The effect of copper acetate on hepatocyte metabolism in vitro DOI Creative Commons
I. S. Trukhan, Н. Н. Дремина, И. А. Шурыгина

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2024, Volume and Issue: 9(6), P. 12 - 21

Published: Dec. 28, 2024

Background . Copper ions are necessary for maintaining basic physiological processes in the mammalian organism. However, their excessive absorption or accumulation cells can lead to development exacerbation of various pathological processes. The cytotoxic and genotoxic effects high concentrations copper compounds currently well studied cell cultures, whereas effect non-toxic amounts on cells, including during cultivation, has been extremely poorly studied. aim study To investigate changes intracellular amount mitochondrial cytochrome C oxidase glutathione synthetase. Materials methods A primary culture hepatocytes was obtained, which exposed acetate at a concentration 200 µg/ml terms content 24 hours. After fixation, samples were stained immunocytochemically using antibodies (CcO) subunit I synthetase (GS). Results In hepatocyte culture, significant increase intensity fluorescent staining two analyzed enzymes demonstrated both after 6 hours exposure ions, indicates change number cells. At same time, CcO more intense first incubation with microelement, next 18 hours, less pronounced. GS stain active observed throughout entire cultivation period. Conclusion From results it be concluded that able influence key indicators viability by changing one main energy metabolism enzyme provides synthesis most important low-molecular antioxidant glutathione.

Language: Английский

Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy DOI Open Access

Chloe Springer,

Danish Humayun,

Rachid Skouta

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 647 - 647

Published: Feb. 2, 2024

Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced death, known as cuproptosis, its disease implications, including cancer therapy. Copper ionophores, such elesclomol disulfiram, increase intracellular copper levels. elevation triggers oxidative stress subsequent offering implications in Additionally, ionophores disrupt mitochondrial respiration protein lipoylation, further contributing toxicity death. Potential targets biomarkers are identified, can be targeted those proteins trigger cuproptosis. The role different cancers is discussed understand therapies using nanomaterials, chelators. Furthermore, explored through diseases Wilson Menkes physiological copper. Exploring cuproptosis presents opportunity improve treatments copper-related disorders cancers, with bring significant advancements modern medicine.

Language: Английский

Citations

24
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review DOI Creative Commons

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

Citations

24
Cuproptosis in cancers: Function and implications from bench to bedside DOI Open Access

Xin-Yi Huang,

Jia-Yang Shen,

Ke Huang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116874 - 116874

Published: June 7, 2024

Copper, an indispensable micronutrient, is implicated in numerous vital biological processes and essential for all physiological activities. Recently, the discovery of a novel type copper-dependent cell death, known as cuproptosis, has shed light on its role cancer development. Extensive research currently underway to unravel mechanisms underlying cuproptosis correlation with various types. In this review, we summarize findings regarding roles types, including colorectal cancer, lung gastric breast liver cutaneous melanoma. Furthermore, effects copper-related agents such copper chelators ionophores proliferation, apoptosis, angiogenesis, tumor immunity, chemotherapy resistance have been explored preclinical clinical trials. These insights provide promising avenues development prospective anticancer drugs aimed at inducing cuproptosis.

Language: Английский

Citations

5
Identification of Key lncRNAs in Gout Under Copper Death and Iron Death Mechanisms: A Study Based on ceRNA Network Analysis and Random Forest Algorithm DOI

Zichen Shao,

Weikang Sun, Qinqin Deng

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Language: Английский

Citations

4
Construction of a novel cuproptosis-related gene signature and integrative analyses in cholangiocarcinoma DOI Creative Commons

Liye Wang,

Pan Li, Shuai Gong

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41600 - e41600

Published: Jan. 1, 2025

Language: Английский

Citations

0
U‐Shaped Association Between Dietary Copper Intake and New‐Onset Chronic Kidney Disease: A 30‐Year Follow‐Up Study From Young Adulthood to Midlife DOI Open Access
Yiwei Zhang, Xiaoqin Gan, Hao Xiang

