Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1739, P. 465548 - 465548
Published: Nov. 23, 2024
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(39), P. 21548 - 21559
Published: Sept. 3, 2024
The simultaneous enhancement of lipophagy and mitochondrial biogenesis has emerged as a promising strategy for lipid lowering. transcription factor EB (TFEB) exhibits dual role, whereby it facilitates the degradation droplets (LDs) through process while simultaneously stimulating to support utilization products. purpose this study was explore effect astragaloside I (AS I) on hyperlipidemia elucidate its underlying mechanism. AS improved serum total cholesterol triglyceride levels reduced hepatic steatosis accumulation in db/db mice. enhanced fluorescence colocalization LDs autophagosomes promoted proteins genes related autolysosome. Moreover, increased expression biogenesis-related genes, indicating that biogenesis. Mechanistically, inhibits protein level p-TFEB (ser211) promotes TFEB nuclear translocation. activation by impeded upon introduction mammalian target rapamycin (mTOR) agonist MHY1485. inhibition p-mTOR were no longer observed after administration Akt SC-79, which indicated activated promote lipophagy-dependent Akt/mTOR pathway may be potentially effective pharmaceutical food additive treatment hyperlipidemia.
Language: Английский
Citations
3
Plant Signaling & Behavior, Journal Year: 2024, Volume and Issue: 19(1)
Published: May 22, 2024
During plant growth and development, the YABBY gene plays a crucial role in morphological structure, hormone signaling, stress resistance, crop breeding, agricultural production of lateral organs, leaves, flowers, fruits. Astragalus mongholicus is perennial herbaceous legume family, widely used worldwide due to its high medicinal edible value. However, there have been no reports family A. mongholicus. This study bioinformatics methods, combined with databases analysis websites, systematically analyze AmYABBY entire genome verified expression patterns different tissues through transcriptome data qRT-PCR experiments. A total seven genes were identified, which can be divided into five subfamilies distributed on three chromosomes. Two pairs may involved fragment duplication All proteins zinc finger domain, members same group similar motif composition intron – exon structure. In promoter region genes, light-responsive MeJa-response cis-elements are dominant. highly expressed stems especially AmYABBY1, AmYABBY2, AmYABBY3, play important roles development leaves. The regulates summary, this provides theoretical basis for in-depth research function new insights molecular response mechanism traditional Chinese medicine
Language: Английский
Citations
2
Cancer Management and Research, Journal Year: 2024, Volume and Issue: Volume 16, P. 909 - 919
Published: July 1, 2024
Abstract: The rising global morbidity and mortality rates of non-small cell lung cancer (NSCLC) underscore the urgent need for more effective treatments. Current therapeutic modalities—including surgery, radiotherapy, chemotherapy, targeted therapy—face several limitations. Recently, Astragalus membranaceus , a traditional Chinese medicine (TCM), has captured significant attention due to its broad pharmacological properties, such as immune regulation, anti-inflammatory effects, modulation reactive oxygen species (ROS) enzyme activities. This review delivers comprehensive summary most recent advancements ongoing applications in NSCLC treatment, underlining potential integration into existing treatment protocols. It also highlights essential areas future research, including elucidation molecular mechanisms, optimization dosage administration, evaluation efficacy safety alongside standard therapies, all which could potentially improve outcomes patients. Keywords: cancer, antitumor activity, immunoregulation, cisplatin
Language: Английский
Citations
2
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 9016 - 9032
Published: Aug. 17, 2024
Plants are the source of numerous remedies in modern medicine, and some them have been studied due to their potential immunomodulatory activity. Astragalus membranaceus Fisch. ex Bunge (A. membranaceus), Nigella sativa L. (N. sativa), Perilla frutescens (L.) Britton (P. frutescens) plant species used traditional medicine for treatment various diseases. Their act as immunomodulatory, anti-inflammatory, anti-allergic agents makes interesting investigating clinical alleviating symptoms allergic Allergy affects a large number people; according sources more than 30% world population suffer from type reaction, with pollen allergy most common type. Treatment is usually pharmacological may not be completely effective or side effects. Thus, we seeking mostly medicinal plants, promising symptoms. A literature overview was conducted employing databases such Scopus, PubMed, Web Science, Springer, Google Scholar. This manuscript summarizes recent vivo preclinical studies on three activity, provides comparison effects, underlines application practice. The obtained results confirmed efficacy studies, but also emphasize problem phytochemical characterization difference between tested doses. More trials standardized protocols (defined active molecules, dosage, effects) required obtain safe herbal drugs.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 12, 2024
Left ventricular remodeling (LVR) is a key factor leading to the onset and progression of heart failure with reduced ejection fraction (HFrEF). Improving LVR can delay HFrEF improve quality life.
