Modification of Cotton with Chitosan: Deposition of Copper(II) Sulfate by Complexation Copper Ions DOI Open Access
Małgorzata Świerczyńska,

Zdzisława Mrozińska,

Michał Juszczak

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2772 - 2772

Published: Dec. 5, 2024

This study introduces a novel approach for enhancing the functional properties of cotton fibers through complexation copper sulfate, and subsequent combination with chitosan (COT-CuSO4-CTS). Our preliminary investigations focused on development composites as candidate materials coatings antimicrobial properties. The were thoroughly characterized via scanning electron microscopy (SEM) optical microscopy, providing insights into their structural features composition. findings show that modified exhibit potent activity. Specifically, COT-CuSO4 COT-CuSO4-CTS samples demonstrated zones inhibition against both Gram-positive Staphylococcus aureus Gram-negative Escherichia coli, confirming ability to reduce microbial growth significantly. incorporation layer significantly enhanced Ultraviolet Protection Factor (UPF) fabric from 3.37 over 50, indicating exceptional UV shielding capabilities, while copper(II) oxide treatment provided moderate UPF value 14.56. Blood compatibility studies further revealed fabrics influence coagulation parameters, marked prolongation in activated partial thromboplastin time (aPTT) prothrombin (PT) compared untreated cotton. anticoagulant effect is primarily linked presence copper, although addition modulates this response, slightly reducing clotting times alone. Cytotoxicity genotoxicity assessments using Peripheral Mononuclear (PBM) cells indicated was non-toxic non-genotoxic. However, displayed reduction cell viability induced DNA damage, highlighting potential cytotoxic genotoxic effects. Notably, showed lower cytotoxicity than COT-CuSO4-CTS, suggesting reduces overall composite. Furthermore, plasmid relaxation assays interact DNA, exhibiting stronger interaction consistent PBM cells.

Language: Английский

Cuproptosis: unveiling a new frontier in cancer biology and therapeutics DOI Creative Commons

Ying Feng,

Zhibo Yang,

Jianpeng Wang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 1, 2024

Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.

Language: Английский

Citations

19
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

9
Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease DOI Creative Commons
Yun Mao, Huilan Chen,

Weihan Zhu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 883 - 894

Published: Jan. 1, 2025

Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is fourth cancer-related mortality, representing a substantial risk to public health. Over past few decades, global landscape chronic diseases, including hepatitis, metabolic dysfunction-associated steatotic (MASLD), fibrosis, and HCC, has undergone changes. Copper, vital trace element for human health, predominantly regulated by liver. Both copper deficiency excess can lead cellular damage dysfunction. Copper deposition genetic process copper-dependent cell associated with mitochondrial respiration, which cardiovascular IBD. However, roles overload cuproptosis in remain largely underexplored. This article examines recent studies on metabolism disease, investigating potential targeting ions therapeutic approach. The objective offer insights guidance future investigations this developing field study.

Language: Английский

Citations

1
The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials DOI Open Access

Irfan Mehmud,

Song Wu, Shaohua Zhang

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Language: Английский

Citations

1
Copper homeostasis and cuproptosis in health and disease DOI Creative Commons

Yunuo Yang,

Jiaxuan Wu,

Lisheng Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 17, 2024

Copper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation various biological processes. Regulation copper levels within narrow range imperative maintaining homeostasis. Numerous studies have demonstrated significant roles homeostasis cuproptosis health disease pathogenesis. However, comprehensive up-to-date systematic review this domain remains absent. This aims to consolidate recent advancements understanding disease, focusing on underlying mechanisms potential therapeutic interventions. Dysregulation homeostasis, manifesting as either excess or deficiency, implicated etiology diseases. Cuproptosis, recently identified form cell death, characterized by intracellular overload. phenomenon mediates diverse array evolutionary processes organisms, spanning from genetic disorders, liver diseases, neurodegenerative cancers. provides summary pathogenic along with associated targeted agents. Furthermore, it explores future research directions yield treatment, management, prevention.