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The relationship of dietary copper intake with new-onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association CKD in a 30-year follow-up study from young adulthood midlife. A total 4038 U.S. adults aged 18-30 years and without reduced estimated glomerular filtration rate (eGFR) Coronary Artery Risk Development Young Adults (CARDIA) was included. During follow-up, 642 (15.9%) participants developed CKD. Overall, there U-shaped between (p for nonlinearity = 0.034). When assessed as quartiles, compared those second quartile (2.03-<2.46 mg/day), adjusted hazard ratios (HRs) (95% confidence interval [CI]) were 1.29 (1.05, 1.66), (1.02, 1.64), 1.49 (1.16, 1.91) first (<2.03 third (2.46-<3.11 fourth (≥3.11 mg/day) respectively. Similar associations observed eGFR decline albuminuria. There CKD, lowest risk at 2.03-<2.46 mg/day. Emphasizing importance maintaining optimal levels primary prevention

Language: Английский

Citations

0
Copper-chelating natural products DOI
Olivia M. Manley, Amy C. Rosenzweig

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Targeting mineral metabolism in cancer: Insights into signaling pathways and therapeutic strategies DOI

Kartik Bhatnagar,

Sharon Raju,

Ninad Patki

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Precision Medicine in High-Grade Serous Ovarian Cancer: Targeted Therapies and the Challenge of Chemoresistance DOI Open Access

Sara Polajžer,

Katarina Černe

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2545 - 2545

Published: March 12, 2025

The poor prognosis for high-grade serous ovarian cancer (HGSOC), the dominant subtype of cancer, reflects its aggressive nature, late diagnosis, and highest mortality rate among all gynaecologic cancers. Apart from main reason unsuccessful treatment is primarily emergence chemoresistance to carboplatin. Although there a good response primary treatment, disease recurs in 80% cases, at which point it largely resistant introduction novel targeted therapies second decade 21st century has begun transform HGSOC, although their impact on overall survival remains unsatisfactory. Targeting specific pathways known be abnormally activated HGSOC especially difficult due molecular diversity subtypes. Moreover, range changes are associated with acquired chemoresistance, e.g., reversion BRCA1 BRCA2 germline alleles. In this review, we examine advantages disadvantages approved therapies, including bevacizumab, PARP inhibitors (PARPis), treatments targeting cells neurotrophic tyrosine receptor kinase (NTRK), B-rapidly accelerated fibrosarcoma (BRAF), rearranged during transfection (RET) gene alterations, as well antibody–drug conjugates. Additionally, explore promising new targets under investigation ongoing clinical trials, such immune checkpoint inhibitors, anti-angiogenic agents, phosphatidylinositol-3-kinase (PI3K) Wee1 ataxia telangiectasia Rad3-related protein (ATR) platinum-resistant disease. Despite development carboplatin fundamental medicine therapy. correct choice strategy better patients advanced should therefore include prediction patients’ risks developing platinum-based chemotherapy. effective therapy requires selection who likely derive benefit while minimizing potential adverse effects, underscoring essence precision medicine.

Language: Английский

Citations

0
An up‐To‐Date Review of Elesclomol and Its Nano‐Formulations in Cancer Therapy DOI Creative Commons
Qi Wang, Feng Li, Amit K. Tiwari

et al.

Cancer Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

ABSTRACT Background Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as copper (Cu(II)) ionophore, forming an ES–Cu complex within cancer cells and inducing novel form of cell death called cuproptosis. Aim To provide up‐to‐date review on elesclomol nano‐formulations with particular focus therapy. Sources Literature was collected by manually searching in Pubmed, Google Scholar, clinicaltrials.gov March 2025. Content This provides overview the discovery development ES molecule, including physicochemical properties. New insights into intracellular interactions mechanisms transportation are then explained. The recent clinical outcomes therapy, both monotherapy combination paclitaxel or carboplatin, summarized. While initial trials showed promise, more studies focusing preclinical investigations complex. Nanomedicine‐based formulations have emerged strategy to enhance delivery well therapeutic effects, several nanomedicines currently under development. nanoparticle strategies discussed. comprehensive advancements study, mechanism action, progress, potential nanomedicine‐based approaches improve efficacy treatment.

Language: Английский

Citations

0