Language: Английский
Citations
1
Encyclopedia, Journal Year: 2024, Volume and Issue: 4(1), P. 158 - 170
Published: Jan. 28, 2024
The aim of this systematic review is to study the effects Astragalus membranaceus (Huangqi) supplementation for sports activity and physical performance. PubMed, EMBASE, Web Science, Cochrane Library, Google Scholar were systematically searched relevant studies from inception up until October 2023. Eleven clinical considered eligible inclusion (six them involved administration Huangqi alone, while, in remaining trials, herb was supplemented combination with other remedies). On average, number participants ranged 8 120, activities practiced by subjects included martial arts, mountain hiking, basketball, rowing, running, aerobic exercises, strength training. When a dried extract used, taken at daily dose 1 4 g several weeks. associated improvements performance, oxidative status, reticulocytes percentage, response acclimatization, without specific effect on athletes’ strength. Better post-exercise immune functions also observed, especially regard NK cell activity, IL-2 levels, CD4+/CD8+ ratio, lymphocyte turnover. No adverse described. In conclusion, has potential decrease fatigue, enhance mitigate suppression athletes. It advisable conduct additional research subject robustness existing evidence through larger-scale controlled trials.
Language: Английский
Citations
1
Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 29, 2024
Introduction With the depletion of wild Astragali Radix (WA) resources, imitated-wild (IWA) and cultivated (CA) have become main products Radix. However, quality differences three growth patterns (WA, IWA, CA) different years not been fully characterized, leading to a lack necessary scientific evidence for their use as substitutes WA. Methods We innovatively proposed multidimensional evaluation method that encompassed traits, microstructure, cell wall components, saccharides, pharmacodynamic compounds, comprehensively explain variances among Results discussion Our study showed IWA WA was comparatively similar, including indicators such apparent color, sectional structure odor, thickness phellem, diameter number vessels, morphology phloem xylem, levels ratios cellulose, hemicellulose, lignin, sucrose, starch, water-soluble polysaccharides, total-saponins. content starch sorbose in CA significantly higher than WA, total-flavonoids were lower indicating significant between Hence, we suggest should be used substitute instead CA. As planting our results indicated aged 1-32 could divided into stages according change: rapid period (1-5 years), stable (6-20 elderly (25-32 years). Among these, 6-20 old exhibited consistent comparative results, showcasing elevated key active components flavonoids, saponins. Considering both cultivation expenses recommend duration 6-8 growers. In conclusion, established novel systematically characterize Radix, provided new perspective artificial assurance
Language: Английский
Citations
1
Journal of Herbal Medicine, Journal Year: 2024, Volume and Issue: 45, P. 100881 - 100881
Published: April 16, 2024
Language: Английский
Citations
1
Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Aug. 6, 2024
Objectives The aim of this meta-analysis is to evaluate the effect astragalus injection (AI) on left ventricular remodeling (LVR) in patients with heart failure mildly reduced ejection fraction (HFmrEF). Methods randomized controlled trials (RCTs) AI treating HFmrEF were retrieved from 8 major English and Chinese electronic databases, up until November 30, 2023. To methodological quality included studies, Cochrane bias risk tool Modified Jadad Scale employed. Stata 17.0 software was utilized for statistical analysis, sensitivity assessment publication bias. Results Ten RCTs 995 (562 males 433 females) identified. Meta-analysis indicated that compared conventional treatment (CT), significantly improved LVR, specifically increasing (LVEF, MD = 4.56, 95% CI: 3.68–5.44, p < 0.00001), decreasing end-diastolic volume (LVEDV, −7.89, −11.13 −4.64, diameter (LVEDD, −4.18, −5.79 −2.56, end-systolic (LVESV, −8.11, −11.79 −4.43, (LVESD, −3.42, −4.90 −1.93, 0.00001). also clinical efficacy (RR 4.62, 3.11–6.88, N-terminal pro-brain natriuretic peptide (NT-pro BNP, −27.94, −43.3 −12.36) level, without incidence adverse reactions 1.60, 0.59–4.29, 0.35). Sensitivity analysis confirmed reliability merged results, Begg's Egger's tests showed no significant Conclusion systematic review revealed combining CT improves LVR events patients. However, caution needed interpreting results due limited evidence. Future high-quality are support these conclusions. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , PROSPERO [CRD42022347248].
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 10 - 10
Published: Dec. 25, 2024
Background/Objectives: Astragalus L. is a genus of the Fabaceae family, encompassing over 3000 species globally, with 380 found in Turkey. This inaugural examination phytochemical, antioxidant, antibacterial, and cytotoxic properties pisidicus. Methods: The water methanolic fractions four parts (stems, flowers, leaves, root) as well whole plant were quantified identified by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) analysis. Cell death was assessed using WST-1 assay, while apoptosis colorimetric protease assay for caspase 2, -3, -6, -8, -9, cellular DNA fragmentation assay. Antioxidant activity A. pisidicus extracts investigated eight different assays. Antimicrobial activities evaluated against 16 bacterial strains disc diffusion broth microdilution methods. Results: A total 13 phytochemicals detected at various concentrations. Hesperidin (147-40,174 µg/g extract) hyperoside (363-2677 comprised principal constituents among extracts. Fm (IC50 = 9.57 µg/mL), Rm 14.89 Sm µg/mL) active crude on H1299, HT-29, Panc-1 cells, 32.057 64.25 moderately MCF-7 22RV1 respectively. elevation 3, 6, 8, 9 enzyme activities, along fragmentation, signifies that mode cell apoptosis. According to test results, Fm, Lm, Sm, WPm exhibited antimicrobial gram (+) bacteria. Conclusions: elicited apoptotic cancer cells selectively activation caspases subsequent may serve novel source an apoptosis-inducing anticancer drug.
Language: Английский
Citations
1