αO-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(1), P. 49 - 49

Published: Jan. 19, 2024

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful that occurs commonly during cancer management, which often leads to the discontinuation of medication. Previous studies suggest α9α10 nicotinic acetylcholine receptor (nAChR)-specific antagonist αO-conotoxin GeXIVA[1,2] effective in CIPN models; however, related mechanisms remain unclear. Here, we analyzed preventive effect on neuropathic pain long-term oxaliplatin injection-induced model. At end treatment, lumbar (L4-L6) spinal cord was extracted, and RNA sequencing bioinformatic analysis were performed investigate potential genes pathways GeXIVA[1,2]. inhibited development mechanical allodynia induced by chronic treatment. Repeated injections for 3 weeks had no mice’s normal threshold or locomotor activity anxiety-like behavior, as evaluated open field test (OFT) elevated plus maze (EPM). Our results identified 209 differentially expressed (DEGs) model, simultaneously injecting with altered 53 DEGs. These reverted significantly enriched immune-related represented cytokine–cytokine interaction pathway. findings could be therapeutic compound oxaliplatin-induced management.

Language: Английский

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Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1653 - 1653

Published: May 28, 2024

Palmitoylethanolamide (PEA) emerged over the years as a promising approach in management of chronic pain. Despite fact that efficacy micron-size PEA formulations appears to be time-dependent, optimal timing has not yet been elucidated. This systematic review and meta-analysis aim estimate possible advantage an extended treatment relief The literature search was conducted consulting scientific databases, identify clinical trials which administered for at least 60 days, pain assessed by Visual Analogue Scale (VAS) or Numeric Rating (NRS). Nine studies matched required criteria, total 742 patients involved. showed statistically clinically significant intensity reduction after days supplementation, compared 30 (1.36 points, p < 0.01). secondary analysis revealed weighted NRS/VAS score decrease 2.08 points within first month treatment. These two obtained scores corresponded 35.1% month, followed further 35.4% during second month. Overall, these results confirm relevant time-depended pain-relieving effect therefore treatment, especially patient with incomplete management.

Language: Английский

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New Insight into Neuropathic Pain: The Relationship between α7nAChR, Ferroptosis, and Neuroinflammation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6716 - 6716

Published: June 18, 2024

Neuropathic pain, which refers to pain caused by a lesion or disease of the somatosensory system, represents wide variety peripheral central disorders. Treating neuropathic is quite demanding, primarily because its intricate underlying etiological mechanisms. The nervous system relies on microglia maintain balance, as they are associated with serving primary immune responses in brain next cell communication. Ferroptosis, driven phospholipid peroxidation and regulated iron, vital mechanism death regulation. Neuroinflammation can be triggered ferroptosis microglia, contributes release inflammatory cytokines. Conversely, neuroinflammation induce iron accumulation resulting microglial ferroptosis. Accumulating evidence suggests that neuroinflammation, characterized glial activation substances, significantly exacerbates development pain. By inhibiting ferroptosis, it may possible prevent subsequently alleviate homopentameric α7 subtype neuronal nicotinic acetylcholine receptor (α7nAChR) has potential suppress activation, transitioning M1 an M2 phenotype, facilitating anti-inflammatory factors, ultimately reducing Recent years have witnessed growing recognition regulatory role α7nAChR could target for treating This review summarizes mechanisms related progress according recent research. Such exploration will help elucidate relationship between α7nAChR, provide new insights into management.

Language: Английский

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Effects of natural source polysaccharides on neurological diseases: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139697 - 139697

Published: Jan. 1, 2025

Language: Английский

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Trigeminal autonomic cephalalgia after common eye surgery: Case series and literature review

Revue Neurologique, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Opioid conversion in adults with cancer: MASCC-ASCO-AAHPM-HPNA-NICSO guideline

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 1, 2025

Language: Английский

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Environmental enrichment for neuropathic pain via modulation of neuroinflammation

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: March 21, 2025

Neuropathic pain causes tremendous biological and psychological suffering to patients worldwide. Environmental enrichment (EE) is a promising non-pharmacological strategy with high cost-effectiveness reduce neuropathic support rehabilitation therapy. Three researchers reviewed previous studies determine the efficacy of EE for research how improves through neuroinflammation. For this review, Embase, PubMed, Cochran were searched. authors did study selection data extraction. Out 74 papers, 7 met inclusion criteria. In chronic constriction injury rats acute or detrimental stimulation, change behavior was influenced by environmental settings like start time, cage size. Besides, physical has larger effect than socially in inflammatory pain. These articles suggest employing various regulate release pain-causing substances changes ion channels peripheral central nerves improve depression anxiety conditions. The existing proof provides important knowledge upcoming preclinical investigations practical use clinical treatment. This analysis aids advancement improved approaches managing pain, focus on internal mechanisms controlling

Language: Английский

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The experience of pain symptoms in patients with amyotrophic lateral sclerosis: a qualitative study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 25, 2025

ALS is a progressive neurodegenerative disease that has serious impact on patients and their caregivers. For long time in the past, was considered painless largely ignored by clinicians. Describing complexity needs of pain symptoms from perspective can provide most intuitive direction for future research. The purpose our research to explore experience with amyotrophic lateral sclerosis (ALS), reference better understanding patients. From April 2023 May 2023, 27 experiencing Peking University Third Hospital who met diagnostic criteria "Chinese Guidelines Diagnosis Treatment sclerosis" were interviewed means objective sampling. content analysis method used describe changes since (amyotrophic sclerosis), factors aggravate pain, measures cope needs. interview results included 3 themes 11 subthemes. (1) Pain diverse: type when occurs, change intensity, pain; (2) Individualized coping measures: posture adjustment, medication, physical therapy, warmth, emotional regulation; (3) Patients lack pain: insufficient source knowledge, single orientation solution. nature, location aggravating China are complicated, which should be paid attention clinical staff scientific researchers. situation management not optimistic, vast majority been effectively alleviated. It necessary realize importance self-management care others conduct further find breakthrough relief, so as strengthen intervention practice.

Language: Английский

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Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Repeated Administrations of Polyphenolic Extracts Prevent Chronic Reflexive and Non-Reflexive Neuropathic Pain Responses by Modulating Gliosis and CCL2-CCR2/CX3CL1-CX3CR1 Signaling in Spinal Cord-Injured Female Mice

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3325 - 3325

Published: April 2, 2025

Neuropathic pain after spinal cord injury lacks any effective treatments, often leading to chronic pain. This study tested whether the daily administration of fully characterized polyphenolic extracts from grape stalks and coffee could prevent both reflexive non-reflexive neuropathic in cord-injured mice by modulating neuroimmune axis. Female CD1 underwent mild contusion received intraperitoneal weeks one, three, six post-surgery. Reflexive responses were assessed weekly for up 10 weeks, was evaluated at study's end. Neuroimmune crosstalk investigated, focusing on glial activation expression CCL2/CCR2 CX3CL1/CX3CR1 supraspinal pain-related areas, including periaqueductal gray, rostral ventromedial medulla, anterior cingulate cortex, amygdala. Repeated treatments prevented mechanical allodynia thermal hyperalgesia, also modulated Moreover, they reduced gliosis regulated signaling. Overall, combination polyphenols these may offer a promising pharmacological strategy modifying central sensitization markers, not only site but key regions implicated data highlight potential injury-induced

Language: Английский

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