Artemisitene ameliorates carbon tetrachloride-induced liver fibrosis by inhibiting NLRP3 inflammasome activation and modulating immune responses DOI
Meng-Ke Liu, Juanjuan Tang, Hao Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113818 - 113818

Published: Dec. 15, 2024

Language: Английский

Artemisinins: Promising drug candidates for the treatment of autoimmune diseases DOI

Xu Gao,

Xian Lin, Qingwen Wang

et al.

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(2), P. 867 - 891

Published: Dec. 6, 2023

Abstract Autoimmune diseases are characterized by the immune system's attack on one's own tissues which highly diverse and differ in severity, causing damage virtually all human systems including connective tissue (e.g., rheumatoid arthritis), neurological system multiple sclerosis) digestive inflammatory bowel disease). Historically, treatments normally include pain‐killing medication, anti‐inflammatory drugs, corticosteroids, immunosuppressant drugs. However, given above characteristics, treatment of autoimmune has always been a challenge. Artemisinin is natural sesquiterpene lactone initially extracted separated from Chinese medicine Artemisia annua L., long history curing malaria. Artemisinin's derivatives such as artesunate, dihydroartemisinin, artemether, artemisitene, so forth, family artemisinins with antimalarial activity. Over past decades, accumulating evidence have indicated promising therapeutic potential diseases. Herein, we systematically summarized research regarding immunoregulatory properties artemisinin its derivatives, discussing their viability toward major underlying mechanisms. This review will provide new directions for basic clinical translational artemisinins.

Language: Английский

Citations

11
DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review DOI Creative Commons
Kajetan Kiełbowski,

Estera Bakinowska,

Anna Gorący

et al.

Epigenomes, Journal Year: 2025, Volume and Issue: 9(1), P. 2 - 2

Published: Jan. 8, 2025

Rheumatoid arthritis (RA) is a progressive autoimmune disease leading to structural and functional joint damage and, eventually, physical disability. The pathogenesis of the highly complex involves interactions between fibroblast-like synoviocytes (FLSs) immune cells, which stimulate secretion pro-inflammatory factors, chronic inflammation. In recent years, studies have demonstrated importance epigenetics in RA. Specifically, epigenetic alterations been suggested serve as diagnostic treatment biomarkers, while mechanisms are thought be involved Epigenetic regulators coordinate gene expression, case inflammatory diseases, they regulate expression broad range molecules. this review, we discuss current evidence on involvement DNA RNA methylation

Language: Английский

Citations

0
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids DOI
Dong Chen, Guangxin Li, Lianxiang Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156155 - 156155

Published: Oct. 18, 2024

Language: Английский

Citations

1
Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids DOI Open Access
Xian Lin,

Tengyu Lin,

Meng Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116871 - 116871

Published: June 10, 2024

Language: Английский

Citations

0
Molecular dynamics insight of interaction between Artemisinin and its derivatives and the cancer cell membrane DOI Creative Commons

Samaneh Boroomand,

Delara Mohammad-Aghaie,

Fatemeh Mohammadpour

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract In the present study, molecular dynamics simulation approach has been utilized to investigate effectiveness of four molecules, including Artemisinin, a natural product, and its derivatives Dihydroartemisinin, Artesunate, Artemisone, on cancer cell membrane model. Performed simulations predicted that Dihydroartemisinin Artemisone form stronger hydrogen bonds with membrane, exhibit higher mobility, have longer lifetime at water-membrane interface. molecules could penetrate hydrophobic part lipid’s tail which led fluidity membrane. These two compounds were able exert greatest effect change properties characteristics model while showing anti-cancer effects than other compounds. The outcomes predictions found agree results experimental studies. There is noticeable difference in way enter compared Artemisinin Artesunate. former from functional group side into latter pass it peroxide ring side.

Language: Английский

Citations

0
Molecular dynamics insight of interaction between Artemisinin and its derivatives and the cancer cell membrane DOI

Samaneh Boroomand,

Delara Mohammad-Aghaie,

Fatemeh Mohammadpour

et al.

Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 114997 - 114997

Published: Nov. 1, 2024

Language: Английский

Citations

0
Artemisitene ameliorates carbon tetrachloride-induced liver fibrosis by inhibiting NLRP3 inflammasome activation and modulating immune responses DOI
Meng-Ke Liu, Juanjuan Tang, Hao Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113818 - 113818

Published: Dec. 15, 2024

Language: Английский

Citations

0