Language: Английский

Citations

7
Stem cell status and prognostic applications of cuproptosis-associated lncRNAs in acute myeloid leukemia DOI Creative Commons

Zhuodong Chai,

Zhongyue Yuan,

Yifei Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 14, 2025

Acute myeloid leukemia (AML), a highly heterogeneous hematological malignancy, remains major challenge in adult oncology. Stem cell research has highlighted the crucial role of long noncoding RNA (lncRNA) regulating cellular differentiation and self-renewal processes, which are pivotal AML pathogenesis therapy resistance. This study explores relationship between cuproptosis-related lncRNAs prognosis, providing novel insights into their impact on hematopoietic stem progenitor cells. We collected clinical information from 214 patients our center analyzed association granulocyte recovery after chemotherapy, cuproptosis, prognosis. Additionally, we developed prognostic model-the cuproptosis-associated model (CRLPM)-y analyzing data The Cancer Genome Atlas (TCGA). Patients were stratified high- low-risk groups based CRLPM, revealing significant survival differences. High-risk demonstrated lower sensitivity to chemotherapeutic agents such as Axitinib, GSK429286A, Navitoclax, ZM-447439, underscoring need for alternative therapeutic strategies. CRLPM offers promising framework integrating cell-focused approaches personalized treatment regimens, paving way precision medicine management.

Language: Английский

Citations

0
Impact of cuproptosis in gliomas pathogenesis with targeting options DOI

Mariam Markouli,

Panagiotis Skouras, Christina Piperi

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111394 - 111394

Published: Jan. 1, 2025

Language: Английский

Citations

0
Copper-based metal–organic frameworks for antitumor application DOI Creative Commons

Yangwei Qian,

Chenxi Wang, Risheng Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 22, 2025

It is urgent to exploit multifunctional materials and combined approaches for efficient antitumor effects. Copper-based metal–organic frameworks (Cu-MOFs) have excellent performances in catalysis, biocompatibility, photothermal conversion, regulate metabolism, which make them attract more attention application. Therefore, this review, representative ligands, synthetic methods, mechanism, applications of Cu-MOFs were provided. Special emphasis placed on the recent drug carriers, therapy, tumor imaging, theranostic, are summarized with examples. Finally, we presented dilemma faced by offered a new perspective future Hopefully, review may serve as reference further development application Cu-MOFs.

Language: Английский

Citations

0
Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy DOI
Suman Sekhar Sahoo, Debasish Manna

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Cancer remains one of the leading causes death individuals globally. Conventional treatment techniques like chemotherapy and radiation often suffer various drawbacks toxicity drug resistance. The study cell has been predominantly focused on classical forms apoptosis, but role metal ions in governing controlled is a fascinating less explored area. Metal‐mediated process where triggers via unique mechanism. Nanomaterial‐based strategies have gained attention for their ability to deliver precise therapeutic agents while also triggering Regulated Cell Death (RCD) mechanisms cancer cells. recently discovered metal‐mediated cuproptosis ferroptosis can be used as they selectively drug‐resistant cancer. Nano material‐based delivery system targeted sites. In this review, we given some idea about mechanism (ferroptosis cuproptosis) how initiate deaths using nanomaterials treatment.

Language: Английский

Citations

0
PER2 interaction with HSP70 promotes cuproptosis in oral squamous carcinoma cells by decreasing AKT stability DOI Creative Commons
Wenguang Yu,

Shilin Yin,

Hong Tang

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 20, 2025

Abstract Oral squamous cell carcinoma (OSCC) has a poor prognosis, with unclear mechanisms posing challenge for the development of effective treatment strategies. Cuproptosis is novel death mode that disrupts mitochondrial metabolism. Clarifying regulate cuproptosis may provide important new insights to guide OSCC treatment. Here, we found biological clock gene Period2 ( PER2 ) was under-expressed in OSCC, consequent inhibition cellular cuproptosis, whereas it overexpression vitro and vivo promoted cuproptosis. Mechanistically, bound heat shock protein 70 (HSP70) through its C-terminal domain, subsequently reducing interaction between HSP70 AKT leading enhanced degradation ubiquitination, promoting cells by inhibiting pathway upregulating DLAT, PDHB, SLC31A1 expression. Activating transcription factor 3 (ATF3) an upstream regulator , binds −807 −796 bp site promoter. Overexpression ATF3 dependent on transcriptional activation promotes cells. The anti-tumor effect inducer 1-targeted upregulation combined copper ionophore elesclomol (ES) be significantly compared monotherapy xenograft model. These findings reveal critical role ATF3-dependent regulation development, suggesting targeted or combination induce as strategy potentially improve prognosis patients.

Language: Английский

Citations

0