Cardioprotective Effects of Shaosha-7 on Acute Myocardial Infarction Through Sucrose Metabolism Regulation
Xiangjun Yang,
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Guohong Bao,
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Yuting Sun
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et al.
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(3)
Published: March 1, 2025
Objective:
This
study
aimed
to
identify
potential
target
proteins
of
the
Mongolian
drug
Shaosha-7
(SS-7)
for
amelioration
ischemia-reperfusion
injury
following
acute
myocardial
infarction
and
elucidate
its
comprehensive
mechanism
action
in
cardio-protection.
Methods:
The
toxicity
assay
was
conducted
using
zebrafish
H9c2
cardiomyocytes,
protective
effects
SS-7
against
I/R
were
studied
both
vitro
vivo.
A
TMT-based
quantitative
proteomics
analysis
performed
explore
global
on
rats.
therapeutic
traced
identified
immunohistochemistry
RT-PCR.
Result:
Our
results
suggested
that
exposure
induced
developmental
embryos
cardiomyocyte
toxicity.
could
effectively
improve
cardiac
function,
reverse
pathological
changes
rats
protect
cardiomyocytes.
In
addition,
omics
analyses
revealed
66
differentially
expressed
(DEPs)
associated
with
core
protein
targets
screened
through
protein-protein
interaction
(PPI)
analyses.
Gene
Ontology
(GO)
mainly
functioned
regulation
carbohydrate
biosynthetic
processes
generation
precursor
metabolites
energy.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
showed
DEPs
predominantly
starch
sucrose
metabolism
as
well
glycolysis/gluconeogenesis.
Immunohistochemistry,
ELISA,
RT-PCR
assays
further
support
findings
analysis.
We
highlighted
importance
glucose
treatment
demonstrated
can
be
used
a
novel
targeted
therapy
I/R.
Conclusion:
present
discovered
protects
from
by
influencing
metabolism.
experimental
may
provide
injury.
Language: Английский
Iridoid Glycosides in Kidney-Tonifying Chinese medicinal herbs: Mechanisms and Implications for Alzheimer’s Disease Therapy
Yanjie Qu,
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Min-Rui Ding,
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Mengxue Zhang
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et al.
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
348, P. 119870 - 119870
Published: April 25, 2025
Language: Английский
Lipid-lowering drugs and cancer: an updated perspective
Pharmacological Reports,
Journal Year:
2023,
Volume and Issue:
76(1), P. 1 - 24
Published: Nov. 28, 2023
Language: Английский
Exploring Butein’s anticancer potential in colorectal cancer: Insights into proliferation inhibition, apoptosis induction, and metastasis suppression via p38 signaling
Hongbo Wang,
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Jinshu Wang,
No information about this author
Yuhao Wang
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et al.
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
119, P. 106293 - 106293
Published: June 13, 2024
Language: Английский
A review of the sources and pharmacological research of morroniside
Pengliang Shi,
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Bingqing Zheng,
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Zhang Shiyao
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et al.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 4, 2024
Morroniside
(Mor)
is
a
bioactive
compound
found
in
Language: Английский
Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke
Yanxi Chen,
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Zhidong Xu,
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Yifu Ma
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et al.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 4, 2024
Until
now,
there
has
been
an
unmet
need
for
treatments
promoting
chronic-phase
post-stroke
functional
recovery.
We
previously
found
that
morroniside
promoted
endogenous
neurogenesis
in
ischemic
stroke,
but
its
therapeutic
window
was
limited
to
the
first
48
h.
Here,
we
aimed
explore
whether
deep
brain
stimulation
(DBS)
combined
with
could
enhance
rats
subjected
focal
stroke
and
contributes
Language: Английский