northern as wild oregano ("agriorigani") traditionally collected from the for culinary purposes. Since ethnopharmacological data modern biological activities spp. suggest promising applications skin conditions, present study aimed to investigate hitherto unknown phenolic content cultivated S. its potential activities, focusing mainly on wound-healing anti-inflammatory effects. An HPLC-PDA-MS-targeted phytochemical investigation, along with NMR, allowed isolation characterization main constituents, resulting 18 compounds. Representative extracts purified compounds were tested activity NIH/3T3 fibroblasts. The butanol extract exhibited significantly higher cell migration rate (73.4%) compared aqueous (50.6%) methanolic (49.6%) ones, enhancing more rapidly at both concentration levels, whilst rosmarinic acid was most potent among isolated compounds, 64.0% level 10-5 mg/mL, followed by 3,4-dihydrophenyllactic (54.7%). Moreover, effects endothelial activation processes explored, including leukocyte-endothelial interaction during inflammatory migratory capacity angiogenic actions, since these are commonly associated diseases. Finally, demonstrated weak antibacterial against two important pathogens (Staphylococcus aureus Pseudomonas aeruginosa), suggesting that further investigation warrented.
Language: Английский
Citations
5
BMC Plant Biology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 17, 2024
The use of lanthanum (La) as a rare element has increased in agriculture. Summer savory (Satureja hortensis L.) is an herbaceous and medicinal plant that received attention recently. present study aimed to investigate the effects foliar application zinc (Zn), copper (Cu), manganese (Mn), La at different growth stages, including vegetative, reproductive, vegetative harvest on morphological physiological traits S. under hydroponic soil conditions greenhouse. was arranged factorial experiment based completely randomized design (CRD) with three replications.
Language: Английский
Citations
1