Construction of anticancer drug incorporated aptamer-functionalized cationic β-lactoglobulin: induction of cell cycle arrest and apoptosis in colorectal cancer DOI
Zhipeng Zhang, Tianran Zhang, Zimeng Li

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: Oct. 16, 2024

Nanoscale drug delivery systems that are both multifunctional and targeted have been developed using proteins as a basis, thanks to their attractive biomacromolecule properties. A novel nanocarrier, aptamer (AS1411)-conjugated β-lactoglobulin/poly-l-lysine (BLG/Ap/PL) nanoparticles, was in this study. To unique formulation, the as-prepared nanocarrier blends distinctive features of an chemotherapeutic targeting agent with those protein nanocarriers. By loading cabazitaxel (CTX) onto nanocarriers, therapeutic potential BLG/Ap/PL could be demonstrated. The CTX-loaded (CTX@BLG/Ap/PL) showed regulated release profile acidic milieu, which improve efficacy cancer cells high encapsulation up 93%. However, compared free CTX, CTX@BLG/Ap/PL killed colorectal HCT116 higher at 24 48 h. Further investigation confirms apoptosis by acridine orange ethidium bromide (AO/EB), DAPI staining morphological changes, chromatin condensation, membrane blebbing treated cell through flow cytometry displayed percentages apoptosis. Cell cycle analysis revealed induced sub-G1 G2/M phase (apoptosis) Annexin V/propidium iodide (PI) confirmed induces cells. Overall, study proved had several advantages over drugs promise solution clinical problems associated antitumor systems.

Language: Английский

Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy DOI Creative Commons

Zhongsong Zhang,

Rong Wang, Long Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 483 - 503

Published: Jan. 1, 2025

Abstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part immunotherapy. However, improve efficacy therapy is currently major challenge. Nanomaterials show their unique advantages whole process. At present, nanomaterials have achieved significant accomplishments medical applications, particularly field cancer-targeted therapy, showing enormous potential. It confirmed can not only directly target CAFs, but also interact with microenvironment (TME) immune affect tumorigenesis. As for treatment, could enhance therapeutic effect many ways. Therefore, this review, we first summarized current understanding complex interactions between TME, cells, cells. Next, discussed common modern medicine respective impacts on tumors. Finally, focus application nano drug delivery system therapy. Keywords: cancer-associated fibroblasts, delivery, nanomedicine, immunotherapy

Language: Английский

Citations

3
Neoadjuvant therapy for colorectal cancer from 2015 to 2024: a visual analysis and bibliometric analysis DOI Creative Commons

Boyu Kang,

Yihuan Qiao,

Junyong Zhu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 2, 2025

Colorectal cancer (CRC) imposes a substantial burden on global health., but research trends and hotspots in this field are still not clear. The purpose of is to create visual knowledge map based bibliometric analysis, identify predict future trends. Utilizing the Web Science Core Collection (WoSCC) as data source integrating visualization capabilities Bibliometrix R software package, CiteSpace, VOSviewer, analyze authors, institutions, countries, cited documents, publishing journals, abstracts, keyword information literature pertaining neoadjuvant therapy for colorectal spanning from January 2015 December 2024. analysis included 1,587 articles 1,464 385 61 countries or regions. China has largest number publications (449) citations (5,035). United States occupies leading position with an average 21.6. "Annals Surgical Oncology" most published journal 51 articles, "Journal Clinical references (4,465 references). Highly focus clinical trials guidelines cancer. In recent years, important keywords have been "artificial intelligence", "total therapy" "immunotherapy". This article provided review cancer, can provide reference subsequent results offered valuable insights that informed direction advancements.

Language: Английский

Citations

0
The Roles of Exosomes in Anti‐Cancer Drugs DOI Creative Commons

Panpan Feng,

Xiaodong Zhang, Jian Gao

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(9)

Published: April 29, 2025

Cancer is an escalating global health issue, with rising incidence rates annually. Chemotherapy, a primary cancer treatment, often exhibits low tumor-targeting efficiency and severe side effects, limiting its effectiveness. Recent research indicates that exosomes, due to their immunogenicity molecular delivery capabilities, hold significant potential as drug carriers for tumor treatment. This review summarizes the current status, powerful therapeutic potential, challenges of using exosomes treatment tumors. Exosomes are crucial in diagnosis, onset, progression. To improve efficacy exosome-based treatments, researchers exploring various biological, physical, chemical approaches engineer new nanomedicine translational therapy platform broad alterable capabilities. Numerous clinical trials currently underway investigating safety tolerability carrying drugs specific sites can be engineered deliver molecules cells tissues, offering novel approach disease

Language: Английский

Citations

0
Recent advances in nanocarrier systems for ulcerative colitis: A new era of targeted therapy and biomarker integration DOI
Sonia Chauhan, Ranjit K. Harwansh

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105466 - 105466

Published: Feb. 8, 2024

Language: Английский

Citations

3
Global research progress of nanomedicine and colorectal cancer: a bibliometrics and visualization analysis DOI Creative Commons
Siyu Tian, Min Chen

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 6, 2024

Surgery and chemoradiotherapy are the main clinical treatment methods for colorectal cancer (CRC), but prognosis is poor. The emergence of nanomedicine brings bright light to CRC. However, there has not been a comprehensive systematic analysis CRC by bibliometrics.

Language: Английский

Citations

1
Construction of anticancer drug incorporated aptamer-functionalized cationic β-lactoglobulin: induction of cell cycle arrest and apoptosis in colorectal cancer DOI
Zhipeng Zhang, Tianran Zhang, Zimeng Li

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: Oct. 16, 2024

Nanoscale drug delivery systems that are both multifunctional and targeted have been developed using proteins as a basis, thanks to their attractive biomacromolecule properties. A novel nanocarrier, aptamer (AS1411)-conjugated β-lactoglobulin/poly-l-lysine (BLG/Ap/PL) nanoparticles, was in this study. To unique formulation, the as-prepared nanocarrier blends distinctive features of an chemotherapeutic targeting agent with those protein nanocarriers. By loading cabazitaxel (CTX) onto nanocarriers, therapeutic potential BLG/Ap/PL could be demonstrated. The CTX-loaded (CTX@BLG/Ap/PL) showed regulated release profile acidic milieu, which improve efficacy cancer cells high encapsulation up 93%. However, compared free CTX, CTX@BLG/Ap/PL killed colorectal HCT116 higher at 24 48 h. Further investigation confirms apoptosis by acridine orange ethidium bromide (AO/EB), DAPI staining morphological changes, chromatin condensation, membrane blebbing treated cell through flow cytometry displayed percentages apoptosis. Cell cycle analysis revealed induced sub-G1 G2/M phase (apoptosis) Annexin V/propidium iodide (PI) confirmed induces cells. Overall, study proved had several advantages over drugs promise solution clinical problems associated antitumor systems.

Language: Английский

Citations

0